公开(公告)号：US20140132607A1

公开(公告)日：2014-05-15

申请号：US13678088

申请日：2012-11-15

Applicant: SHIMADZU CORPORATION

Inventor： Shuichi KAWANA

IPC: G06T11/20

CPC classification number: G06T11/206 ,  G01N30/72 ,  G01N30/8624 ,  G01N30/8675

Abstract: A measurement EIC for quantitative ions and a measurement EIC for ions to be confirmed in the vicinity of the retention time of a target compound are displayed in an overlapping manner in a chromatogram display area. In addition, a standard center line corresponding to a standard value of the confirmation ion ratio, which expresses the ratio of the intensity of the confirmation ions to the intensity of the quantitative ions in the target compound and an upper limit line and a lower limit line demonstrating the permissible range of the intensity of the confirmation ions are displayed in an overlapping manner on the EIC. An analyst determines whether a peak used for identification originates from the target compound by determining whether the top of an EIC peak of the confirmation ions falls between the upper limit line and the lower limit line.

Abstract translation: 用于定量离子的测量EIC和在目标化合物的保留时间附近确认的离子的测量EIC以重叠的方式显示在色谱图显示区域中。 此外，对应于确认离子比的标准值的标准中心线，其表示确认离子的强度与目标化合物中的定量离子的强度的比，以及上限线和下限线 证明确认离子强度的允许范围以重叠的方式显示在EIC上。 分析人员通过确定确认离子的EIC峰的顶部是否落在上限线和下限线之间来确定用于鉴别的峰是否源于目标化合物。

公开(公告)号：US20180284075A1

公开(公告)日：2018-10-04

申请号：US15885902

申请日：2018-02-01

Applicant: SHIMADZU CORPORATION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Noriyuki OJIMA ,  Shuichi KAWANA ,  Yumi UNNO ,  Takero SAKAI ,  Kenichi OBAYASHI ,  Yukihiko KUDO ,  Katsuyuki TANEDA ,  Masaru YOSHIDA ,  Shin NISHIUMI ,  Takashi KOBAYASHI ,  Takeshi AZUMA

IPC: G01N30/06 ,  G01N30/72 ,  G01N1/40 ,  G01N33/487 ,  H01J49/00 ,  G01N30/86

Abstract: At least one stable isotope reagent is added to each biological sample and standard sample to prepare biological samples for analysis and standard sample for analysis. The quality of the biological samples is evaluated using data of one set of biological samples for analysis composed of a plurality of biological samples for analysis. Besides, the quality of a pretreatment and/or analysis of each set of samples for analysis is evaluated using data obtained by analyzing the standard sample for analysis before and after an analysis of one set of samples for analysis. An abnormality in a chromatograph or mass analyzer used for the analysis of one set of samples is evaluated by the data obtained by analyzing a sample for device evaluation before and after the analysis of one set of samples for analysis. Thus, the quality of data obtained by chromatographic mass spectrometry on biological samples is comprehensively evaluated.

公开(公告)号：US20140352406A1

公开(公告)日：2014-12-04

申请号：US13905652

申请日：2013-05-30

Applicant: SHIMADZU CORPORATION

Inventor： Shuichi KAWANA

IPC: G01N30/38

CPC classification number: G01N30/38 ,  G01N2030/324 ,  G01N2030/385

Abstract: A gas chromatograph having a column which separates respective components contained in a gas sample introduced via a carrier gas over time, wherein an analysis mode and a standby mode can be switched and executed. The gas chromatograph apparatus comprises: a carrier gas flow path, a column protection gas flow path, a flow path switching part provided between the carrier gas flow path and the column protection gas flow path and a column so that only one of the carrier gas or a column protection gas is introduced into the column, and a flow path control part for controlling the flow switching part so as to introduce the carrier gas into the column at the time of the analysis mode and introduce the column protection gas into the column at the time of the standby mode.

