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公开(公告)号：US20170202972A1
公开(公告)日：2017-07-20
申请号：US15480122
申请日：2017-04-05
发明人： Randall MOREADITH , Kunsang Yoon , Zhihao Fang , Rebecca Weimer , Bekir Dizman , Tacey Viegas , Michael David Bentley
IPC分类号： A61K47/48 , A61K31/4462 , A61K31/4535 , A61K9/00 , A61K31/7048 , A61K31/4745 , A61K31/381 , A61K31/4045 , A61K47/34
摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
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公开(公告)号：US20130177521A1
公开(公告)日：2013-07-11
申请号：US13774304
申请日：2013-02-22
发明人： Randall Moreadith , Michael David Bentley , Kunsang Yoon , Zhihao Fang , Rebecca Weimer , Bekir Dizman , Tacey Viegas
IPC分类号： A61K47/48
CPC分类号： A61K47/48192 , A61K9/0019 , A61K31/381 , A61K31/4045 , A61K31/4462 , A61K31/4535 , A61K31/4745 , A61K31/7048 , A61K47/542 , A61K47/60 , A61K47/61
摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
摘要翻译： 本公开提供了包含聚合物和试剂的聚合物共轭物，所述试剂通过含有可水解部分的连接基与聚合物连接。
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公开(公告)号：US11944618B2
公开(公告)日：2024-04-02
申请号：US17717666
申请日：2022-04-11
发明人： Randall Moreadith , Kunsang Yoon , Zhihao Fang , Rebecca Weimer , Bekir Dizman , Tacey Viegas , Michael David Bentley
IPC分类号： A61K31/4745 , A61K9/00 , A61K31/381 , A61K31/4045 , A61K31/4462 , A61K31/4535 , A61K31/7048 , A61K47/54 , A61K47/60 , A61K47/61
CPC分类号： A61K31/4745 , A61K9/0019 , A61K31/381 , A61K31/4045 , A61K31/4462 , A61K31/4535 , A61K31/7048 , A61K47/542 , A61K47/60 , A61K47/61
摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent the agent linked to the polymer via a linking group containing a cleavable moiety.
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4.发明申请公开(公告)号：US20220193243A1
公开(公告)日：2022-06-23
申请号：US17568042
申请日：2022-01-04
摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
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公开(公告)号：US11298350B2
公开(公告)日：2022-04-12
申请号：US16588761
申请日：2019-09-30
发明人： Randall Moreadith , Kunsang Yoon , Zhihao Fang , Rebecca Weimer , Bekir Dizman , Tacey Viegas , Michael David Bentley
IPC分类号： A61K31/4745 , A61K47/60 , A61K47/54 , A61K47/61 , A61K31/381 , A61K31/4045 , A61K9/00 , A61K31/4462 , A61K31/4535 , A61K31/7048
摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
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公开(公告)号：US20190070301A1
公开(公告)日：2019-03-07
申请号：US16144358
申请日：2018-09-27
发明人： J. Milton HARRIS , Kunsang Yoon , Michael David Bentley , Zhihao Fang , Tacey Viegas , Francesco Maria Veronese , Anna Mero
IPC分类号： A61K47/59 , C07K7/08 , A61K38/27 , A61K38/33 , A61K38/17 , A61K31/727 , A61K31/728 , A61K38/10 , A61K38/18 , A61K38/19 , A61K38/47 , C08G69/48 , C12N9/96 , C07K14/62 , C07K14/535 , C07K14/505 , C07K14/47 , A61K38/42
摘要： The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
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公开(公告)号：US20150079658A1
公开(公告)日：2015-03-19
申请号：US14550571
申请日：2014-11-21
发明人： J Milton HARRIS , Michael David Bentley , Kunsang Yoon , Zhihao Fang , Francesco Maria Veronese , Tacey Viegas , Anna Mero
IPC分类号： C12N9/96 , C07K14/505 , C07K14/535 , C07K14/47 , C07K7/08 , C07K14/62
CPC分类号： A61K47/59 , A61K31/727 , A61K31/728 , A61K38/10 , A61K38/1719 , A61K38/1816 , A61K38/193 , A61K38/27 , A61K38/33 , A61K38/42 , A61K38/47 , C07K7/08 , C07K14/47 , C07K14/505 , C07K14/535 , C07K14/62 , C08G69/48 , C12N9/96 , C12Y302/01017
摘要： The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
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公开(公告)号：US10426768B2
公开(公告)日：2019-10-01
申请号：US15480122
申请日：2017-04-05
发明人： Randall Moreadith , Kunsang Yoon , Zhihao Fang , Rebecca Weimer , Bekir Dizman , Tacey Viegas , Michael David Bentley
IPC分类号： A61K31/4745 , A61K31/381 , A61K31/4045 , A61K9/00 , A61K31/4462 , A61K31/4535 , A61K31/7048 , A61K47/60 , A61K47/54 , A61K47/61
摘要： The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
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9.发明授权公开(公告)号：US10166294B2
公开(公告)日：2019-01-01
申请号：US15205671
申请日：2016-07-08
摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
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10.发明申请公开(公告)号：US20140011964A1
公开(公告)日：2014-01-09
申请号：US13961576
申请日：2013-08-07
发明人： J. Milton HARRIS , Michael David Bentley , Kunsang Yoon , Zhihao Fang , Francesco Maria Veronese , Tacey Viegas , Anna Mero
IPC分类号： A61K47/48
CPC分类号： A61K47/59 , A61K31/727 , A61K31/728 , A61K38/10 , A61K38/1719 , A61K38/1816 , A61K38/193 , A61K38/27 , A61K38/33 , A61K38/42 , A61K38/47 , C07K7/08 , C07K14/47 , C07K14/505 , C07K14/535 , C07K14/62 , C08G69/48 , C12N9/96 , C12Y302/01017
摘要： The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
摘要翻译： 本公开提供具有一定范围的活性官能团的POZ衍生物，其允许在宽范围的反应条件下将POZ衍生物与多种靶分子缀合以产生水解稳定的靶分子-POZ缀合物。 此外，本公开提供了所公开的POZ衍生物和使用所公开的末端活化单官能POZ衍生物产生的水解稳定的靶分子-POZ共轭物的新型合成方法。 在一个实施方案中，POZ衍生物是末端活化的单官能POZ衍生物。
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