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公开(公告)号：US10729661B2
公开(公告)日：2020-08-04
申请号：US15532840
申请日：2015-12-17
发明人： Kazushi Itou , Takayuki Akamine , Saori Tone , Daichi Kawamura , Yoshiko Abe
摘要： A particle comprising a first fraction containing an active ingredient and a second fraction containing a surfactant, and having a number average particle diameter of from 1 to 100 nm.
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2.发明申请公开(公告)号：US20200368356A1
公开(公告)日：2020-11-26
申请号：US16990634
申请日：2020-08-11
发明人： Daichi Kawamura , Takayuki Akamine , Saori Tone , Yuuta Nakamura , Izumi Matsumoto , Kazushi Itou
IPC分类号： A61K47/14 , A61K47/18 , A61K8/37 , A61K8/42 , A61K9/70 , A61Q19/00 , A61K9/06 , A61K9/00 , A61K9/10 , A61K47/26
摘要： Provided is a core-shell structure having an excellent immediate effect in transdermal absorption of an active ingredient.A core-shell structure comprising a core portion containing an active ingredient, and a shell portion containing a surfactant having an HLB value of 4 to 14, the core portion being solid, and the surfactant containing a saturated hydrocarbon group having 7 to 15 carbon atoms or an unsaturated hydrocarbon group having 7 to 17 carbon atoms.
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公开(公告)号：US20190328671A1
公开(公告)日：2019-10-31
申请号：US16508273
申请日：2019-07-10
发明人： Saori Tone , Izumi Matsumoto , Takayuki Akamine , Daichi Kawamura , Kazushi Itou , Yoshiko Abe
IPC分类号： A61K9/19 , A61K9/70 , A61K47/26 , A61K9/00 , A61K8/02 , A61K47/32 , A61Q19/00 , A61K8/73 , A61K31/13 , A61K47/36 , A61K8/81
摘要： Provided are an active ingredient-containing particle with improved shape retainability. The particle includes a first fraction containing an active ingredient, a second fraction containing a surfactant, and at least one water-soluble polymer selected from the group consisting of a polysaccharide and a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constituent unit.
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公开(公告)号：US10561603B2
公开(公告)日：2020-02-18
申请号：US15740335
申请日：2016-06-29
发明人： Takayuki Akamine , Kazushi Itou , Saori Tone , Yoshiko Abe
IPC分类号： A61K9/00 , A61K31/445 , A61K31/53 , A61K9/10 , A61K38/00 , A61K9/06 , A61K9/50 , A61K47/44 , A61K47/14
摘要： The present invention provides a core-shell structure having high skin permeability. The core-shell structure includes a core portion containing a hydrophilic drug having a molecular weight of 400 or more; and a shell portion containing a surfactant, and the core portion is a solid, the hydrophilic drug has a water-octanol partition coefficient of −3 or more and 6 or less, the surfactant has an alkyl group or an alkenyl group having 10 to 20 carbon atoms, and a mass ratio between the hydrophilic drug and the surfactant (hydrophilic drug:surfactant) is 1:5 to 1:20.
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公开(公告)号：US20170354614A1
公开(公告)日：2017-12-14
申请号：US15532840
申请日：2015-12-17
发明人： Kazushi Itou , Takayuki Akamine , Saori Tone , Daichi Kawamura , Yoshiko Abe
IPC分类号： A61K9/51
摘要： A particle comprising a first fraction containing an active ingredient and a second fraction containing a surfactant, and having a number average particle diameter of from 1 to 100 nm.
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公开(公告)号：US20200281862A1
公开(公告)日：2020-09-10
申请号：US16756097
申请日：2018-11-20
发明人： Saori Tone , Takayuki Akamine , Daichi Kawamura , Yuuta Nakamura
IPC分类号： A61K9/50 , A61K9/00 , A61K47/40 , A61K31/496 , A61K31/4402 , A61K47/12
摘要： Provided is an external skin preparation capable of enhancing permeability of an active ingredient into parts of the epidermis located below the stratum corneum and the dermis even when a poorly water-soluble active ingredient is used. There is provided an external skin preparation comprising a poorly water-soluble active ingredient and a solubilizing agent, wherein the solubilizing agent is at least one selected from the group consisting of water-soluble polymers, water-soluble saccharides, water-soluble surfactants and aromatic carboxylic acids.
