公开(公告)号：US20170158682A1

公开(公告)日：2017-06-08

申请号：US15320907

申请日：2015-05-28

Applicant: Sumitomo Chemical Company, Limited

Inventor： Takashi MIYAMOTO ,  Daisuke SASAYAMA

IPC: C07D413/04 ,  C07D213/81 ,  C07D213/78

CPC classification number: C07D413/04 ,  B29C45/2806 ,  B29C45/281 ,  C07D213/62 ,  C07D213/78 ,  C07D213/81

Abstract: A compound represented by formula (4) is produced by a step A of reacting a compound represented by formula (2): wherein R1 represents an ethyl group or the like, R represents a halogen atom or the like, n represents 0, 1, 2, or 3, and M represents potassium or the like, with thionyl chloride to obtain a compound represented by formula (1): a step B of reacting the compound represented by formula (1) with a compound represented by formula (5): wherein A1 represents a nitrogen atom or ═CH—, R5 represents a trifluoromethyl group or the like, and m represents 1 or 2, to produce a compound represented by formula (3): or an acid salt thereof; and a step C of reacting the compound represented by formula (3) or an acid salt thereof in the presence of acid at 100° C. to 180° C. to obtain the compound represented by formula (4):

公开(公告)号：US20180368407A1

公开(公告)日：2018-12-27

申请号：US16062392

申请日：2016-12-12

Applicant: Sumitomo Chemical Company, Limited

Inventor： Takashi MIYAMOTO ,  Kosuke TAKEBAYASHI

IPC: A01N43/76 ,  C07D413/04 ,  G01N23/20

CPC classification number: A01N43/76 ,  A01N47/02 ,  C07B2200/13 ,  C07D413/04 ,  G01N23/20075

Abstract: A type 2 crystal of 2-(3-ethanesulfonylpyridin-2-yl)-5-(trifluoromethanesulfonyl)benzoxazole having diffraction peaks at 2θ=14.0±0.2°, 14.3±0.2°, 16.5±0.2°, 16.9±0.2°, 17.6±0.2°, 18.8±0.2°, 19.9±0.2°, and 22.3±0.2° in powder X-ray diffraction using Cu-Kα radiation is a stable crystal.

公开(公告)号：US20160090363A1

公开(公告)日：2016-03-31

申请号：US14892266

申请日：2014-04-24

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Yasuyuki NAKAE ,  Takayuki WAKAMATSU ,  Takashi MIYAMOTO

IPC: C07D237/12 ,  C07D237/18 ,  C07D237/14

CPC classification number: C07D237/12 ,  C07D237/14 ,  C07D237/18

Abstract: A pyridazine compound represented by formula [1]: which is useful as an active ingredient of a plant disease control agent can be produced, by steps of obtaining a compound represented by formula [3]: by reacting a compound represented by formula [4]: with a compound represented by formula [5]: obtaining a compound represented by formula [2]: by deprotecting the compound [3]; and reacting the compound [2] with a chlorinating agent.

Abstract translation: 由式[1]表示的哒嗪化合物可用作植物病害调节剂的活性成分，可通过以下步骤制备：通过以下步骤制备式[3]表示的化合物：通式[4]表示的化合物， ：用式[5]表示的化合物：得到式[2]表示的化合物：通过使化合物[3]脱保护; 并使化合物[2]与氯化剂反应。

公开(公告)号：US20150376138A1

公开(公告)日：2015-12-31

申请号：US14767533

申请日：2014-02-18

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Yasuyuki NAKAE ,  Akio MANABE ,  Takashi MIYAMOTO

IPC: C07D237/14 ,  C07C67/475 ,  C07C69/675 ,  C07D237/08

CPC classification number: C07D237/14 ,  C07C67/475 ,  C07C69/675 ,  C07D237/08

Abstract: The present invention provides a process for producing a compound of the formula (1) wherein X represents a hydrogen atom, etc., and Y represents a hydrogen atom, etc., which comprises step 1 of reacting a compound of the formula (2) and a compound of the formula (3) in the presence of a Lewis acid wherein R represents a hydrogen atom, etc., to obtain an adduct, and step 2 of reacting the adduct obtained in the step 1 and hydrazine to obtain the compound of the formula (1).

Abstract translation: 本发明提供了制备式（1）化合物的方法，其中X表示氢原子等，Y表示氢原子等，其包括使式（2）的化合物与式 和式（3）的化合物在路易斯酸存在下，其中R表示氢原子等，得到加合物，步骤2使步骤1中得到的加合物与肼反应，得到化合物 公式（1）。

公开(公告)号：US20170008853A1

公开(公告)日：2017-01-12

申请号：US15113494

申请日：2015-02-16

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Yasuyuki NAKAE ,  Takashi MIYAMOTO

IPC: C07D231/22

CPC classification number: C07D231/22 ,  C07D231/20

Abstract: A method for producing a pyrazole compound represented by formula (1): (wherein R1 represents an optionally substituted C1-12 alkyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C6-16 aryl group, or an optionally substituted pyridyl group, R2 and R3 each independently represent a hydrogen atom, a halogen atom, a C1-3 alkyl group, or a C1-3 haloalkyl group), said method including a step in which a pyrazolidine compound represented by formula (2): (wherein R1, R2, and R3 are as defined above) is reacted with a nitrite in the presence of an acid, allows a pyrazole compound to be produced industrially.

Abstract translation: 一种制备由式（1）表示的吡唑化合物的方法：（其中R 1表示任选取代的C 1-12烷基，任选取代的C 3-12环烷基，任选取代的C 6-16芳基或 任选取代的吡啶基，R 2和R 3各自独立地表示氢原子，卤素原子，C 1-3烷基或C 1-3卤代烷基），所述方法包括以下步骤：其中吡唑烷化合物 由式（2）表示：（其中R 1，R 2和R 3如上定义）在酸存在下与亚硝酸酯反应，可以在工业上制备吡唑化合物。

公开(公告)号：US20180354894A1

公开(公告)日：2018-12-13

申请号：US16062275

申请日：2016-12-14

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Takashi MIYAMOTO ,  Yuta NAGASHIMA ,  Masaji HIROTA

IPC: C07C263/10 ,  C07C265/12

CPC classification number: C07C263/10 ,  C07C265/12

Abstract: The present invention provides a process for producing an isocyanate compound such as 3-methyl-2-methoxymethyl-1-isocyanate benzene and the like. By reacting 3-Methyl-2-methoxymethyl aniline and the like with phosgene in the presence of a tertiary amine at 10° C. to 14° C. in one or more solvents selected from the group consisting of toluene and xylene, isocyanate compounds such as 3-methyl-2-methoxymethyl-1-isocyanate benzene and the like can be produced at high yield.