-
公开(公告)号：US20240262864A1
公开(公告)日：2024-08-08
申请号：US18006110
申请日：2022-06-17
发明人： Rongguo SHI , Min CHEN , Yushan GUO , Yan LI , Xiaoming JI
摘要： The present disclosure provides an echinocandin drug impurity and preparation and purification methods and use thereof. The echinocandin drug impurity has a structure shown in Formula I:
In the present disclosure, micafungin sodium is reacted with a protonic acid aqueous solution to obtain an echinocandin drug impurity, and a high-purity echinocandin drug impurity is obtained after chromatographic purification. The present disclosure overcomes problems that an echinocandin drug impurity is prone to being degraded during the purification, and purification difficulty is high, and an HPLC purity of the obtained echinocandin drug impurity may reach 90% or more. The echinocandin drug impurity may be used as a reference substance for establishing an analysis method for use in echinocandin drug quality control.-
2.发明申请公开(公告)号：US20170101443A1
公开(公告)日：2017-04-13
申请号：US15314799
申请日：2015-05-29
发明人： Shidong LIU , Xiusheng WANG , Zhijun TANG , Xiaoming JI
IPC分类号： C07K7/56
摘要： Disclosed is a crystalline powder of a cyclic peptide compound, represented by formula I is the structure of same, and, also disclosed are a preparation method for same and uses thereof.
-
3.发明授权Crystal form of prostaglandin analogue, and preparation method and use thereof 有权前列腺素类似物的晶体形式及其制备方法和用途公开(公告)号：US09278903B2
公开(公告)日：2016-03-08
申请号：US14371405
申请日：2013-01-10
发明人： Zhijun Tang , Yubin Liu , Bingming He , Jun Yang , Xiaoming Ji
CPC分类号： C07C59/72 , C07C51/43 , C07C2603/14
摘要： Provided are a crystal form A of a compound having the structure as represented by formula I, and preparation method and use thereof. The X-ray powder diffraction (XRPD) chart of the crystal form A has characteristic peaks at the following diffraction angles: 2.9±0.2°, 13.6±0.2°, 17.3±0.2° and 18.6±0.2°.
摘要翻译： 提供具有式I所示结构的化合物的结晶形式A及其制备方法和用途。 晶体形式A的X射线粉末衍射图（XRPD）在以下衍射角具有特征峰：2.9±0.2°，13.6±0.2°，17.3±0.2°和18.6±0.2°。
-
4.发明授权公开(公告)号：US10138275B2
公开(公告)日：2018-11-27
申请号：US15314799
申请日：2015-05-29
发明人： Shidong Liu , Xiusheng Wang , Zhijun Tang , Xiaoming Ji
摘要： Disclosed is a crystalline powder of a cyclic peptide compound, represented by formula I is the structure of same, and, also disclosed are a preparation method for same and uses thereof.
-
公开(公告)号：US20170190742A1
公开(公告)日：2017-07-06
申请号：US15314452
申请日：2015-05-29
发明人： Shidong LIU , Xiusheng WANG , Xiaoming JI
IPC分类号： C07K7/56
摘要： Disclosed is a composition of a cyclic peptide compound having a water content of 3%-20%, represented by formula I is the structural formula of the cyclic peptide compound, and, also disclosed are a preparation method for same and uses thereof.
-
公开(公告)号：US09149502B2
公开(公告)日：2015-10-06
申请号：US14346268
申请日：2012-09-25
发明人： Yunhai Hong , Ying Xue , Lixin Sha , Xiaoming Ji
摘要： Disclosed is a low impurity content caspofungin pharmaceutical composition and a method for preparing the low impurity content caspofungin pharmaceutical composition. The caspofungin pharmaceutical composition comprises the compound of formula I and/or a pharmaceutically acceptable salt thereof, in combination with a saccharide protective agent(s) and an amino acid(s). The caspofungin pharmaceutical composition is prepared by dissolving the saccharide protective agent and the amino acid into water or a suitable buffer solution; adding the caspofungin compound and dissolving it; filtering the solution and lyophilizing.
-
7.发明申请CRYSTAL FORM OF PROSTAGLANDIN ANALOGUE, AND PREPARATION METHOD AND USE THEREOF 有权前列腺素类似物的晶体形式及其制备方法及其用途公开(公告)号：US20150005384A1
公开(公告)日：2015-01-01
申请号：US14371405
申请日：2013-01-10
发明人： Zhijun Tang , Yubin Liu , Bingming He , Jun Yang , Xiaoming Ji
CPC分类号： C07C59/72 , C07C51/43 , C07C2603/14
摘要： Provided are a crystal form A of a compound having the structure as represented by formula I, and preparation method and use thereof. The X-ray powder diffraction (XRPD) chart of the crystal form A has characteristic peaks at the following diffraction angles: 2.9±0.2°, 13.6±0.2°, 17.3±0.2° and 18.6±0.2°.
摘要翻译： 提供具有式I所示结构的化合物的结晶形式A及其制备方法和用途。 晶体形式A的X射线粉末衍射图（XRPD）在以下衍射角具有特征峰：2.9±0.2°，13.6±0.2°，17.3±0.2°和18.6±0.2°。
-
公开(公告)号：US10138274B2
公开(公告)日：2018-11-27
申请号：US15314797
申请日：2015-05-29
发明人： Shidong Liu , Xiusheng Wang , Jicheng Hu , Xiaoming Ji
摘要： Disclosed is a novel polymorph of a cyclic peptide compound, the structure whereof is represented by formula I; also disclosed are a preparation method for same and uses thereof.
-
公开(公告)号：US20170198013A1
公开(公告)日：2017-07-13
申请号：US15314797
申请日：2015-05-29
发明人： Shidong LIU , Xiusheng WANG , Jicheng HU , Xiaoming JI
摘要： Disclosed is a novel polymorph of a cyclic peptide compound, the structure whereof is represented by formula I; also disclosed are a preparation method for same and uses thereof.
-
公开(公告)号：US20170198012A1
公开(公告)日：2017-07-13
申请号：US15314458
申请日：2015-05-29
发明人： Shidong LIU , Xiusheng WANG , Xiaoming JI
摘要： Provided in the invention is a solvate of a cyclic peptide compound, represented by formula I is the structural formula of the cyclic peptide compound, and, also disclosed are a preparation method for same and uses thereof.
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.016 秒)