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7.发明申请公开(公告)号：US20190117777A1
公开(公告)日：2019-04-25
申请号：US16089309
申请日：2018-02-07
发明人： Daichi Kawamura , Takayuki Akamine , Saori Tone , Yuuta Nakamura , Izumi Matsumoto , Kazushi Itou
摘要： Provided is a core-shell structure having an excellent immediate effect in transdermal absorption of an active ingredient.A core-shell structure comprising a core portion containing an active ingredient, and a shell portion containing a surfactant having an HLB value of 4 to 14, the core portion being solid, and the surfactant containing a saturated hydrocarbon group having 7 to 15 carbon atoms or an unsaturated hydrocarbon group having 7 to 17 carbon atoms.
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公开(公告)号：US20180318220A1
公开(公告)日：2018-11-08
申请号：US15773982
申请日：2016-12-22
发明人： Saori Tone , Izumi Matsumoto , Takayuki Akamine , Daichi Kawamura , Kazushi Itou , Yoshiko Abe
摘要： Provided are an active ingredient-containing particle with improved shape retainability. The particle includes a first fraction containing an active ingredient, a second fraction containing a surfactant, and at least one water-soluble polymer selected from the group consisting of a polysaccharide and a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constituent unit.
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公开(公告)号：US20180185273A1
公开(公告)日：2018-07-05
申请号：US15740335
申请日：2016-06-29
发明人： Takayuki Akamine , Kazushi Itou , Saori Tone , Yoshiko Abe
IPC分类号： A61K9/00 , A61K47/14 , A61K31/445 , A61K31/53
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/5015 , A61K31/445 , A61K31/53 , A61K38/00 , A61K47/14 , A61K47/44
摘要： The present invention provides a core-shell structure having high skin permeability. The core-shell structure includes a core portion containing a hydrophilic drug having a molecular weight of 400 or more; and a shell portion containing a surfactant, and the core portion is a solid, the hydrophilic drug has a water-octanol partition coefficient of −3 or more and 6 or less, the surfactant has an alkyl group or an alkenyl group having 10 to 20 carbon atoms, and a mass ratio between the hydrophilic drug and the surfactant (hydrophilic drug:surfactant) is 1:5 to 1:20.
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公开(公告)号：US11033506B2
公开(公告)日：2021-06-15
申请号：US16756097
申请日：2018-11-20
发明人： Saori Tone , Takayuki Akamine , Daichi Kawamura , Yuuta Nakamura
IPC分类号： A61K9/50 , A61K9/00 , A61K31/4402 , A61K31/496 , A61K47/12 , A61K47/40
摘要： Provided is an external skin preparation capable of enhancing permeability of an active ingredient into parts of the epidermis located below the stratum corneum and the dermis even when a poorly water-soluble active ingredient is used. There is provided an external skin preparation containing a core-shell structure, comprising a core portion containing a poorly water-soluble active ingredient and a solubilizing agent, and a shell portion containing a surfactant. The solubilizing agent is at least one selected from the group consisting of cyclodextrin, methyl-cyclodextrin, dimethyl-cyclodextrin, 2-hydroxypropyl-cyclodextrin, hydroxyethyl-cyclodextrin, sulfobutyl ether-cyclodextrin, glucosyl-cyclodextrin, maltosyl-cyclodextrin and cluster dextrin. The surfactant is at least one selected from the group consisting of glycerol fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters and fatty acid alkanolamides. A mass ratio between the poorly water-soluble active ingredient and the solubilizing agent (poorly water-soluble active ingredient:solubilizing agent) is 1:0.1 to 1:30.
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