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公开(公告)号：US10316008B2
公开(公告)日：2019-06-11
申请号：US15870276
申请日：2018-01-12
Inventor： Fajun Nan , Min Li , Zhaobing Gao , Yangming Zhang , Haining Hu , Haiyan Xu , Huanan Liu , Xiaoping Pi
IPC: C07D307/24 , A61K31/167 , A61K31/17 , A61K31/27 , A61K31/277 , A61K31/341 , C07C269/04 , C07C269/06 , C07C271/28 , C07C273/18 , C07C275/64 , C07C231/02 , C07C333/08 , C07C233/62 , C07C235/16 , C07C235/74 , C07C237/04 , C07C237/22 , C07C237/48
Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
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公开(公告)号：US20180134677A1
公开(公告)日：2018-05-17
申请号：US15870276
申请日：2018-01-12
Inventor： Fajun Nan , Min Li , Zhaobing Gao , Yangming Zhang , Haining Hu , Haiyan Xu , Huanan Liu , Xiaoping Pi
IPC: C07D307/24 , A61K31/167 , C07C237/22 , C07C237/04 , C07C235/74 , C07C235/16 , C07C233/62 , C07C333/08 , C07C231/02 , C07C275/64 , C07C273/18 , C07C271/28 , C07C269/06 , C07C269/04 , A61K31/341 , A61K31/277 , A61K31/27 , A61K31/17 , C07C237/48
CPC classification number: C07D307/24 , A61K31/167 , A61K31/17 , A61K31/27 , A61K31/277 , A61K31/341 , C07C231/02 , C07C233/62 , C07C235/16 , C07C235/74 , C07C237/04 , C07C237/22 , C07C237/48 , C07C269/04 , C07C269/06 , C07C271/28 , C07C273/18 , C07C275/64 , C07C333/08 , C07C2601/02 , C07C2601/14
Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
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公开(公告)号：US10077245B2
公开(公告)日：2018-09-18
申请号：US15306971
申请日：2015-04-22
Inventor： Fajun Nan , Min Li , Zhaobing Gao , Yangming Zhang , Haining Hu , Haiyan Xu , Huanan Liu , Xiaoping Pi
IPC: C07C235/16 , C07C271/28 , C07D307/24 , A61K31/167 , A61K31/17 , A61K31/27 , A61K31/277 , A61K31/341 , C07C269/04 , C07C269/06 , C07C273/18 , C07C275/64 , C07C231/02 , C07C333/08 , C07C233/62 , C07C235/74 , C07C237/04 , C07C237/22 , C07C237/48
CPC classification number: C07D307/24 , A61K31/167 , A61K31/17 , A61K31/27 , A61K31/277 , A61K31/341 , C07C231/02 , C07C233/62 , C07C235/16 , C07C235/74 , C07C237/04 , C07C237/22 , C07C237/48 , C07C269/04 , C07C269/06 , C07C271/28 , C07C273/18 , C07C275/64 , C07C333/08 , C07C2601/02 , C07C2601/14
Abstract: The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.
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