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公开(公告)号：US09445716B2
公开(公告)日：2016-09-20
申请号：US14828262
申请日：2015-08-17
发明人： Jiang Liu , Zhuo Zhang , Wing Kee Damon Wong , Ngan Meng Tan , Fengshou Yin , Beng Hai Lee , Huiqi Li , Joo Hwee Lim , Carol Cheung , Tin Aung , Tien Yin Wong , Ziyang Liang , Jun Cheng , Baskaran Mani
CPC分类号： A61B3/0025 , A61B3/12 , A61B5/02007 , A61B5/7264 , A61B5/7267 , A61B5/7275 , G06T7/0012 , G06T7/40 , G06T2207/30041
摘要： A non-stereo fundus image is used to obtain a plurality of glaucoma indicators. Additionally, genome data for the subject is used to obtain genetic marker data relating to one or more genes and/or SNPs associated with glaucoma. The glaucoma indicators and genetic marker data are input into an adaptive model operative to generate an output indicative of a risk of glaucoma in the subject. In combination, the genetic indicators and genome data are more informative about the risk of glaucoma than either of the two in isolation. The adaptive model may be a two-stage model, having a first stage in which individual genetic indicators are combined with respective portions of the genome data by first adaptive model modules to form respective first outputs, and a second stage in which the first outputs are combined by a second adaptive mode. Texture analysis is performed on the fundus images to classify them based on their quality, and only images which are determined to meet a quality criterion are subjected to an analysis to determine if they exhibit glaucoma indicators. Also, the images are put into a standard format. The system may include estimating the position of the optic cup by combining results from multiple optic cup segmentation techniques. The system may include estimating the position of the optic disc by applying edge detection to the funds image, excluding edge points that are unlikely to be optic disc boundary points, and estimating the position of an optic disc by fitting an ellipse to the remaining edge points.
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2.发明申请METHODS AND SYSTEMS FOR CHARACTERIZING ANGLE CLOSURE GLAUCOMA FOR RISK ASSESSMENT OR SCREENING 有权用于表征风险评估或筛选的角膜闭合玻璃体的方法和系统公开(公告)号：US20150161785A1
公开(公告)日：2015-06-11
申请号：US14419237
申请日：2013-08-01
发明人： Yanwu Xu , Jiang Liu , Wing Kee Damon Wong , Beng Hai Lee , Tin Aung , Baskaran Mani , Shamira Perera
CPC分类号： G06T7/0012 , A61B3/102 , A61B3/117 , G06K9/46 , G06K2009/4666 , G06T7/73 , G06T2207/10072 , G06T2207/10101 , G06T2207/30041
摘要： A method is proposed for analysing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing the junction.
摘要翻译： 提出了一种用于分析受试者眼睛前段（AS）的光学相干断层扫描（OCT）图像的方法。 定义感兴趣区域，其是包含角膜和虹膜的交界处的图像的区域，以及估计的位置，导出感兴趣区域内的结。 使用该图像获得图像的第二区域，其是包含结点的估计位置的图像的一部分。 获得第二区域的特征，并且将这些特征输入到自适应模型以生成表征结点的数据。
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公开(公告)号：US09684959B2
公开(公告)日：2017-06-20
申请号：US14423704
申请日：2013-08-26
发明人： Jun Cheng , Jiang Liu , Yanwu Xu , Fengshou Yin , Ngan Meng Tan , Wing Kee Damon Wong , Beng Hai Lee , Xiangang Cheng , Xinting Gao , Zhuo Zhang , Tien Yin Wong , Ching-Yu Cheng , Yim-lui Carol Cheung , Baskaran Mani , Tin Aung
CPC分类号： G06T7/0012 , G06K9/0061 , G06K9/00617 , G06K9/4633 , G06K9/6269 , G06K2009/4657 , G06T7/11 , G06T7/187 , G06T7/62 , G06T11/203 , G06T2200/28 , G06T2207/10024 , G06T2207/20016 , G06T2207/30041 , G06T2207/30196 , G06T2210/41
摘要： A method is proposed for automatically locating the optic disc or the optic cup in an image of the rear of an eye. A portion of the image containing the optic disc or optic cup is divided into sub-regions using a clustering algorithm. Biologically inspired features, and optionally other features, are obtained for each of the sub-regions. An adaptive model uses the features to generate data indicative of whether each sub-region is within or outside the optic disc or optic cup. The result is then smoothed, to form an estimate of the position of the optic disc or optic cup.
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4.发明授权Methods and systems for characterizing angle closure glaucoma for risk assessment or screening 有权表征角闭合青光眼进行风险评估或筛查的方法和系统公开(公告)号：US09501823B2
公开(公告)日：2016-11-22
申请号：US14419237
申请日：2013-08-01
发明人： Yanwu Xu , Jiang Liu , Wing Kee Damon Wong , Beng Hai Lee , Tin Aung , Baskaran Mani , Shamira Perera
CPC分类号： G06T7/0012 , A61B3/102 , A61B3/117 , G06K9/46 , G06K2009/4666 , G06T7/73 , G06T2207/10072 , G06T2207/10101 , G06T2207/30041
摘要： A method is proposed for analyzing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing the junction.
