公开(公告)号：US11041812B2

公开(公告)日：2021-06-22

申请号：US15870146

申请日：2018-01-12

申请人： SFC CO., LTD.

发明人： Moon-Chan Hwang ,  Jong-Tae Je

IPC分类号： G01N21/00 ,  G01N21/80 ,  C09B49/10 ,  C08L5/12 ,  C09B11/02 ,  G01N33/84 ,  C09B67/02 ,  C08B37/00 ,  C09B5/62 ,  C09B23/14 ,  C09B57/00 ,  C09B57/02 ,  G01N31/22 ,  G01N33/58

摘要： The present disclosure relates to a fluorogenic pH-sensitive dye and a film for detecting pH using the fluorogenic pH-sensitive dye on a polymer film. The fluorogenic pH-sensitive dye includes an aryl compound having a sulfonyl group (—SO2) and an agarose compound covalently bonded to the sulfonyl group (—SO2) of the aryl compound.

公开(公告)号：US10473666B2

公开(公告)日：2019-11-12

申请号：US15743769

申请日：2016-07-18

申请人： SFC CO., LTD.

发明人： Ju-man Song ,  Seon-Gi Min ,  Seung-Soo Lee ,  Do-min Lee ,  Kyung-Hwa Park ,  Moon-Chan Hwang ,  Bong-Ki Shin ,  Jong-Tae Je

IPC分类号： C09B23/01 ,  C09B57/00 ,  G01N33/58 ,  A61K49/00

摘要： The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.

公开(公告)号：US20180231471A1

公开(公告)日：2018-08-16

申请号：US15870146

申请日：2018-01-12

申请人： SFC CO., LTD.

发明人： Moon-Chan Hwang ,  Jong-Tae Je

IPC分类号： G01N21/80 ,  C09B49/10 ,  C08L5/12

CPC分类号： G01N21/80 ,  C08B37/0039 ,  C08L5/12 ,  C09B5/62 ,  C09B11/02 ,  C09B23/14 ,  C09B23/141 ,  C09B49/10 ,  C09B57/001 ,  C09B57/02 ,  C09B67/0097 ,  G01N31/221 ,  G01N33/582 ,  G01N33/84

摘要： The present disclosure relates to a fluorogenic pH-sensitive dye including an aryl compound having a sulfonyl group (—SO2); and an agarose compound covalently bonded to the sulfonyl group (—SO2) of the aryl compound.