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公开(公告)号：US20210275806A1
公开(公告)日：2021-09-09
申请号：US17227924
申请日：2021-04-12
Inventor： Saurav Paul , Troy T. Tegg , Israel A, Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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公开(公告)号：US20140194867A1
公开(公告)日：2014-07-10
申请号：US14087991
申请日：2013-11-22
Inventor： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Harry A. Puryear , Saurav Paul
CPC classification number: A61B18/1492 , A61B5/0084 , A61B5/01 , A61B5/0402 , A61B5/042 , A61B5/0538 , A61B5/1076 , A61B5/1079 , A61B5/4836 , A61B5/742 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00351 , A61B2018/00714 , A61B2018/00738 , A61B2018/00779 , A61B2018/00875 , A61B2018/0212 , A61B2034/301 , A61B2090/065 , A61B2218/002
Abstract: A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU) configured to acquire magnitudes for a component of a complex impedance between an electrode and tissue, and the power applied to the tissue during lesion formation. The ECU is configured to calculate a value responsive to the complex impedance component and the power. The value is indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, or a predicted tissue temperature. The method includes acquiring magnitudes for a component of a complex impedance between an electrode and tissue and the power applied during lesion formation. The method includes calculating a value responsive to the complex impedance component and the power, the value being indicative of a predicted lesion depth, a likelihood the lesion has reached a predetermined depth, and/or a predicted tissue temperature.
Abstract translation: 提供了一种用于评估组织中病变形成的方法和系统。 该系统包括电子控制单元（ECU），其被配置为获取电极和组织之间的复阻抗的分量的大小以及在损伤形成期间施加到组织的功率。 ECU被配置为计算响应于复阻抗分量和功率的值。 该值表示预测的病变深度，病变达到预定深度的可能性，或预测的组织温度。 该方法包括获取电极和组织之间的复阻抗的分量的大小以及在损伤形成期间施加的功率。 该方法包括计算响应于复阻抗分量和功率的值，该值指示预测的病变深度，病变达到预定深度的可能性和/或预测的组织温度。
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公开(公告)号：US20240342469A1
公开(公告)日：2024-10-17
申请号：US18754711
申请日：2024-06-26
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
CPC classification number: A61N1/327 , A61B18/14 , A61B2018/0016
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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公开(公告)号：US11000684B2
公开(公告)日：2021-05-11
申请号：US15931240
申请日：2020-05-13
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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5.发明授权公开(公告)号：US09549777B2
公开(公告)日：2017-01-24
申请号：US14821054
申请日：2015-08-07
Inventor： Huisun Wang , Jeremy D. Dando , Harry A. Puryear
CPC classification number: A61B18/1492 , A61B2018/00577 , A61B2018/00791 , A61B2034/2051 , A61B2218/002
Abstract: Embodiments of the present invention provide an irrigated catheter having irrigation fluid directed at target areas where coagulation is more likely to occur so as to minimize blood coagulation and the associated problems. In one embodiment, an irrigated ablation electrode assembly for use with an irrigated catheter device comprises a proximal member having at least one passageway for a fluid with an outlet disposed at an external surface of the proximal member; and a distal member connected with the proximal member and having an external surface. The distal member includes an electrode. The external surface of the proximal member and the external surface of the distal member meet at an intersection. The at least one passageway of the proximal member is configured to direct a fluid flow through the outlet toward a region adjacent the intersection.
Abstract translation: 本发明的实施方案提供了一种具有冲洗流体的灌溉导管，该冲洗流体被引导到更可能发生凝结的目标区域，从而使血液凝固和相关问题最小化。 在一个实施例中，一种与灌溉导管装置一起使用的灌溉消融电极组件包括近端构件，其具有用于流体的至少一个通道，其中出口设置在近端构件的外表面处; 以及与所述近端构件连接并具有外表面的远侧构件。 远侧构件包括电极。 近端构件的外表面和远端构件的外表面在相交处相交。 近端构件的至少一个通道构造成将流体流动引导通过邻近交叉点的区域。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20160030110A1
公开(公告)日：2016-02-04
申请号：US14821054
申请日：2015-08-07
Inventor： Huisun S. Wang , Jeremy D. Dando , Harry A. Puryear
IPC: A61B18/14
CPC classification number: A61B18/1492 , A61B2018/00577 , A61B2018/00791 , A61B2034/2051 , A61B2218/002
Abstract: Embodiments of the present invention provide an irrigated catheter having irrigation fluid directed at target areas where coagulation is more likely to occur so as to minimize blood coagulation and the associated problems. In one embodiment, an irrigated ablation electrode assembly for use with an irrigated catheter device comprises a proximal member having at least one passageway for a fluid with an outlet disposed at an external surface of the proximal member; and a distal member connected with the proximal member and having an external surface. The distal member includes an electrode. The external surface of the proximal member and the external surface of the distal member meet at an intersection. The at least one passageway of the proximal member is configured to direct a fluid flow through the outlet toward a region adjacent the intersection.
Abstract translation: 本发明的实施方案提供了一种具有冲洗流体的灌溉导管，该冲洗流体被引导到更可能发生凝结的目标区域，从而使血液凝固和相关问题最小化。 在一个实施例中，一种与灌溉导管装置一起使用的灌溉消融电极组件包括近端构件，其具有用于流体的至少一个通道，其中出口设置在近端构件的外表面处; 以及与所述近端构件连接并具有外表面的远侧构件。 远侧构件包括电极。 近端构件的外表面和远端构件的外表面在相交处相交。 近端构件的至少一个通道构造成将流体流动引导通过邻近交叉点的区域。
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公开(公告)号：US10688300B2
公开(公告)日：2020-06-23
申请号：US15064664
申请日：2016-03-09
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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公开(公告)号：US20240390671A1
公开(公告)日：2024-11-28
申请号：US18795674
申请日：2024-08-06
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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公开(公告)号：US11331136B2
公开(公告)日：2022-05-17
申请号：US15589652
申请日：2017-05-08
Inventor： Saurav Paul , Troy T. Tegg , Chou Thao , Harry A. Puryear
Abstract: An electrode for use on a medical device is disclosed. The electrode may have a main body of electrically conductive material extending along an axis and may have a proximal end and a distal end. The electrode may also include a magnetic resonance imaging (MRI) tracking coil disposed in the body. The MRI tracking coil may comprise electrically insulated wire. A catheter including an electrode, as well as a method for determining the location of an electrode, are also disclosed.
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公开(公告)号：US20200269038A1
公开(公告)日：2020-08-27
申请号：US15931240
申请日：2020-05-13
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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