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公开(公告)号：US20190328671A1
公开(公告)日：2019-10-31
申请号：US16508273
申请日：2019-07-10
发明人： Saori Tone , Izumi Matsumoto , Takayuki Akamine , Daichi Kawamura , Kazushi Itou , Yoshiko Abe
IPC分类号： A61K9/19 , A61K9/70 , A61K47/26 , A61K9/00 , A61K8/02 , A61K47/32 , A61Q19/00 , A61K8/73 , A61K31/13 , A61K47/36 , A61K8/81
摘要： Provided are an active ingredient-containing particle with improved shape retainability. The particle includes a first fraction containing an active ingredient, a second fraction containing a surfactant, and at least one water-soluble polymer selected from the group consisting of a polysaccharide and a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constituent unit.
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公开(公告)号：US20180318220A1
公开(公告)日：2018-11-08
申请号：US15773982
申请日：2016-12-22
发明人： Saori Tone , Izumi Matsumoto , Takayuki Akamine , Daichi Kawamura , Kazushi Itou , Yoshiko Abe
摘要： Provided are an active ingredient-containing particle with improved shape retainability. The particle includes a first fraction containing an active ingredient, a second fraction containing a surfactant, and at least one water-soluble polymer selected from the group consisting of a polysaccharide and a polymer having 2-methacryloyloxyethyl phosphorylcholine as a constituent unit.
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公开(公告)号：US20180185273A1
公开(公告)日：2018-07-05
申请号：US15740335
申请日：2016-06-29
发明人： Takayuki Akamine , Kazushi Itou , Saori Tone , Yoshiko Abe
IPC分类号： A61K9/00 , A61K47/14 , A61K31/445 , A61K31/53
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/10 , A61K9/5015 , A61K31/445 , A61K31/53 , A61K38/00 , A61K47/14 , A61K47/44
摘要： The present invention provides a core-shell structure having high skin permeability. The core-shell structure includes a core portion containing a hydrophilic drug having a molecular weight of 400 or more; and a shell portion containing a surfactant, and the core portion is a solid, the hydrophilic drug has a water-octanol partition coefficient of −3 or more and 6 or less, the surfactant has an alkyl group or an alkenyl group having 10 to 20 carbon atoms, and a mass ratio between the hydrophilic drug and the surfactant (hydrophilic drug:surfactant) is 1:5 to 1:20.
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公开(公告)号：US10561603B2
公开(公告)日：2020-02-18
申请号：US15740335
申请日：2016-06-29
发明人： Takayuki Akamine , Kazushi Itou , Saori Tone , Yoshiko Abe
IPC分类号： A61K9/00 , A61K31/445 , A61K31/53 , A61K9/10 , A61K38/00 , A61K9/06 , A61K9/50 , A61K47/44 , A61K47/14
摘要： The present invention provides a core-shell structure having high skin permeability. The core-shell structure includes a core portion containing a hydrophilic drug having a molecular weight of 400 or more; and a shell portion containing a surfactant, and the core portion is a solid, the hydrophilic drug has a water-octanol partition coefficient of −3 or more and 6 or less, the surfactant has an alkyl group or an alkenyl group having 10 to 20 carbon atoms, and a mass ratio between the hydrophilic drug and the surfactant (hydrophilic drug:surfactant) is 1:5 to 1:20.
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公开(公告)号：US20170354614A1
公开(公告)日：2017-12-14
申请号：US15532840
申请日：2015-12-17
发明人： Kazushi Itou , Takayuki Akamine , Saori Tone , Daichi Kawamura , Yoshiko Abe
IPC分类号： A61K9/51
摘要： A particle comprising a first fraction containing an active ingredient and a second fraction containing a surfactant, and having a number average particle diameter of from 1 to 100 nm.
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公开(公告)号：US10729661B2
公开(公告)日：2020-08-04
申请号：US15532840
申请日：2015-12-17
发明人： Kazushi Itou , Takayuki Akamine , Saori Tone , Daichi Kawamura , Yoshiko Abe
摘要： A particle comprising a first fraction containing an active ingredient and a second fraction containing a surfactant, and having a number average particle diameter of from 1 to 100 nm.
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公开(公告)号：US20190388350A1
公开(公告)日：2019-12-26
申请号：US16016507
申请日：2018-06-22
发明人： Saori Tone , Kazushi Itou , Takayuki Akamine , Daichi Kawamura , Yoshiko Abe
IPC分类号： A61K9/16 , A61K31/445 , A61K31/53 , A61K31/27 , A61K31/381
摘要： Problem to be SolvedThere is provided a formulation including a particle containing an active ingredient and a surfactant, wherein morphological stability is excellent.SolutionA particle containing an active ingredient, a surfactant and a pH adjuster.
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公开(公告)号：US10130710B2
公开(公告)日：2018-11-20
申请号：US15502754
申请日：2015-09-18
发明人： Takayuki Akamine , Kazushi Itou , Saori Tone , Yoshiko Abe
IPC分类号： A61K47/26 , A61K47/06 , A61K47/14 , A61K9/10 , A61K31/13 , A61K9/00 , A61K45/06 , A61K9/14 , A61K9/16 , A61K9/50 , A61K31/445 , A61K31/47 , A61K31/53
摘要： An object is to provide a formulation that includes a particle containing an active ingredient and a surfactant, and a base, and is more excellent in storage stability. For solution, a formulation including a particle containing an active ingredient and a surfactant, and a base, in which the surfactant is contained in a ratio of 5 to 100 parts by weight based on 1 part by weight of the active ingredient, is provided.
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公开(公告)号：US20180311357A1
公开(公告)日：2018-11-01
申请号：US15770071
申请日：2016-12-28
发明人： Takayuki Akamine , Izumi Matsumoto , Saori Tone , Daichi Kawamura , Kazushi Itou , Yoshiko Abe
摘要： An object of the present invention is to prevent a particle including a first fraction containing an active ingredient and a second fraction containing a surfactant from bleeding out from the base phase of an external preparation. The external preparation comprises a particle including a first fraction containing an active ingredient and a second fraction containing a surfactant, and a base phase containing a gelatinous liquid component.
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公开(公告)号：US20170232106A1
公开(公告)日：2017-08-17
申请号：US15502754
申请日：2015-09-18
发明人： Takayuki Akamine , Kazushi Itou , Saori Tone , Yoshiko Abe
CPC分类号： A61K47/26 , A61K9/0014 , A61K9/10 , A61K9/145 , A61K9/1617 , A61K9/1623 , A61K9/5015 , A61K31/13 , A61K31/445 , A61K31/47 , A61K31/53 , A61K45/06 , A61K47/06 , A61K47/14
摘要： An object is to provide a formulation that includes a particle containing an active ingredient and a surfactant, and a base, and is more excellent in storage stability. For solution, a formulation including a particle containing an active ingredient and a surfactant, and a base, in which the surfactant is contained in a ratio of 5 to 100 parts by weight based on 1 part by weight of the active ingredient, is provided.
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