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公开(公告)号：US20200054966A1
公开(公告)日：2020-02-20
申请号：US16609938
申请日：2018-06-21
Applicant: SHOWA DENKO K.K.
Inventor： Junji SASUGA , Hirobumi AOKI , Yuzuru KOKIDO
Abstract: The present invention relates to a method of separating and analyzing a mixture of oligonucleotides, including performing liquid chromatography using a column packed with a packing material obtained by fixing a diol to a surface of each of porous particles formed of a crosslinked organic polymer. According to this method, the oligonucleotides can be separated and analyzed with higher sensitivity compared to cases where columns having silica gel as a base material are used. In addition, the column can be washed with an alkaline solution.
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公开(公告)号：US20170108474A1
公开(公告)日：2017-04-20
申请号：US15128310
申请日：2015-03-19
Applicant: SHOWA DENKO K.K.
Inventor： Hideyuki KONDO , Junji SASUGA , Takayuki SHUKUYA
CPC classification number: G01N30/52 , B01D15/305 , B01D15/363 , B01D15/3847 , G01N27/62 , G01N30/02 , G01N30/26 , G01N30/56 , G01N30/6052 , G01N30/72 , G01N30/7233 , G01N30/88 , G01N30/96
Abstract: A mass spectrometry method by a liquid chromatograph-mass spectrometer that can detect an organic acid with high sensitivity by retaining, separating and eluting the organic acid without adding any nonvolatile substance to a mobile phase and without receiving any restriction of a ratio of a water-soluble organic solvent, and an analytical column are provided. The mass spectrometry method is a mass spectrometry method for an organic acid by a liquid chromatograph-mass spectrometer, wherein a column packed with a hydrophilic polymer having an anion-exchange group is used, and as a mobile phase, a water-soluble organic solvent-water mixed solution is used. The analytical column is a column for liquid chromatography for an organic acid, in which a polyether ether ketone (PEEK) resin housing for liquid chromatography is packed with a hydrophilic polymer having an anion-exchange group.
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