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公开(公告)号：US20220313796A1
公开(公告)日：2022-10-06
申请号：US17742104
申请日：2022-05-11
发明人： Sungyong IN , Sunghwa CHOE , Mi Jin PARK , Aiden Y. PARK , Jung Hak LIM , Dong Wook KIM , Youngdong YOO , Jongjin PARK
IPC分类号： A61K38/46 , A61P35/00 , A61K31/7052 , C12N9/22 , C12N9/52 , C12N15/113
摘要： Enhanced, specific nucleic acid targeting complexes comprising endo and exonuclease activity, and related methods that allow both targeted degradation of specific and/or non-specific nucleic acids in vivo and specific temporal regulation of nuclease activity to prevent off-target activity are disclosed herein. Through practice of the disclosure, nucleic acids, and cells harboring them, such as cancer cells or pathogens, are selectively degraded in vivo.
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公开(公告)号：US20210340554A1
公开(公告)日：2021-11-04
申请号：US17366320
申请日：2021-07-02
发明人： Jin Soo KIM , Jungeun KIM , Sunghwa CHOE , Je Wook WOO , Soon Il KWON , Hyeran KIM
摘要： The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA ribonucleoprotein (RNP). According to the present invention, the method of increasing the production efficiency of gene-edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.
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公开(公告)号：US20210077594A1
公开(公告)日：2021-03-18
申请号：US17033313
申请日：2020-09-25
发明人： Sungyong IN , Sunghwa CHOE , Mi Jin PARK , Aiden Y. PARK , Jung Hak LIM , Dong Wook KIM , Youngdong YOO , Jongjin PARK
IPC分类号： A61K38/46 , A61K31/7052 , A61P35/00
摘要： Enhanced, specific nucleic acid targeting complexes comprising endo and exonuclease activity, and related methods that allow both targeted degradation of specific and/or non-specific nucleic acids in vivo and specific temporal regulation of nuclease activity to prevent off-target activity are disclosed herein. Through practice of the disclosure, nucleic acids, and cells harboring them, such as cancer cells or pathogens, are selectively degraded in vivo.
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公开(公告)号：US20220389404A1
公开(公告)日：2022-12-08
申请号：US17684298
申请日：2022-03-01
发明人： Jongjin PARK , Ji Young YOON , Sunmee CHOI , Mijin PARK , Slki PARK , Aiden Y. PARK , Jung Hyuk LEE , Junghak LIM , Dong Wook KIM , Sunghwa CHOE
IPC分类号： C12N15/10 , C12N9/22 , C12N15/113
摘要： The present disclosure provides compositions and methods for increasing mutation efficiency and homologous recombination rates of site-specific endonucleases. The compositions and methods comprise a chimeric polypeptide comprising a site-specific endonuclease or a domain thereof and a functional moiety. The current inventions relate to functional enhancement of the CRISPR-Cas enzymes. Disclosed herein include possible variants and their intended improvements.
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公开(公告)号：US20210222140A1
公开(公告)日：2021-07-22
申请号：US17171302
申请日：2021-02-09
发明人： Sunghwa CHOE , Jongjin PARK , Jiyoung YOON , Han Seong KIM , Dong Wook KIM
摘要： The present disclosure provides novel Cas12a proteins, which cleave target nucleic acids and methods of use thereof.
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公开(公告)号：US20180312869A1
公开(公告)日：2018-11-01
申请号：US15766432
申请日：2016-10-06
发明人： Jin Soo KIM , Jungeun KIM , Sunghwa CHOE , Je Wook WOO , Soon II KWON
IPC分类号： C12N15/82
CPC分类号： A01H5/12 , C12N15/8213 , C12N15/8298
摘要： The present invention relates to method for preparing a plant from a protoplast comprising knocking-out or knocking-in one or more the endogenous gene of the protoplast, and the plant regenerated from a genome-modified protoplast prepared by the above method.
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公开(公告)号：US20190338298A1
公开(公告)日：2019-11-07
申请号：US15766445
申请日：2016-10-06
发明人： Jin Soo KIM , Jungeun KIM , Sunghwa CHOE , Je Wook WOO , Soon II KWON , Hyeran KIM
摘要： The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA ribonucleoprotein (RNP). According to the present invention, the method of increasing the production efficiency of gene-edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.
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公开(公告)号：US20170291927A1
公开(公告)日：2017-10-12
申请号：US15470269
申请日：2017-03-27
发明人： Sunghwa CHOE , Yu Jeong JEONG
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C07K14/415 , C12N15/8261 , C12N15/8298
摘要： The present invention relates to a gene that regulates BIN2 function and a transgenic plant into which the gene is introduced. When the gene of the present invention is introduced into an economically useful crop, it is advantageous to produce a high value-added plant with excellent productivity.
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公开(公告)号：US20210292722A1
公开(公告)日：2021-09-23
申请号：US17266882
申请日：2019-08-09
发明人： Sunghwa CHOE , Han Seong KIM , Dong Wook KIM , Jongjin PARK , Jiyoung YOON
IPC分类号： C12N9/22 , A61K38/46 , C12N15/11 , A61K31/7088
摘要： A novel CRISPR-associated protein and a use thereof are disclosed. A protein of the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 3 exhibits the activity of endonucleases, which recognize and cleave an intracellular nucleic acid sequence linked to a guide RNA. Therefore, a novel CRISPR-associated protein can be used as a different nuclease for genome editing, in a CRISPR-Cas system.
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公开(公告)号：US20190119750A1
公开(公告)日：2019-04-25
申请号：US16174522
申请日：2018-10-30
发明人： Sunghwa CHOE , Maya Maharjan PUNA , Slki PARK , Richard CHA
IPC分类号： C12Q1/6876 , G01N33/96 , A01H5/00 , C12Q1/6897
摘要： The present disclosure relates to a method for discovering effective bioactive compounds, based on plant developmental biology, and aims to discover a lead bioactive compound for new drugs by repeating screening based on phenotypes of a plant as a marker on the basis of plant developmental biology. To this end, the present disclosure provides a method for discovering effective bioactive compounds, and includes screening candidates for developing a new drug by using unique phenotypes as a marker shown by a plant when it is grown with a specific material.
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