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公开(公告)号：US06254598B1
公开(公告)日：2001-07-03
申请号：US09235060
申请日：1999-01-20
申请人： Stuart D Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
发明人： Stuart D Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1477 , A61B17/32 , A61B18/1206 , A61B18/148 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/22061 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1425 , A61B2018/1467 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782 , A61B2218/002 , A61M3/0279 , A61M16/0438 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40
摘要： A sphincter treatment apparatus includes an elongated member having at least one lumen including an inflation lumen and a basket assembly with first and second arms. The basket assembly is coupled to the elongated member and has deployed and non-deployed configurations. An inflatable member is coupled to the elongated member and positioned in an interior of the basket assembly. The inflatable member has deployed and non-deployed states and is coupled to the inflation lumen. In the deployed state, the inflatable member expands the basket assembly to its deployed configuration. A first energy delivery device is positionable in the first arm and advanceable from the first arm to a selected treatment site. A second energy delivery device is positionable in the second arm and advanceable from the second arm to a selected treatment site.
摘要翻译： 括约肌治疗装置包括细长构件，其具有包括充气腔的至少一个内腔和具有第一和第二臂的篮组件。 筐组件联接到细长构件并且具有展开和非展开构造。 可膨胀构件联接到细长构件并且定位在篮组件的内部。 充气构件具有展开状态和非展开状态，并且连接到膨胀腔。 在展开状态下，可膨胀构件将篮组件膨胀到其展开构型。 第一能量输送装置可定位在第一臂中并且可从第一臂推进到选定的处理部位。 第二能量输送装置可定位在第二臂中并且可从第二臂推进到选定的治疗部位。
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公开(公告)号：US08454595B2
公开(公告)日：2013-06-04
申请号：US12653018
申请日：2009-12-07
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00011 , A61B2018/00029 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782
摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.
摘要翻译： 括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。 引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。 能量输送装置联接到引入构件。 保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。
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公开(公告)号：US20120197251A1
公开(公告)日：2012-08-02
申请号：US13443503
申请日：2012-04-10
申请人： STUART D. EDWARDS , David S. Utley , Ronald G. Lax
发明人： STUART D. EDWARDS , David S. Utley , Ronald G. Lax
IPC分类号： A61B18/12
CPC分类号： A61B5/04884 , A61B18/1477 , A61B18/1485 , A61B90/39 , A61B2018/00553 , A61B2018/00738 , A61B2018/046 , A61B2090/3925 , A61B2560/0242
摘要： An apparatus to treat a sphincter has a support member. A sphincter electropotential mapping device includes a mapping electrode. The sphincter electropotential mapping device is coupled to the support member and configured to detect aberrant myoelectric activity of the sphincter.
摘要翻译： 治疗括约肌的装置具有支撑构件。 括约肌电位映射装置包括映射电极。 括约肌电位映射设备耦合到支撑构件并且被配置为检测括约肌的异常肌电活动。
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公开(公告)号：US20100087809A1
公开(公告)日：2010-04-08
申请号：US12653018
申请日：2009-12-07
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00011 , A61B2018/00029 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782
摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.
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5.发明申请Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 有权通过检测和消融胃食管神经和受体来治疗胃反流的方法公开(公告)号：US20100004648A1
公开(公告)日：2010-01-07
申请号：US12584509
申请日：2009-09-08
CPC分类号： A61B18/1233 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00039 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00142 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00553 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00738 , A61B2018/00791 , A61B2018/00821 , A61B2018/00839 , A61B2018/00875 , A61B2018/00898 , A61B2018/0091 , A61B2018/00982 , A61B2018/0237 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2090/064 , A61B2090/3782 , A61B2218/002 , A61N1/06
摘要： A method of treating a sphincter provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity. A method of treating a sphincter provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity.
摘要翻译： 治疗括约肌的方法提供具有映射电极或治疗电极中的至少一个的括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 检测到引起松弛括约肌的生物电活性，并从映射电极或治疗电极传递能量以处理生物电活性。 治疗括约肌的方法提供具有映射电极或治疗电极中的至少一个的括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 检测到引起松弛括约肌的生物电活性，并从映射电极或治疗电极传递能量以处理生物电活性。
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公开(公告)号：US07507234B2
公开(公告)日：2009-03-24
申请号：US11420714
申请日：2006-05-26
申请人： David S. Utley , John Gaiser , Stuart D. Edwards , Scott H. West , Jay Qin
发明人： David S. Utley , John Gaiser , Stuart D. Edwards , Scott H. West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting an operative element into an alimentary canal such that the proximate to a portion of the alimentary canal having tissue to be ablated; and (ii) using the operative element to apply cryogenic ablation to a site of abnormal tissue.