Abstract translation: 一种气相色谱仪，其具有分离随着时间经由载气引入的气体样品中所含的各成分的柱，其中可以切换并执行分析模式和待机模式。 气相色谱装置包括：载气流路，柱保护气流路径，设置在载气流路和柱保护气流路之间的流路切换部，以及列，仅使一个载气或 柱保护气体被引入塔中，流路控制部分用于控制流动切换部分，以便在分析模式时将载气引入塔中，并将塔保护气体引入塔中 待机模式的时间。

公开(公告)号：US20220146526A1

公开(公告)日：2022-05-12

申请号：US17437720

申请日：2020-01-27

Applicant: SHIMADZU CORPORATION

Inventor： Yumi UNNO ,  Shuichi KAWANA ,  Yutaka AOKI ,  Junichi MASUDA ,  Hirotaka FUJIMOTO ,  Tsuyoshi NAKANISHI

IPC: G01N33/68 ,  G01N33/70 ,  G01N33/92 ,  G01N30/72

Abstract: A method for evaluating a sample includes obtaining a blood plasma sample prepared from human blood, conducting detection of a predetermined molecule in the blood plasma sample, and evaluating the quality of the blood plasma sample based on the intensity of the molecule acquired by the detection.

公开(公告)号：US20180299448A1

公开(公告)日：2018-10-18

申请号：US15887011

申请日：2018-02-02

Applicant: SHIMADZU CORPORATION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  NATIONAL CANCER CENTER

Inventor： Noriyuki OJIMA ,  Shuichi KAWANA ,  Yumi UNNO ,  Takero SAKAI ,  Kenichi OBAYASHI ,  Yukihiko KUDO ,  Masaru YOSHIDA ,  Shin NISHIUMI ,  Takashi KOBAYASHI ,  Takeshi AZUMA ,  Koji OKAMOTO ,  Yasuhide YAMADA ,  Natsuko OKITA ,  Kazuki SUDO

IPC: G01N33/574 ,  G01N33/49

Abstract: Provided is a colorectal cancer inspection method by which the presence of early colorectal cancer at any one of stages from 0 to 2 can be accurately determined. The colorectal cancer inspection method includes: measuring the amounts of at least lactic acid, pyruvic acid, and glycolic acid among a plurality of kinds of in vivo metabolites contained in a biological sample collected from a test subject, based on data obtained by performing a chromatograph-MS/MS analysis on the biological sample; and determining the presence of colorectal cancer at any one of stages from 0 to 2, based on a measurement value of at least one of the lactic acid, the pyruvic acid, and the glycolic acid.

公开(公告)号：US20140116111A1

公开(公告)日：2014-05-01

申请号：US13661395

申请日：2012-10-26

Applicant: SHIMADZU CORPORATION

Inventor： Katsuyuki TANEDA ,  Shuichi KAWANA

IPC: G01N30/72

CPC classification number: G01N30/18 ,  G01N30/10 ,  G01N30/7206 ,  G01N2030/126

Abstract: A gas chromatograph mass spectrometer including: an oven for gas chromatography, a mass spectrometry part, a sample vaporization chamber, a gas supply part, and a control part. When the replacement operation of a septum or a glass insert begins, the control part controls the gas supply part so that the flow rate of a carrier gas has a constant pressure and then controls heaters so that temperature is equal to or less than a temperature at which replacement is possible. When temperature becomes equal to or less than the temperature at which replacement is possible and the replacement operation of the septum or the glass insert is completed, the control part controls the heaters so that the temperature is an analysis temperature and controls the gas supply part to employ the same control method for the flow rate of the carrier gas as that before the replacement operation is begun.

Abstract translation: 一种气相色谱质谱仪，包括：用于气相色谱的烘箱，质谱部分，样品蒸发室，气体供应部分和控制部分。 当隔垫或玻璃插入件的更换操作开始时，控制部分控制气体供应部分，使得载气的流量具有恒定的压力，然后控制加热器，使得温度等于或小于 哪个更换是可能的。 当温度变得等于或小于更换可能的温度并且隔膜或玻璃插入件的更换操作完成时，控制部分控制加热器，使得温度为分析温度，并将气体供应部分控制到 采用与替换操作开始前的载气流速相同的控制方法。