公开(公告)号：US20220119878A1

公开(公告)日：2022-04-21

申请号：US17500759

申请日：2021-10-13

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US12123054B2

公开(公告)日：2024-10-22

申请号：US17545226

申请日：2021-12-08

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Abrehet Abdu ,  Timothy Looney

IPC: C12Q1/68 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q1/6869 ,  C12Q2535/122

Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.

公开(公告)号：US20210277461A1

公开(公告)日：2021-09-09

申请号：US17194023

申请日：2021-03-05

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US20240401125A1

公开(公告)日：2024-12-05

申请号：US18807061

申请日：2024-08-16

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Abrehet Abdu ,  Timothy Looney

IPC: C12Q1/6869

Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.

公开(公告)号：US12123055B2

公开(公告)日：2024-10-22

申请号：US17727673

申请日：2022-04-22

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/68 ,  C12Q1/6855 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US20240093293A1

公开(公告)日：2024-03-21

申请号：US18459086

申请日：2023-08-31

Applicant: Singular Genomics Systems, Inc.

Inventor： Timothy Looney ,  Christian Berrios

IPC: C12Q1/6874 ,  C12Q1/6844

CPC classification number: C12Q1/6874 ,  C12Q1/6844

Abstract: Disclosed herein, inter alia, are methods and compositions useful for increasing monoclonal nucleic acid amplification products on a solid support.

公开(公告)号：US20220033895A1

公开(公告)日：2022-02-03

申请号：US17500733

申请日：2021-10-13

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US11225688B2

公开(公告)日：2022-01-18

申请号：US17127308

申请日：2020-12-18

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Abrehet Abdu ,  Timothy Looney

IPC: C12Q1/68 ,  C12Q1/6869

Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.