公开(公告)号：US20180284075A1

公开(公告)日：2018-10-04

申请号：US15885902

申请日：2018-02-01

Applicant: SHIMADZU CORPORATION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Noriyuki OJIMA ,  Shuichi KAWANA ,  Yumi UNNO ,  Takero SAKAI ,  Kenichi OBAYASHI ,  Yukihiko KUDO ,  Katsuyuki TANEDA ,  Masaru YOSHIDA ,  Shin NISHIUMI ,  Takashi KOBAYASHI ,  Takeshi AZUMA

IPC: G01N30/06 ,  G01N30/72 ,  G01N1/40 ,  G01N33/487 ,  H01J49/00 ,  G01N30/86

Abstract: At least one stable isotope reagent is added to each biological sample and standard sample to prepare biological samples for analysis and standard sample for analysis. The quality of the biological samples is evaluated using data of one set of biological samples for analysis composed of a plurality of biological samples for analysis. Besides, the quality of a pretreatment and/or analysis of each set of samples for analysis is evaluated using data obtained by analyzing the standard sample for analysis before and after an analysis of one set of samples for analysis. An abnormality in a chromatograph or mass analyzer used for the analysis of one set of samples is evaluated by the data obtained by analyzing a sample for device evaluation before and after the analysis of one set of samples for analysis. Thus, the quality of data obtained by chromatographic mass spectrometry on biological samples is comprehensively evaluated.

公开(公告)号：US20220146526A1

公开(公告)日：2022-05-12

申请号：US17437720

申请日：2020-01-27

Applicant: SHIMADZU CORPORATION

Inventor： Yumi UNNO ,  Shuichi KAWANA ,  Yutaka AOKI ,  Junichi MASUDA ,  Hirotaka FUJIMOTO ,  Tsuyoshi NAKANISHI

IPC: G01N33/68 ,  G01N33/70 ,  G01N33/92 ,  G01N30/72

Abstract: A method for evaluating a sample includes obtaining a blood plasma sample prepared from human blood, conducting detection of a predetermined molecule in the blood plasma sample, and evaluating the quality of the blood plasma sample based on the intensity of the molecule acquired by the detection.

公开(公告)号：US20180299448A1

公开(公告)日：2018-10-18

申请号：US15887011

申请日：2018-02-02

Applicant: SHIMADZU CORPORATION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  NATIONAL CANCER CENTER

Inventor： Noriyuki OJIMA ,  Shuichi KAWANA ,  Yumi UNNO ,  Takero SAKAI ,  Kenichi OBAYASHI ,  Yukihiko KUDO ,  Masaru YOSHIDA ,  Shin NISHIUMI ,  Takashi KOBAYASHI ,  Takeshi AZUMA ,  Koji OKAMOTO ,  Yasuhide YAMADA ,  Natsuko OKITA ,  Kazuki SUDO

IPC: G01N33/574 ,  G01N33/49

Abstract: Provided is a colorectal cancer inspection method by which the presence of early colorectal cancer at any one of stages from 0 to 2 can be accurately determined. The colorectal cancer inspection method includes: measuring the amounts of at least lactic acid, pyruvic acid, and glycolic acid among a plurality of kinds of in vivo metabolites contained in a biological sample collected from a test subject, based on data obtained by performing a chromatograph-MS/MS analysis on the biological sample; and determining the presence of colorectal cancer at any one of stages from 0 to 2, based on a measurement value of at least one of the lactic acid, the pyruvic acid, and the glycolic acid.