公开(公告)号：US20220090034A1

公开(公告)日：2022-03-24

申请号：US17395800

申请日：2021-08-06

申请人： Solis BioDyne OÜ

发明人： Olev Kahre ,  Kadri Artma ,  Tiina Kahre

IPC分类号： C12N9/12 ,  C07K14/00 ,  C12N9/14 ,  C12N9/22 ,  C12N9/78 ,  C12N9/96 ,  C12N9/50 ,  C12N9/00

摘要： This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide (e.g., Taq polymerase). Such peptides, polypeptides, fusion polypeptides, or compositions include polypeptides linked to a peptide tag that enhances the stability of the polypeptide. The peptides, polypeptides, fusion polypeptides, compositions may also enhance the activity, specificity, and/or fidelity of other polypeptides in a reaction mixture. The disclosure also provides methods of using such peptides, polypeptides, fusion polypeptides, compositions.

公开(公告)号：US20200172883A1

公开(公告)日：2020-06-04

申请号：US16570157

申请日：2019-09-13

申请人： Solis BioDyne OÜ

发明人： Olev Kahre ,  Kadri Artma ,  Tiina Kahre

IPC分类号： C12N9/12 ,  C12N9/00 ,  C12N9/96 ,  C12N9/78 ,  C12N9/50 ,  C12N9/22 ,  C12N9/14 ,  C07K14/00

摘要： This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide (e.g., Taq polymerase). Such peptides, polypeptides, fusion polypeptides, or compositions include polypeptides linked to a peptide tag that enhances the stability of the polypeptide. The peptides, polypeptides, fusion polypeptides, compositions may also enhance the activity, specificity, and/or fidelity of other polypeptides in a reaction mixture. The disclosure also provides methods of using such peptides, polypeptides, fusion polypeptides, compositions.

公开(公告)号：US11118169B2

公开(公告)日：2021-09-14

申请号：US16570157

申请日：2019-09-13

申请人： Solis BioDyne OÜ

发明人： Olev Kahre ,  Kadri Artma ,  Tiina Kahre

IPC分类号： C12N9/12 ,  C07K14/00 ,  C12N9/00 ,  C12N9/14 ,  C12N9/22 ,  C12N9/78 ,  C12N9/96 ,  C12N9/50

摘要： This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide (e.g., Taq polymerase). Such peptides, polypeptides, fusion polypeptides, or compositions include polypeptides linked to a peptide tag that enhances the stability of the polypeptide. The peptides, polypeptides, fusion polypeptides, compositions may also enhance the activity, specificity, and/or fidelity of other polypeptides in a reaction mixture. The disclosure also provides methods of using such peptides, polypeptides, fusion polypeptides, compositions.

公开(公告)号：US20180245056A1

公开(公告)日：2018-08-30

申请号：US15728344

申请日：2017-10-09

申请人： SOLIS BIODYNE OÜ

发明人： Olev Kahre ,  Kadri Artma ,  Tiina Kahre

IPC分类号： C12N9/12 ,  C12N9/14 ,  C12N9/00 ,  C07K14/00 ,  C12N9/96 ,  C12N9/78 ,  C12N9/50 ,  C12N9/22

CPC分类号： C12N9/1276 ,  C07K14/00 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/50 ,  C12N9/00 ,  C12N9/1252 ,  C12N9/14 ,  C12N9/22 ,  C12N9/50 ,  C12N9/78 ,  C12N9/96 ,  C12Y207/07049

摘要： This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide (e.g., Taq polymerase). Such peptides, polypeptides, fusion polypeptides, or compositions include polypeptides linked to a peptide tag that enhances the stability of the polypeptide. The peptides, polypeptides, fusion polypeptides, compositions may also enhance the activity, specificity, and/or fidelity of other polypeptides in a reaction mixture. The disclosure also provides methods of using such peptides, polypeptides, fusion polypeptides, compositions.

公开(公告)号：US09816078B2

公开(公告)日：2017-11-14

申请号：US15068477

申请日：2016-03-11

申请人： Solis Biodyne OÜ

发明人： Olev Kahre ,  Kadri Artma ,  Tiina Kahre

IPC分类号： C12P21/04 ,  C12N9/12 ,  C07K14/435 ,  C07K14/00 ,  C12N9/22 ,  C12N9/00 ,  C12N9/14 ,  C12N9/50 ,  C12N9/78 ,  C12N9/96

CPC分类号： C12N9/1276 ,  C07K14/00 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/50 ,  C12N9/00 ,  C12N9/1252 ,  C12N9/14 ,  C12N9/22 ,  C12N9/50 ,  C12N9/78 ,  C12N9/96 ,  C12Y207/07049

摘要： This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide (e.g., Taq polymerase). Such peptides, polypeptides, fusion polypeptides, or compositions include polypeptides linked to a peptide tag that enhances the stability of the polypeptide. The peptides, polypeptides, fusion polypeptides, compositions may also enhance the activity, specificity, and/or fidelity of other polypeptides in a reaction mixture. The disclosure also provides methods of using such peptides, polypeptides, fusion polypeptides, compositions.

公开(公告)号：US20160251637A1

公开(公告)日：2016-09-01

申请号：US15068477

申请日：2016-03-11

申请人： Solis Biodyne OÜ

发明人： Olev Kahre ,  Kadri Artma ,  Tiina Kahre

IPC分类号： C12N9/12 ,  C12N9/96

CPC分类号： C12N9/1276 ,  C07K14/00 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/50 ,  C12N9/00 ,  C12N9/1252 ,  C12N9/14 ,  C12N9/22 ,  C12N9/50 ,  C12N9/78 ,  C12N9/96 ,  C12Y207/07049

摘要： This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide (e.g., Taq polymerase). Such peptides, polypeptides, fusion polypeptides, or compositions include polypeptides linked to a peptide tag that enhances the stability of the polypeptide. The peptides, polypeptides, fusion polypeptides, compositions may also enhance the activity, specificity, and/or fidelity of other polypeptides in a reaction mixture. The disclosure also provides methods of using such peptides, polypeptides, fusion polypeptides, compositions.

摘要翻译： 本公开提供了用于增强或增加多肽（例如Taq聚合酶）的稳定性的肽，多肽，融合多肽，组合物和方法。 这样的肽，多肽，融合多肽或组合物包括与增强多肽稳定性的肽标签连接的多肽。 肽，多肽，融合多肽，组合物还可增强其他多肽在反应混合物中的活性，特异性和/或保真度。 本公开还提供了使用这些肽，多肽，融合多肽，组合物的方法。

公开(公告)号：US11987822B2

公开(公告)日：2024-05-21

申请号：US17329358

申请日：2021-05-25

申请人： SOLIS BIODYNE OÜ

发明人： Olev Kahre

IPC分类号： C12N9/12 ,  C12N9/22

CPC分类号： C12N9/1276 ,  C12N9/22 ,  C12Y207/07049 ,  C12Y301/26004 ,  C07K2319/85

摘要： The present disclosure provides non-natural reverse transcriptases for conducting reverse transcription. The non-natural reverse transcriptases herein may have increased thermostability and can conduct reverse transcription more efficiently than natural reverse transcriptases.

公开(公告)号：US11046940B2

公开(公告)日：2021-06-29

申请号：US16092753

申请日：2017-04-12

申请人： SOLIS BIODYNE OÜ

发明人： Olev Kahre

IPC分类号： C12N9/12 ,  C12N9/22

摘要： The present disclosure provides non-natural reverse transcriptases for conducting reverse transcription. The non-natural reverse transcriptases herein may have increased thermostability and can conduct reverse transcription more efficiently than natural reverse transcriptases.