公开(公告)号：US20170014444A1

公开(公告)日：2017-01-19

申请号：US15124767

申请日：2014-03-12

Applicant: Shiseido Company, Ltd

Inventor： Junichi HOSOI ,  Kaori INOUE ,  Shoko YAMADA ,  Minako SATO

IPC: A61K31/716 ,  A61K36/738 ,  A61K31/77

CPC classification number: A61K31/716 ,  A61K31/77 ,  A61K36/738 ,  A61K2300/00

Abstract: An object of the present invention is to provide an agent for sedating the response of skin to external stimulation. The aforementioned object was achieved by finding a component that promotes CD39 gene expression in Langerhans cells. More specifically, the present invention is based on the finding that the combination of carboxymethyl-beta glucan or a salt thereof polyoxyethylene (POE)/polyoxypropylene (POP) random copolymer dimethyl ether and rosewater promotes CD39 gene expression.

Abstract translation: 本发明的目的是提供一种用于镇静皮肤对外部刺激的反应的药剂。 上述目的是通过在朗格汉斯细胞中发现促进CD39基因表达的成分来实现的。 更具体地，本发明是基于以下发现：羧甲基β葡聚糖或其盐的聚氧乙烯（POE）/聚氧丙烯（POP）无规共聚物二甲醚和rosewater的组合促进CD39基因表达。

公开(公告)号：US20230172837A1

公开(公告)日：2023-06-08

申请号：US17919954

申请日：2021-04-19

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Satoshi HORIBA ,  Junichi HOSOI ,  Daigo INOUE ,  Kentaro KAJIYA ,  Masaya TAKAGI ,  Yuko MATSUURA ,  Masato IINO

IPC: A61K8/9761 ,  A61Q19/02 ,  A61Q19/08 ,  A45D44/22

CPC classification number: A61K8/9761 ,  A61Q19/02 ,  A61Q19/08 ,  A45D44/22

Abstract: The present invention provides an agent for preventing and/or improving photoaging and/or dermal pigmentation comprising Thujae Semen extract as an active ingredient. The present invention also provides a cosmetic method which includes a step for applying the agent for preventing and/or improving photoaging and/or dermal pigmentation to skin to be treated, and a cosmetic device to be applied in said method.