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    Aroyl alkyledene thiazolines
    1.
    发明授权
    Aroyl alkyledene thiazolines 失效
    芳酰基亚烷基噻唑啉

    公开(公告)号：US3928327A

    公开(公告)日：1975-12-23

    申请号：US50935474

    申请日：1974-09-24

    申请人： SHIONOGI & CO

    发明人： TAKAMIZAWA AKIRA ,  HARADA HIROSHI

    IPC分类号： C07D277/24 ,  C07D277/64 ,  C07D417/06 ,  C07D239/04 ,  C07D277/10 ,  C07D417/04

    CPC分类号： C07D277/24

    摘要： Thiazoline derivatives of the general formula:
    wherein R1 is a lower alkyl group, lower alkenyl group, lower alkynyl group, aralkyl group or (4-amino-2-methyl-5pyrimidinyl)methyl group, R2 is a hydrogen atom or lower alkyl group, R3 is a hydrogen atom or aryl group, and R4 is an aryl group, being useful as medicaments exhibiting analgesic and antiinflammatory actions which can be produced by reaction of 2methylthiazolium derivatives with aroylphosphonates.

    摘要翻译： 具有以下通式的噻唑啉衍生物：R4-C = O | CH并列角R1-NS其中R1是低级烷基，低级烯基，低级炔基，芳烷基或（4-氨基-2-甲基-5-嘧啶基 ）甲基，R2是氢原子或低级烷基，R3是氢原子或芳基，R4是芳基，可用作表现出镇痛和抗炎作用的药物，其可以通过2- 具有芳酰基膦酸盐的甲基噻唑鎓衍生物。

    1,3-dithiol compounds
    3.
    发明授权
    1,3-dithiol compounds 失效
    1,3-DITHIOL化合物

    公开(公告)号：US3679677A

    公开(公告)日：1972-07-25

    申请号：US3679677D

    申请日：1970-02-11

    申请人： SHIONOGI & CO

    发明人： TAKAMIZAWA AKIRA ,  HIRAI KENTARO

    IPC分类号： C07D339/06 ,  A01N43/28 ,  A61K27/00 ,  C07D71/00 ,  C07D87/46

    CPC分类号： C07D409/04

    摘要： A 1,3-dithiol compound represented by the formula:

    WHEREIN R and R'' represent each hydrogen, lower alkyl, aryl or ar(lower)alkyl and R'''' represents hydroxy, lower alkoxy, (lower)alkylthio, aryloxy, arylthio, ar(lower)alkoxy, ar(lower)alkylthio or (mono- or disubstituted)aminothiocarbonylthio, being useful as antibacterial, antifungal, anti-inflammatory, insecticidal, miticidal agents or their intermediates, is prepared from a 1,3-di-thiol-2-ylidenammonium salt in 3 steps.

    摘要翻译： 由下式表示的1,3-二硫醇化合物：

    Thiol-type thiamine thionothiolcarbonates
    4.
    发明授权
    Thiol-type thiamine thionothiolcarbonates 失效
    THIOL型甲硫氨酸硫酸酯

    公开(公告)号：US3666831A

    公开(公告)日：1972-05-30

    申请号：US3666831D

    申请日：1969-02-17

    申请人： SHIONOGI & CO

    发明人： TAKAMIZAWA AKIRA ,  HIRAI KENTARO

    IPC分类号： A01D87/12 ,  A61K31/51 ,  C07D415/00 ,  C07D51/42

    CPC分类号： C07D415/00 ,  A61K31/51 ,  Y10S514/87

    摘要： Thiol-type thiamine thionothiolcarbonates, i.e. O-(lower)alkoxycarbonyl-S-(substituted or unsubstituted)phenylthiothiocarbonylthiamines, being prepared from S-alkali salts of O-(lower)-alkoxycarbonylthiamines by an interaction with (substituted or unsubstituted)-phenylthiothiocarbonyl groupintroducing agents, or from S-alkali salts of thiamine by an interaction with the (substituted or unsubstituted)phenylthiothiocarbonyl group-introducing agents followed by alkoxycarbonylation of the O-position, possessing antiinflammatory activity and also rapid, prolonged and high level vitamin B1 activity, and being sufficiently stable for various pharmaceutical preparations.

    摘要翻译： 硫醇型硫胺硫醇硫醇碳酸酯，即O-（低级） - 烷氧基羰基-S-（取代或未取代的） - 苯基硫代羰基噻吩，由O-（低级） - 烷氧基羰基噻吩的S-碱式盐与（取代或未取代的） - 苯硫基羰基引入剂，或硫胺素的S-碱盐与（取代或未取代的） - 苯基硫代羰基引入剂的相互作用，然后进行O-位的烷氧基羰基化，具有抗炎活性，并且快速，延长和 高水平的维生素B1活性，并且对于各种药物制剂是足够稳定的。