摘要翻译： 提出了一种用于分析受试者眼睛前段（AS）的光学相干断层扫描（OCT）图像的方法。 定义感兴趣区域，其是包含角膜和虹膜的交界处的图像的区域，以及估计的位置，导出感兴趣区域内的结。 使用该图像获得图像的第二区域，其是包含结点的估计位置的图像的一部分。 获得第二区域的特征，并且将这些特征输入到自适应模型以生成表征结点的数据。
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5.发明申请METHODS AND SYSTEMS FOR AUTOMATIC LOCATION OF OPTIC STRUCTURES IN AN IMAGE OF AN EYE, AND FOR AUTOMATIC RETINA CUP-TO-DISC RATIO COMPUTATION 有权用于自动定位眼睛图像中的光学结构的方法和系统，以及用于自动立体镜对比度计算公开(公告)号：US20150187070A1
公开(公告)日：2015-07-02
申请号：US14423704
申请日：2013-08-26
发明人： Jun Cheng , Jiang Liu , Yanwu Xu , Fengshou Yin , Ngan Meng Tan , Wing Kee Damon Wong , Beng Hai Lee , Xiangang Cheng , Xinting Gao , Zhuo Zhang , Tien Yin Wong , Ching-Yu Cheng , Yim-lui Carol Cheung , Baskaran Mani , Tin Aung
CPC分类号： G06T7/0012 , G06K9/0061 , G06K9/00617 , G06K9/4633 , G06K9/6269 , G06K2009/4657 , G06T7/11 , G06T7/187 , G06T7/62 , G06T11/203 , G06T2200/28 , G06T2207/10024 , G06T2207/20016 , G06T2207/30041 , G06T2207/30196 , G06T2210/41
摘要： A method is proposed for automatically locating the optic disc or the optic cup in an image of the rear of an eye. A portion of the image containing the optic disc or optic cup is divided into sub-regions using a clustering algorithm. Biologically inspired features, and optionally other features, are obtained for each of the sub-regions. An adaptive model uses the features to generate data indicative of whether each sub-region is within or outside the optic disc or optic cup. The result is then smoothed, to form an estimate of the position of the optic disc or optic cup.
摘要翻译： 提出了一种用于将视盘或视杯自动定位在眼后方的图像中的方法。 使用聚类算法将包含视盘或视杯的图像的一部分划分成子区域。 为每个子区域获得生物启发特征，以及可选的其他特征。 自适应模型使用特征来产生指示每个子区域是否在视盘或视觉杯内或外的数据。 然后将结果平滑，以形成视盘或视杯的位置的估计。
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公开(公告)号：US20150125052A1
公开(公告)日：2015-05-07
申请号：US14406201
申请日：2013-06-05
发明人： Wing Kee Damon Wong , Xiangang Cheng , Jiang Liu , Ngan Meng Tan , Beng Hai Lee , Fengshou Yin , Mayuri Bhargava , Gemmy Cheung , Tien Yin Wong
CPC分类号： G06T7/0012 , G06K9/00597 , G06K9/46 , G06K9/4642 , G06K9/4676 , G06K9/6223 , G06K9/6227 , G06K2009/4666 , G06T7/40 , G06T7/90 , G06T2207/30041
摘要： A method is proposed for automatically analysing a retina image, to identify the presence of drusen which is indicative of age-related macular degeneration. The method proposes dividing a region of interest including the macula centre into patches, obtaining a local descriptor of each of the patches, reducing the dimensionality of the local descriptor by comparing the local descriptor to a tree-like clustering model and obtaining transformed data indicating the identity of the cluster. The transformed data is fed into an adaptive model which generates data indicative of the presence of drusen in the retinal image. Furthermore, the trans formed data can be used to obtain the location of the drusen within the image.
摘要翻译： 提出一种自动分析视网膜图像的方法，以确定指示年龄相关性黄斑变性的玻璃疣的存在。 该方法提出将包括黄斑中心的感兴趣区域划分为斑块，获得每个斑块的局部描述符，通过将本地描述符与树状聚类模型进行比较来获得局部描述符的维度，并获得指示 集群的身份。 将变换的数据馈送到自适应模型，其生成指示视网膜图像中玻璃疣的存在的数据。 此外，反式形成的数据可以用于获得图像中的玻璃疣的位置。
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7.发明授权公开(公告)号：US10325176B2
公开(公告)日：2019-06-18
申请号：US15506708
申请日：2015-08-25
发明人： Fengshou Yin , Wing Kee Damon Wong , Jiang Liu , Beng Hai Lee , Zhuo Zhang , Kavitha Gopalakrishnan , Ying Quan , Ai Ping Yow
摘要： A method of assessing the quality of an retinal image (such as a fundus image) includes selecting at least one region of interest within a retinal image corresponding to a particular structure of the eye (e.g. the optic disc or the macula), and a quality score is calculated in respect of the, or each, region-of-interest. Each region of interest is typically one associated with pathology, as the optic disc and the macula are. Optionally, a quality score may be calculated also in respect of the eye as a whole (i.e. over the entire image, if the entire image corresponds to the retina).
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