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1.发明申请公开(公告)号：US20190382446A1
公开(公告)日：2019-12-19
申请号：US16464099
申请日：2017-12-27
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION. CO. LTD
摘要： The present invention relates to a novel peptide derived from the copine 7 protein and having both cell permeability and bone tissue regeneration ability, and to a use of the peptide. The peptide according to the present invention has excellent bone tissue regeneration ability and is therefore useful for treating a disease requiring bone regeneration, such as osteoporosis. Particularly, by also having cell permeability, the peptide does not require the attachment of a separate peptide or addition of another preparation for the cell permeation thereof and thus can be conveniently applied in orthopedics and the like requiring various surgical regeneration treatments.
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公开(公告)号：US20200283481A1
公开(公告)日：2020-09-10
申请号：US16882648
申请日：2020-05-25
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
摘要： Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.
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公开(公告)号：US20210147482A1
公开(公告)日：2021-05-20
申请号：US16625692
申请日：2018-06-19
发明人： Seung Hyun HAN , Ok-Jin PARK , Jiseon KIM , Ki Bum AHN , Yoon Jeong PARK , Chong-Pyoung CHUNG , Jue-Yeon LEE
摘要： The present invention relates to a peptide for inhibiting bone resorption and, more specifically, to a peptide for inhibiting bone destruction by inhibiting the differentiation and activity of osteoclasts. According to the present invention, a peptide for inhibiting bone resorption can inhibit bone destruction by inhibiting the differentiation and activity of osteoclasts, and thus can be used as a therapeutic agent for various bone diseases caused by an excessive increase in the activity of osteoclasts.
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4.发明公开公开(公告)号：US20240287206A1
公开(公告)日：2024-08-29
申请号：US18568180
申请日：2022-06-10
CPC分类号： C07K16/40 , C07K14/47 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/01 , C07K2319/95
摘要： The present invention relates to a proteolysis targeting chimera (PROTAC) protein having an intracellular delivery function, and a pharmaceutical composition comprising same. The PROTAC protein according to the present invention has higher solubility than a PROTAC prepared by a conventional method and efficiently degrades intrinsic disease proteins when applied to cells, and thus is effective in the treatment of cancer or inflammatory diseases.
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公开(公告)号：US20210138111A1
公开(公告)日：2021-05-13
申请号：US16623167
申请日：2017-07-27
摘要： The present invention relates to an integrated biomaterial for bone tissue regeneration and a method of preparing the same, and more particularly to an integrated biomaterial for bone tissue regeneration, which includes a lower structure consisting of an extracellular matrix protein and a bone mineral and an upper layer consisting of an extracellular matrix protein. In the integrated biomaterial for bone tissue regeneration according to the present invention, the lower structure consisting of an extracellular matrix protein and a bone mineral component realizes a natural bone tissue environment, and thus facilitates the regeneration of new bone, and particularly, the upper layer consisting of an extracellular matrix protein is placed thereon at an appropriate ratio, and thus not only prevents the infiltration of epithelial tissue or connective tissue but also maximizes bone tissue regeneration capability.
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公开(公告)号：US20240269302A1
公开(公告)日：2024-08-15
申请号：US18567167
申请日：2022-06-10
IPC分类号： A61K47/64 , A61K47/54 , A61K48/00 , A61P35/00 , C12N15/113
CPC分类号： A61K47/6455 , A61K47/543 , A61K48/0033 , A61P35/00 , C12N15/1137 , C12N2310/14
摘要： The present invention relates to a carrier for delivering oligonucleotides into cells for therapeutic use. To inhibit a target protein or promote expression of a target protein in a cell, a peptide-lipid conjugate is prepared, and a nanoparticle consisting of a peptide-lipid conjugate comprising oligonucleotides and a pharmaceutical composition comprising same are provided. It was confirmed that, by using the nanoparticle consisting of a peptide-lipid conjugate according to the present invention, oligonucleotides were effectively delivered into cells. In addition, by confirming that expression of a cancer-causing protein is reduced by the oligonucleotides and an anticancer effect is exhibited in an animal model in which cancer occurs, the nanoparticle consisting of a peptide-lipid conjugate was found to be effective in the delivery of oligonucleotides.
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公开(公告)号：US20240238368A1
公开(公告)日：2024-07-18
申请号：US18262543
申请日：2022-01-24
摘要： The present invention relates to a peptide for preventing or treating fibrosis, having the effects of preventing or treating fibrosis by having the property of inhibiting the dissociation of TGF-β1 from LCC by binding to an integrin or the property of inhibiting the change from epithelial cells to mesenchymal cells and promoting the change from mesenchymal cells to epithelial cells, and the property of penetrating cells to bind to Smad2 and Smad3, and thus suppresses the phosphorylation thereof. A peptide according to the present invention exhibits better therapeutic effects than Nintedanib, which was commercialized as a therapeutic agent for pulmonary fibrosis, and Liraglutide, which was commercialized as a therapeutic agent for hepatic fibrosis, and thus can be used as an alternative therapeutic agent to these commercially available therapeutic agents or as an agent for combination therapy with these therapeutic agents.
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公开(公告)号：US20200113801A1
公开(公告)日：2020-04-16
申请号：US16498951
申请日：2018-03-19
发明人： Seung Hyun HAN , Kee-Yeon KUM , Ki Bum AHN , Ok-Jin PARK , Chong-Pyoung CHUNG , Yoon Jeong PARK , Jue-Yeon LEE
摘要： The present invention relates to: a composition for inhibiting biofilms, containing, as an active ingredient, a peptide derived from human β-defensin-3; and a method for inhibiting biofilms by using the composition. The peptide according to the present invention inhibits bacterial biofilms even when used alone and exhibits a remarkably increased biofilm inhibitory effect when used in combination with a conventional dental therapeutic agent, and has an effect of preventing a tooth discoloration side effect caused by a conventional dental therapeutic agent.
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