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1.发明授权公开(公告)号：US10138275B2
公开(公告)日：2018-11-27
申请号：US15314799
申请日：2015-05-29
发明人： Shidong Liu , Xiusheng Wang , Zhijun Tang , Xiaoming Ji
摘要： Disclosed is a crystalline powder of a cyclic peptide compound, represented by formula I is the structure of same, and, also disclosed are a preparation method for same and uses thereof.
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公开(公告)号：US10138274B2
公开(公告)日：2018-11-27
申请号：US15314797
申请日：2015-05-29
发明人： Shidong Liu , Xiusheng Wang , Jicheng Hu , Xiaoming Ji
摘要： Disclosed is a novel polymorph of a cyclic peptide compound, the structure whereof is represented by formula I; also disclosed are a preparation method for same and uses thereof.
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3.发明申请HIGH-PURITY CYCLOPEPTIDE CRYSTAL AS WELL AS PREPARATION METHOD AND USE THEREOF 有权高纯度环孢菌素晶体作为制备方法及其用途公开(公告)号：US20150105331A1
公开(公告)日：2015-04-16
申请号：US14389352
申请日：2013-03-29
发明人： Shidong Liu , Zhaoli Zhang , Xiusheng Wang , Xiao Zhang , Zhijun Tang , Xiaoming Ji
IPC分类号： C07K7/56
摘要： A high purity cyclopeptide crystal has a structure shown by Formula I. R represents H or a cation forming a pharmaceutically acceptable salt. Also disclosed are a preparation method and a use of the high-purity cyclopeptide crystal.
摘要翻译： 高纯度环肽结构具有式I所示的结构.R表示H或形成药学上可接受的盐的阳离子。 还公开了高纯度环肽晶体的制备方法和用途。
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4.发明授权公开(公告)号：US11518990B2
公开(公告)日：2022-12-06
申请号：US16741460
申请日：2020-01-13
发明人： Shidong Liu , Zhaoli Zhang , Xiaoming Ji
摘要： Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.
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公开(公告)号：US10183973B2
公开(公告)日：2019-01-22
申请号：US15314458
申请日：2015-05-29
发明人： Shidong Liu , Xiusheng Wang , Xiaoming Ji
摘要： Provided in the invention is a solvate of a cyclic peptide compound, represented by formula I is the structural formula of the cyclic peptide compound, and, also disclosed are a preparation method for same and uses thereof.
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6.发明授权公开(公告)号：US09580470B2
公开(公告)日：2017-02-28
申请号：US14389352
申请日：2013-03-29
发明人： Shidong Liu , Zhaoli Zhang , Xiusheng Wang , Xiao Zhang , Zhijun Tang , Xiaoming Ji
摘要： A high purity cyclopeptide crystal has a structure shown by Formula I. R represents H or a cation forming a pharmaceutically acceptable salt. Also disclosed are a preparation method and a use of the high-purity cyclopeptide crystal.
摘要翻译： 高纯度环肽结构具有式I所示的结构.R表示H或形成药学上可接受的盐的阳离子。 还公开了高纯度环肽晶体的制备方法和用途。
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7.发明申请IMMOBILIZED CYCLOALIPHATIC PEPTIDE ACYLTRANSFERASE AND PREPARATION METHOD AND USES THEREOF 审中-公开固定化环磷酰胆碱酯酶及其制备方法及其用途公开(公告)号：US20150140604A1
公开(公告)日：2015-05-21
申请号：US14400473
申请日：2013-05-10
发明人： Shidong Liu , Zhaoli Zhang , Xiaoming Ji
摘要： Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.
摘要翻译： 在本发明中公开了固定化脂环族肽酰基转移酶及其制备方法和用途。 脂环族肽酰基转移酶固定在载体上; 脂环族肽酰基转移酶衍生自天然或人工突变体或其变体，或者可以通过引入外源环酰基转移酶基因并在此后进行转化获得; 载体的材料选自无机载体或聚丙烯树脂载体。 本发明还公开了固定化脂环族肽酰基转移酶的制备方法及其用途。
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8.发明申请HYDRATE OF CYCLOPEPTIDE COMPOUND AS WELL AS PREPARATION METHOD AND USE THEREOF 审中-公开环己酮化合物的水合物作为制备方法及其用途公开(公告)号：US20150057234A1
公开(公告)日：2015-02-26
申请号：US14389354
申请日：2013-03-29
发明人： Shidong Liu , Zhaoli Zhang , Xiusheng Wang , Xiao Zhang , Zhijun Tang , Xiaoming Ji
IPC分类号： C07K7/64
摘要： Disclosed is a hydrate of a compound as shown in Formula I. In formula I, R represents H or a cation capable of forming a pharmaceutically acceptable salt. The mass percentage of water in the hydrate is more than 8%. The hydrate has good stability. Moreover, disclosed are a preparation method and a use thereof.
摘要翻译： 公开了式I所示的化合物的水合物。在式I中，R表示H或能形成药学上可接受的盐的阳离子。 水合物中水的质量百分比大于8％。 水合物具有良好的稳定性。 此外，公开了其制备方法和用途。
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