公开(公告)号：US20240060024A1

公开(公告)日：2024-02-22

申请号：US18259250

申请日：2021-12-23

Applicant: SHINSHU UNIVERSITY ,  STELLA CHEMIFA CORPORATION

Inventor： Naoto SAITO ,  Takeshi UEMURA ,  Kazutoshi HISANO ,  Yoshinori SATO ,  Masashi YAMAMOTO ,  Keiichi NII ,  Tetsuo NISHIDA

IPC: C12M1/00 ,  C08J7/12

CPC classification number: C12M23/20 ,  C08J7/123

Abstract: Provided are a cell culture member having excellent cell culture performance and its long-term stability, and a method for modifying the surface thereof. The cell culture member according to the present invention is a cell culture member having at least a holding region that holds an adherent cell and contains a polymer compound, wherein at least a part of the holding region is a surface-modified region in which a functional group containing a nitrogen atom is directly chemically bonded to a part of carbon atoms and/or silicon atoms constituting the polymer compound, and the present invention can provide a cell culture member that improves adhesiveness of the adherent cell to the surface-modified region, suppresses deterioration over time of adhesiveness, and is excellent in cell culture performance and its long-term stability.

公开(公告)号：US20240052299A1

公开(公告)日：2024-02-15

申请号：US18259237

申请日：2021-12-23

Applicant: SHINSHU UNIVERSITY ,  STELLA CHEMIFA CORPORATION

Inventor： Naoto SAITO ,  Takeshi UEMURA ,  Kazutoshi HISANO ,  Yoshinori SATO ,  Masashi YAMAMOTO ,  Keiichi NII ,  Tetsuo NISHIDA

IPC: C12N5/00 ,  C12M1/12 ,  C08J7/12

CPC classification number: C12N5/0068 ,  C12M25/04 ,  C08J7/12 ,  C12N2509/00 ,  C12N2533/30 ,  C12N2537/00 ,  C08J2325/06

Abstract: Provided are a cell culture member having excellent cell culture performance and its long-term stability, and a method for modifying the surface thereof. The cell culture member according to the present invention is a cell culture member having at least a holding region that holds an adherent cell and contains a polymer compound, wherein at least a part of the holding region is a surface-modified region in which a fluorine atom is directly chemically bonded to a part of carbon atoms and/or silicon atoms constituting the polymer compound, and the present invention can provide a cell culture member that improves adhesiveness of the adherent cell to the surface-modified region, suppresses deterioration over time of adhesiveness, and is excellent in cell culture performance and its long-term stability.