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公开(公告)号：US20160324728A1
公开(公告)日：2016-11-10
申请号：US15111847
申请日：2015-01-19
Applicant: STRAUMANN HOLDING AG
Inventor： Alessandra Apicella , Peggy Heunemann
IPC: A61K6/00 , A61K38/17 , A61K47/48 , A61K47/18 , A61Q11/00 , A61K8/64 , A61K8/73 , A61K8/36 , A61K8/44 , A61K35/32 , A61K6/027
CPC classification number: A61K6/0038 , A61K6/0041 , A61K6/0047 , A61K6/0067 , A61K6/027 , A61K8/36 , A61K8/44 , A61K8/64 , A61K8/733 , A61K8/735 , A61K35/32 , A61K38/17 , A61K47/183 , A61K47/61 , A61K2800/52 , A61K2800/591 , A61K2800/60 , A61K2800/805 , A61K2800/84 , A61Q11/00
Abstract: The present invention relates to a process for producing a pharmaceutical, dental and/or cosmetic formulation comprising purified enamel matrix proteins and/or enamel matrix derivative (EMD) proteins, which is heat stable. In particular, the present invention is related to a process for producing stable formulations of enamel matrix proteins and/or enamel matrix derivative (EMD) proteins, wherein said proteins and/or derivatives are solved in a low pH formulation before being subjected to a heat-treatment step.
Abstract translation: 本发明涉及一种制备药物，牙科和/或化妆品制剂的方法，其包含热稳定的纯化的釉质基质蛋白质和/或釉质基质衍生物（EMD）蛋白质。 特别地，本发明涉及一种用于生产釉质基质蛋白质和/或釉质基质衍生物（EMD）蛋白质的稳定制剂的方法，其中所述蛋白质和/或衍生物在经受热量之前溶解在低pH制剂中 处理步骤。
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公开(公告)号：US20180169303A1
公开(公告)日：2018-06-21
申请号：US15323283
申请日：2015-07-09
Applicant: STRAUMANN HOLDING AG
Inventor： Alessandra Apicella , Peggy Heunemann
CPC classification number: A61L27/54 , A61K38/39 , A61K47/12 , A61L27/56 , A61L2400/12 , A61L2430/12
Abstract: The present invention discloses a low viscosity composition comprising enamel matrix derivative (EMD) proteins in a suitable pharmaceutical carrier, said composition having a pH between pH 3.8-4.2, and a viscosity of less than 50 mPa s at 22° C., which, when applied to a porous bone graft material, improves and/or enhances bioactivity and osteoconduction of said bone graft material. The present invention consequently discloses a bone graft material which has been bioactivated using a low viscosity composition comprising enamel matrix derivative (EMD) proteins and which displays enhanced biocompatibility and improved bone regeneration after implantation.
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公开(公告)号：US10525167B2
公开(公告)日：2020-01-07
申请号：US15323283
申请日：2015-07-09
Applicant: STRAUMANN HOLDING AG
Inventor： Alessandra Apicella , Peggy Heunemann
Abstract: The present invention discloses a low viscosity composition comprising enamel matrix derivative (EMD) proteins in a suitable pharmaceutical carrier, said composition having a pH between pH 3.8-4.2, and a viscosity of less than 50 mPa s at 22° C., which, when applied to a porous bone graft material, improves and/or enhances bioactivity and osteoconduction of said bone graft material. The present invention consequently discloses a bone graft material which has been bioactivated using a low viscosity composition comprising enamel matrix derivative (EMD) proteins and which displays enhanced biocompatibility and improved bone regeneration after implantation.
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