公开(公告)号：US20230172837A1

公开(公告)日：2023-06-08

申请号：US17919954

申请日：2021-04-19

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Satoshi HORIBA ,  Junichi HOSOI ,  Daigo INOUE ,  Kentaro KAJIYA ,  Masaya TAKAGI ,  Yuko MATSUURA ,  Masato IINO

IPC: A61K8/9761 ,  A61Q19/02 ,  A61Q19/08 ,  A45D44/22

CPC classification number: A61K8/9761 ,  A61Q19/02 ,  A61Q19/08 ,  A45D44/22

Abstract: The present invention provides an agent for preventing and/or improving photoaging and/or dermal pigmentation comprising Thujae Semen extract as an active ingredient. The present invention also provides a cosmetic method which includes a step for applying the agent for preventing and/or improving photoaging and/or dermal pigmentation to skin to be treated, and a cosmetic device to be applied in said method.

公开(公告)号：US20170073751A1

公开(公告)日：2017-03-16

申请号：US15123274

申请日：2015-03-05

Applicant: Shiseido Company, Ltd

Inventor： Yosuke TOJO ,  Masato IINO ,  Chieko MIZUMOTO ,  Yuzo YOSHIDA ,  Yuko MATSUURA ,  Hisashi MORI

IPC: C12Q1/68 ,  A61Q19/00 ,  A61K8/97 ,  A61K8/64 ,  G01N33/50 ,  G01N33/68

CPC classification number: C12Q1/6876 ,  A61K8/645 ,  A61K8/97 ,  A61K36/28 ,  A61K36/899 ,  A61K36/9068 ,  A61K38/011 ,  A61K2800/782 ,  A61Q19/00 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N33/6812 ,  G01N2333/968 ,  G01N2333/99 ,  G01N2800/20 ,  A61K2300/00

Abstract: The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.

Abstract translation: 本发明的目的是开发一种用于筛选具有在体外研究中增加皮肤屏障功能的作用的药物的方法，并评估皮肤中的屏障功能。 可以通过使用丝氨酸消旋酶的活性和/或表达水平作为指标筛选候选药物。

公开(公告)号：US20210189487A1

公开(公告)日：2021-06-24

申请号：US17130886

申请日：2020-12-22

Applicant: Shiseido Company, Ltd

Inventor： Yosuke TOJO ,  Masato IINO ,  Chieko MIZUMOTO ,  Yuzo YOSHIDA ,  Yuko MATSUURA ,  Hisashi MORI

IPC: C12Q1/6876 ,  G01N33/50 ,  A61K38/01 ,  A61K36/9068 ,  A61K36/28 ,  G01N33/68 ,  C12Q1/6883 ,  A61K36/899 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/64 ,  A61Q19/00

Abstract: The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.

公开(公告)号：US20200000704A1

公开(公告)日：2020-01-02

申请号：US16450875

申请日：2019-06-24

Applicant: Shiseido Company, Ltd.

Inventor： Masato IINO ,  Nobuhiko OCHIAI ,  Makoto TSUNENAGA

IPC: A61K8/97 ,  A61Q19/08 ,  A61K8/67

Abstract: The present invention relates to providing a hyaluronidase inhibitor having a good hyaluronidase inhibiting activity. Specifically, the present invention provides with a hyaluronidase inhibitor comprising rosemary extract having a hyaluronidase inhibitory activity, and retinol acetate, which can enhances the hyaluronidase inhibitory activity of rosemary extract.

公开(公告)号：US20190300953A1

公开(公告)日：2019-10-03

申请号：US16412993

申请日：2019-05-15

Applicant: Shiseido Company, Ltd

Inventor： Yosuke TOJO ,  Masato IINO ,  Chieko MIZUMOTO ,  Yuzo YOSHIDA ,  Yuko MATSUURA ,  Hisashi MORI

IPC: C12Q1/6876 ,  A61K36/28 ,  C12Q1/6883 ,  A61K36/899 ,  A61Q19/00 ,  A61K8/97 ,  A61K8/64 ,  G01N33/50 ,  G01N33/68 ,  A61K36/9068 ,  A61K38/01

Abstract: The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.