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公开(公告)号：US10968231B2
公开(公告)日：2021-04-06
申请号：US16497141
申请日：2018-03-29
发明人： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa , Satoshi Sasaki , Shigemitsu Matsumoto
IPC分类号： C07D491/052 , C07D211/22 , C07D401/12 , C07D401/14
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US10800754B2
公开(公告)日：2020-10-13
申请号：US16332993
申请日：2017-09-14
发明人： Takaharu Hirayama , Yasuhiro Hirata , Yusuke Tominari , Naoki Iwamura , Yusuke Sasaki , Moriteru Asano , Terufumi Takagi , Masanori Okaniwa , Masato Yoshida , Shinichi Imamura
IPC分类号： C07D401/04 , C07D401/14 , C07D407/14 , C07D409/14 , C07D417/14 , A61P35/00
摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US10519110B2
公开(公告)日：2019-12-31
申请号：US16175144
申请日：2018-10-30
发明人： Yasutomi Asano , Takuto Kojima , Osamu Kurasawa , Tzu-Tshin Wong , Yasuhiro Hirata , Naoki Iwamura , Bunnai Saito , Yuta Tanaka , Ryosuke Arai , Shinichi Imamura , Kazuko Yonemori , Yasufumi Miyamoto , Shuji Kitamura , Osamu Sano
IPC分类号： C07D211/58 , C07F9/6509 , C07D401/14 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , C07D215/42 , C07D401/06 , C07D401/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , A61P3/00 , A61P35/00 , C07B59/00 , C07D405/06 , C07D413/14
摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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公开(公告)号：US10774083B2
公开(公告)日：2020-09-15
申请号：US16333296
申请日：2017-09-14
发明人： Takaharu Hirayama , Yasuhiro Hirata , Yusuke Tominari , Naoki Iwamura , Yusuke Sasaki , Moriteru Asano , Terufumi Takagi , Masanori Okaniwa , Shinichi Imamura
IPC分类号： C07D401/04 , C07D401/14 , C07D473/28 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/40 , C07D519/00 , A61P35/00 , A61K31/506 , A61K31/444 , A61K31/4439 , C07D473/00 , C07D473/32 , A61K31/5377 , A61K31/501 , A61K31/52 , A61P43/00 , A61K31/437 , C12N9/99
摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein a group represented by is a group represented by the following formula (II) or the following formula (III): and other symbols are as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US09957251B2
公开(公告)日：2018-05-01
申请号：US15304623
申请日：2015-04-16
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D491/08 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4704 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/499 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/553 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , C07D213/64
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4704 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/499 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/553 , C07D213/64 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/107 , C07D498/08
摘要： The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.
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公开(公告)号：US20150018422A1
公开(公告)日：2015-01-15
申请号：US14377953
申请日：2013-02-12
发明人： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata , Akito Shibuya
IPC分类号： C07C59/135
CPC分类号： C07C59/135 , C07C59/68 , C07C59/70 , C07C59/72 , C07C229/34 , C07C233/47 , C07C235/34 , C07C255/37 , C07C255/41 , C07C255/46 , C07C309/65 , C07C309/66 , C07C311/21 , C07C317/44 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D231/12 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/24 , C07D285/12 , C07D309/06 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14
摘要： Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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公开(公告)号：US11186565B2
公开(公告)日：2021-11-30
申请号：US16499432
申请日：2018-03-29
发明人： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Kazuaki Takami , Norihito Tokunaga , Tomohiro Okawa , Akito Shibuya , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa
IPC分类号： C07D401/12 , C07C59/72 , C07D211/22 , C07D213/64 , C07D401/10 , C07D401/14 , C07D413/10
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US09776962B2
公开(公告)日：2017-10-03
申请号：US14898633
申请日：2014-08-08
发明人： Jumpei Aida , Yayoi Yoshitomi , Yuko Hitomi , Naoyoshi Noguchi , Yasuhiro Hirata , Hideki Furukawa , Akito Shibuya , Koji Watanabe , Yasufumi Miyamoto , Tomohiro Okawa , Nobuyuki Takakura , Seiji Miwatashi
IPC分类号： C07D211/34 , C07D211/22 , C07D213/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
CPC分类号： C07D211/34 , C07D211/22 , C07D213/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
摘要： Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
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公开(公告)号：US09181186B2
公开(公告)日：2015-11-10
申请号：US14377951
申请日：2013-02-12
发明人： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata
IPC分类号： C07D213/64 , C07D405/14 , C07D401/12 , C07D239/34 , C07D213/30 , C07D213/68 , C07D213/69 , C07D213/55 , C07D403/12
CPC分类号： C07D213/64 , C07D213/30 , C07D213/55 , C07D213/68 , C07D213/69 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/14
摘要： Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译： 提供具有GPR40激动剂活性的芳环化合物。 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性，并且可用作预防或治疗糖尿病等的药剂。
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公开(公告)号：US11584737B2
公开(公告)日：2023-02-21
申请号：US17042394
申请日：2019-03-28
发明人： Koji Ono , Masahiro Ito , Toshio Tanaka , Moriteru Asano , Takaharu Hirayama , Jun Fujimoto , Nobuki Sakauchi , Yasuhiro Hirata , Akinori Toita , Nao Morishita , Hironori Kokubo , Yasuhiro Imaeda , Hironobu Maezaki , Douglas Robert Cary , Ryo Mizojiri , Nobuo Cho , Hiroshi Banno , Hidekazu Tokuhara , Yasuyoshi Arikawa
IPC分类号： C07D401/14 , C07D403/14 , A61P35/00 , C07D213/84 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/10 , C07D487/10 , C07D495/10
摘要： Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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