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    Substituted mercapto benzimidazoles
    1.
    发明授权
    Substituted mercapto benzimidazoles 失效
    取代的巯基苯并咪唑

    公开(公告)号：US3927014A

    公开(公告)日：1975-12-16

    申请号：US49264474

    申请日：1974-07-29

    申请人： SQUIBB & SONS INC

    发明人： ROVNYAK GEORGE ,  NARAYANAN VENKATACHALA L ,  HAUGWITZ RUDIGER D ,  CIMARUSTI CHRISTOPHER M

    IPC分类号： C07D263/28 ,  C07D235/28

    CPC分类号： C07D263/28

    摘要： Compounds of the following formula

    WHEREIN Z is ethylene or propylene; R1 is hydrogen, methyl, ethyl, phenyl, nitrophenyl, benzyl, phenethyl, tolyl or xylyl; R2 is alkyl of from 1 to 5 carbons, benzyl, nitrobenzyl, phenethyl, nitrophenethyl, alkoxycarbonylalkylene wherein the alkoxy radical has from 1 to 5 carbons and the alkylene radical has 1 to 3 carbons, dialkylaminoalkylene wherein the dialkyl radicals have from 1 to 3 carbons and the alkylene radical has 2 or 3 carbons, alkanoyl of from 2 to 18 carbons, benzoyl, a substituted benzoyl wherein said substituent is halogen, alkyl of 1 to 3 carbons or phenyl, phenylmethylcarbonyl, phenethylcarbonyl,

    wherein Z and R1 are as defined above,

    WHEREIN ALKYL IS OF 1 TO 5 CARBONS, OR

    R4 is alkyl of 1 to 3 carbons, phenyl, benzyl or phenethyl; X is O or S; R3 is hydrogen, halogen, nitro, amino, cyano, trifluoromethyl, alkyl of from 1 to 3 carbons, alkoxy of from 1 to 3 carbons, dialkylamino wherein each alkyl radical is from 1 to 3 carbons, alkanoyl of from 2 to 6 carbons, or benzoyl; and n is 1 or 2; are disclosed. These compounds exhibit antiinflammatory activity.

    摘要翻译： 下式的化合物WHEREIN Z是乙烯或丙烯; R1是氢，甲基，乙基，苯基，硝基苯基，苄基，苯乙基，甲苯基或二甲苯基; R2是1至5个碳的烷基，苄基，硝基苄基，苯乙基，硝基苯乙基，烷氧基羰基亚烷基，其中烷氧基具有1至5个碳，亚烷基具有1至3个碳，二烷基氨基亚烷基，其中二烷基具有1至3个碳 并且亚烷基具有2或3个碳，2至18个碳的烷酰基，苯甲酰基，其中所述取代基为卤素的取代的苯甲酰基，1至3个碳原子的烷基或苯基，苯基甲基羰基，苯乙基羰基，| ANGLE NS ANGLE Z | R1其中 Z和R 1如上所定义，X并原-C-N-烷基，其中1到5个碳原子的烷基，或者是OR-OR-OR-R4; R4是1至3个碳的烷基，苯基，苄基或苯乙基; X是O或S; R3是氢，卤素，硝基，氨基，氰基，三氟甲基，1至3个碳的烷基，1至3个碳的烷氧基，其中每个烷基是1至3个碳的二烷基氨基，2至6个碳的烷酰基， 或苯甲酰基; n为1或2; 被披露。 这些化合物表现出抗炎活性。

    Certain tetrahydronaphthalenes used in the treatment of cardiac arrhythmia
    2.
    发明授权
    Certain tetrahydronaphthalenes used in the treatment of cardiac arrhythmia 失效
    某些四氢萘用于治疗心律失常

    公开(公告)号：US3930022A

    公开(公告)日：1975-12-30

    申请号：US48108974

    申请日：1974-06-20

    申请人： SQUIBB & SONS INC

    发明人： HAUCK FREDERIC PETER ,  CIMARUSTI CHRISTOPHER M ,  SUNDEEN JOSEPH E

    IPC分类号： C07D331/02 ,  A61K31/135

    CPC分类号： C07D331/02 ,  C07C2602/08

    摘要： AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, ARE USEFUL AS BETA-ADRENERGIC RECEPTOR BLOCKING AGENTS IN THE TREATMENT OF CARDIAC ARRHYTHMIA. In the above formula R1 can be alkyl or arylalkyl and R2 and R3 can each be hydrogen, hydroxyl, alkoxy, or arylalkoxy. Those compounds wherein R1 is arylalkyl and at least one of R2 and R3 is other than hydrogen are novel, and constitute a part of this invention.

