公开(公告)号：US20200010492A1

公开(公告)日：2020-01-09

申请号：US16490837

申请日：2016-02-28

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Fajun NAN ,  Xin XIE ,  Linhai CHEN ,  Qing ZHANG ,  Yufeng XIAO ,  Hui YANG

IPC: C07F9/09 ,  C07F9/6561 ,  C07F9/6553 ,  C07F9/655

Abstract: The present invention relates to a GPR84 receptor antagonist and use thereof. The GPR84 receptor antagonist of the present invention has a structure as represented by formula (I), the definitions of R1, R2, R3, R4, L1, L2, L3, L4, L5, L6, Y, Z, and rings A, B, C, and D are as described in the description and claims. The GPR84 receptor antagonist of the present invention can competitively inhibit the activation of the receptor caused by an agonist of GPR84, and can be used in the preparation of a medicament for treating related diseases caused by high expression or high excitability of GPR84 receptor, the diseases including multiple sclerosis, inflammatory bowel disease, arthritis and the like.

公开(公告)号：US20170143717A1

公开(公告)日：2017-05-25

申请号：US14916463

申请日：2014-05-16

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Qiang YU ,  Jing HE ,  Qing ZHANG

IPC: A61K31/5025 ,  C12N5/09

CPC classification number: A61K31/5025 ,  C12N5/0693 ,  C12N2501/06

Abstract: The present invention provides an anti-tumor use of Anagrelide and derivatives thereof and, more specifically, the present invention provides the use of Anagrelide and derivatives thereof in the preparation of pharmaceuticals or pharmaceutical compositions for the treatment or inhibition of tumors.

公开(公告)号：US20180237399A1

公开(公告)日：2018-08-23

申请号：US15772105

申请日：2016-11-01

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Fajun NAN ,  Xin XIE ,  Yang LIU ,  Qing ZHANG ,  Linhai CHEN ,  Hui YANG

IPC: C07D239/60 ,  C07D239/52 ,  C07D213/69 ,  C07C49/825 ,  C07C39/19

CPC classification number: C07D239/60 ,  A61K31/505 ,  C07C39/08 ,  C07C39/19 ,  C07C49/825 ,  C07D213/69 ,  C07D239/48 ,  C07D239/52 ,  C07D239/54 ,  C07D239/545 ,  C07D239/56 ,  C07D251/20 ,  C07D309/38

Abstract: The present invention relates to a class of compounds represented by the formula I, or pharmaceutically acceptable salts thereof, methods for their preparation, and application as small molecule tools that function as GPR84 agonists, and their use in preparing a medicament for the treatment of septicemia.