摘要翻译： 提供了在消化道中获取和消融异常上皮组织的方法。 所述方法可以包括以下步骤：（i）将操作元件插入消化道，使得靠近消化道的一部分具有要消融的组织; 和（ii）使用手术元件将低温消融应用于异常组织的部位。
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公开(公告)号：US20130317497A1
公开(公告)日：2013-11-28
申请号：US13958542
申请日：2013-08-03
申请人： Stuart D. Edwards , David S. Utley
发明人： Stuart D. Edwards , David S. Utley
IPC分类号： A61B18/14
CPC分类号： A61B18/1485 , A61B18/00 , A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00867 , A61B2017/22062 , A61B2017/22072 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00107 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00738 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1425 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/3966 , A61B2218/002 , A61F7/12 , A61M3/0279 , A61M16/0454 , A61M16/0459 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40 , A61N7/02 , C08L2201/12
摘要： An apparatus includes an expandable member. The expandable member is sized to be positionable in a sphincter. An energy delivery device is positioned on a surface of the expandable member. The energy delivery device has a configuration that provides sufficient energy delivery to create lesions in the interior of the sphincter. When the expandable member is removed from the sphincter, the sphincter returns to its closed or contracted configuration.
摘要翻译： 一种装置包括可扩张构件。 可扩张构件的大小可定位在括约肌中。 能量输送装置位于可膨胀构件的表面上。 能量输送装置具有提供足够的能量输送以在括约肌内部产生损伤的构造。 当可伸缩构件从括约肌中取出时，括约肌返回到其闭合或收缩的构型。
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8.发明授权Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 失效通过检测和消融胃食管神经和受体来治疗胃反流的方法公开(公告)号：US06405732B1
公开(公告)日：2002-06-18
申请号：US09410448
申请日：1999-10-01
申请人： Stuart D. Edwards , John Gaiser , David S. Utley
发明人： Stuart D. Edwards , John Gaiser , David S. Utley
IPC分类号： A61B1900
CPC分类号： A61B18/1233 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00039 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00142 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00553 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00738 , A61B2018/00791 , A61B2018/00821 , A61B2018/00839 , A61B2018/00875 , A61B2018/00898 , A61B2018/0091 , A61B2018/00982 , A61B2018/0237 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2090/064 , A61B2090/3782 , A61B2218/002 , A61N1/06
摘要： A method of treating a sphincter provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity.
摘要翻译： 治疗括约肌的方法提供具有映射电极或治疗电极中的至少一个的括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 检测到引起松弛括约肌的生物电活性，并从映射电极或治疗电极传递能量以处理生物电活性。
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公开(公告)号：US20140005660A1
公开(公告)日：2014-01-02
申请号：US14015993
申请日：2013-08-30
申请人： Stuart D. Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
发明人： Stuart D. Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/22061 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00488 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00648 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1405 , A61B2018/1467 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782 , A61B2217/007 , A61B2218/002 , A61M3/0279 , A61M16/0438 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40
摘要： An apparatus treats tissue at or near a sphincter. The apparatus has an elongated member having at least one lumen including an inflation lumen, and a basket assembly including a first and a second arm. An inflatable member is coupled to the inflation lumen and has a deployed and a non-deployed state. In the deployed state, the inflatable member expands the basket assembly into contact with tissue. At least one of the first and second arms of the basket assembly has a fluid lumen having an aperture for conveying a fluid from the basket assembly. A source of fluid is coupled to the fluid lumen for conveyance of fluid through the aperture. The fluid can be, e.g., an electrolytic solution, and/or an anti-infection agent, and/or an echogenic media, and/or a steroid, and/or an anesthetic, and/or a medicament, and/or a tissue cooling agent. The source can be a drug delivery device.
摘要翻译： 装置处理括约肌处或附近的组织。 该装置具有细长构件，其具有包括充气腔的至少一个腔，以及包括第一臂和第二臂的篮组件。 可膨胀构件联接到膨胀腔并具有展开和非展开状态。 在展开状态下，可膨胀构件将篮组件膨胀成与组织接触。 篮组件的第一和第二臂中的至少一个具有流体腔，其具有用于从篮组件输送流体的孔。 流体源耦合到流体腔，用于输送流体通过该孔。 流体可以是例如电解溶液和/或抗感染剂和/或回声介质，和/或类固醇，和/或麻醉剂，和/或药物，和/或组织 冷却剂。 来源可以是药物递送装置。
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公开(公告)号：US20130253509A1
公开(公告)日：2013-09-26
申请号：US13902830
申请日：2013-05-26
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00011 , A61B2018/00029 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782
摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.
摘要翻译： 括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。 引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。 能量输送装置联接到引入构件。 保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。
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