    Tetrahydronaphthalenes having the structure

    摘要翻译： 具有结构和其药学上可接受的盐的四氢萘在治疗心脏病的过程中作为亚硝酸受体阻断剂有用。 在上式中，R 1可以是烷基或芳基烷基，R 2和R 3各自可以是氢，羟基，烷氧基或芳基烷氧基。 其中R 1为芳基烷基且R 2和R 3中的至少一个为氢的那些化合物是新颖的，构成本发明的一部分。

    Substituted benzimidazolinethiones
    3.
    发明授权
    Substituted benzimidazolinethiones 失效
    取代的苯并咪唑啉硫代乙酸盐

    公开(公告)号：US3926982A

    公开(公告)日：1975-12-16

    申请号：US48541974

    申请日：1974-07-03

    申请人： SQUIBB & SONS INC

    发明人： ROVNYAK GEORGE ,  NARAYANAN VENKATACHALA L ,  HAUGHWITZ RUDIGER D ,  CIMARUSTI CHRISTOPHER M

    IPC分类号： C07D417/04 ,  C07D235/28

    CPC分类号： C07D417/04

    摘要： Compounds of the following formula

    WHEREIN Z is ethylene or propylene; R1 is hydrogen, methyl, ethyl, phenyl, nitrophenyl, benzyl, phenethyl, tolyl or xylyl; R2 is hydrogen, alkyl of from 1 to 5 carbons, benzyl, nitrobenzyl, phenethyl, nitrophenethyl, alkoxycarbonylalkylene wherein the alkoxy radical has from 1 to 5 carbons and the alkylene radical has 1 to 3 carbons, dialkylaminoalkylene wherein the dialkyl radicals have from 1 to 3 carbons and the alkylene radical has 2 or 3 carbons, alkanoyl of from 2 to 18 carbons, benzoyl, a substituted benzoyl wherein said substituent is halogen, alkyl of 1 to 3 carbons or phenyl,

    wherein Z and R1 are as defined above,

    or

    R4 is alkyl of 1 to 3 carbons, phenyl, benzyl or phenethyl; X is O or S; R3 is hydrogen, halogen, nitro, amino, cyano, trifluoromethyl, alkyl of from 1 to 3 carbons, alkoxy of from 1 to 3 carbons, dialkylamino wherein each alkyl radical is from 1 to 3 carbons, alkanoyl of from 2 to 6 carbons, or benzoyl; and n is 1 or 2; are disclosed. These compounds exhibit antiinflammatory activity.

    摘要翻译： 下式的化合物WHEREIN Z是乙烯或丙烯; R1是氢，甲基，乙基，苯基，硝基苯基，苄基，苯乙基，甲苯基或二甲苯基; R2是氢，1至5个碳的烷基，苄基，硝基苄基，苯乙基，硝基苯乙基，烷氧基羰基亚烷基，其中烷氧基具有1至5个碳，亚烷基具有1至3个碳，二烷基氨基亚烷基，其中二烷基具有1至 3个碳和亚烷基具有2或3个碳，2至18个碳的烷酰基，苯甲酰基，其中所述取代基为卤素的取代苯甲酰基，1至3个碳原子的烷基或苯基，NS Z | R1其中Z和R1为 O分子-CO-R4或X并行-C-NH-R4; R4是1至3个碳的烷基，苯基，苄基或苯乙基; X是O或S; R3是氢，卤素，硝基，氨基，氰基，三氟甲基，1至3个碳的烷基，1至3个碳的烷氧基，其中每个烷基是1至3个碳的二烷基氨基，2至6个碳的烷酰基， 或苯甲酰基; n为1或2; 被披露。 这些化合物表现出抗炎活性。

    Thio-{62 -lactam penicillins
    4.
    发明授权
    Thio-{62 -lactam penicillins 失效
    Thio- {62-内酰胺青霉素

    公开(公告)号：US4010175A

    公开(公告)日：1977-03-01

    申请号：US67377776

    申请日：1976-04-05

    申请人： SQUIBB & SONS INC

    发明人： CIMARUSTI CHRISTOPHER M ,  WOJTKOWSKI PAUL ,  DOLFINI JOSEPH E

    IPC分类号： C07D499/00 ,  C07D499/42

    CPC分类号： C07D499/00

    摘要： Thio- beta -lactam penicillins of the general formula wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R1 is hydrogen, lower alkyl, cycloalkyl, phenyl, lower alkoxyphenyl, phenoxy, phenyl-lower alkyl or certain heterocyclic groups; R2 is hydrogen, amino, carboxy or ureido; and n is 0 or 1; are useful as antimicrobial agents.

    摘要翻译： 其中R为氢，低级烷基，苯基 - 低级烷基，三卤代乙基，碱金属或碱土金属的通式为“IMAGE”的硫代β-内酰胺青霉素; R 1是氢，低级烷基，环烷基，苯基，低级烷氧基苯基，苯氧基，苯基 - 低级烷基或某些杂环基; R2是氢，氨基，羧基或脲基; 并且n为0或1; 作为抗微生物剂是有用的。