公开(公告)号：US20170306155A1

公开(公告)日：2017-10-26

申请号：US15490971

申请日：2017-04-19

Applicant: SFC CO., LTD.

Inventor： Su-Jin KIM ,  Do-Min LEE ,  Jong-Tae JE

IPC: C09B49/12 ,  C07D417/08 ,  G01N21/31 ,  G01N27/447

CPC classification number: C09B49/12 ,  C07D417/08 ,  C07D498/14 ,  C07D513/14 ,  C07D513/22 ,  C07D519/00 ,  C07F5/022 ,  C12C1/02 ,  C12Q1/02 ,  C12Q1/6813 ,  C12Q1/6844 ,  G01N27/44778 ,  G01N33/52 ,  G01N2021/3155 ,  C12Q2563/107

Abstract: The present disclosure relates to a novel merocyanine-based compound capable of labeling biomolecules by intercalating biomolecules, and to a dye, kit and contrast medium composition for labelling biomolecules comprising the same.

公开(公告)号：US20200255668A1

公开(公告)日：2020-08-13

申请号：US16860982

申请日：2020-04-28

Applicant: SFC CO., LTD.

Inventor： Bong-Ki SHIN ,  Tae-Young KIM ,  Ju-man SONG ,  Hee-Jung YANG ,  Jong-Tae JE

IPC: C09B23/01 ,  C09B57/02 ,  G01N33/58

Abstract: The present invention relates to: a labeling dye having excellent fluorescent intensity and photostability; and a kit.

公开(公告)号：US20200239491A1

公开(公告)日：2020-07-30

申请号：US16848586

申请日：2020-04-14

Applicant: SFC CO., LTD.

Inventor： Bong-Ki SHIN ,  Jong-Tae JE

IPC: C07D491/147 ,  A61K49/00

Abstract: The present invention relates to: a novel merocyanine-based compound which exhibits a fluorescence signal at a visible light region of at least 380 nm, and which may be used for detecting biomolecules; and a biomolecular labeling dye, kit and contrast agent composition comprising the same.

公开(公告)号：US20200224257A1

公开(公告)日：2020-07-16

申请号：US16700618

申请日：2019-12-02

Applicant: SFC Co., Ltd.

Inventor： Goutam MASANTA ,  Bong-Ki SHIN ,  Ju-man SONG ,  Tea-hee LEE ,  Jong-Tae JE

IPC: C12Q1/6844 ,  C12Q1/6806 ,  C07D519/00

Abstract: The present disclosure relates to a quencher having a quenching effect on a fluorescent material exhibiting luminescence characteristics at an excited energy level, and various uses thereof.

公开(公告)号：US20190194730A1

公开(公告)日：2019-06-27

申请号：US16199050

申请日：2018-11-23

Applicant: SFC CO., LTD.

Inventor： Do-Min LEE ,  Seung-Soo LEE ,  Jin-Hee PARK ,  Sun-Ho KIM ,  Goutam Masanta ,  Jong-Tae JE

IPC: C12Q1/6818 ,  C07D513/06

CPC classification number: C12Q1/6818 ,  C07D513/06

Abstract: The present invention relates to a quencher having a quenching effect on a fluorescent material exhibiting luminescence characteristics at an excited energy level, and various uses thereof.

公开(公告)号：US20180203015A1

公开(公告)日：2018-07-19

申请号：US15743769

申请日：2016-07-18

Applicant: SFC CO., LTD.

Inventor： Ju-man SONG ,  Seon-Gi MIN ,  Seung-Soo LEE ,  Do-min LEE ,  Kyung-Hwa PARK ,  Moon-Chan HWANG ,  Bong-Ki SHIN ,  Jong-Tae JE

IPC: G01N33/58 ,  C09B57/00

CPC classification number: G01N33/582 ,  A61K49/0021 ,  C09B57/00 ,  C09B57/02

Abstract: The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.