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公开(公告)号：US20140121282A1
公开(公告)日：2014-05-01
申请号：US14149492
申请日：2014-01-07
发明人： Liming SHAO , Fengjiang WANG , Scott Christopher MALCOLM , Michael Charles HEWITT , Jianguo MA , Seth RIBE , Mark A. VARNEY , Una CAMPBELL , Sharon Rae ENGEL , Larry Wendell HARDY , Patrick KOCH , Rudy SCHREIBER , Kerry L. SPEAR
IPC分类号： C07C215/42 , C07C217/76
CPC分类号： C07C215/42 , A61K31/135 , A61P25/24 , A61P25/28 , C07B2200/07 , C07C217/52 , C07C217/76 , C07C2601/14
摘要： Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
摘要翻译： 公开了苯基取代的环己胺衍生物及其合成和表征的方法。 本文阐述了这些化合物治疗/预防神经系统疾病及其合成方法的用途。 本发明的示例性化合物抑制内源性一元胺如多巴胺，5-羟色胺和去甲肾上腺素的再摄取（例如，从突触腭裂）并调节一种或多种单胺转运蛋白。 还提供了掺入本发明化合物的药物制剂。
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公开(公告)号：US20170204050A1
公开(公告)日：2017-07-20
申请号：US15418986
申请日：2017-01-30
发明人： Liming SHAO , Fengjiang WANG , Scott Christopher MALCOLM , Michael Charles HEWITT , Jianguo MA , Seth RIBE , Mark A. VARNEY , Una CAMPBELL , Sharon Rae ENGEL , Larry Wendell HARDY , Patrick KOCH , Rudy SCHREIBER , Kerry L. Spear
IPC分类号： C07C215/42 , C07C217/76
CPC分类号： C07C215/42 , A61K31/135 , A61P25/24 , A61P25/28 , C07B2200/07 , C07C217/52 , C07C217/76 , C07C2601/14
摘要： Phenyl-substituted cyclohexylamine derivatives and methods for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
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公开(公告)号：US20150126511A1
公开(公告)日：2015-05-07
申请号：US14502532
申请日：2014-09-30
发明人： Liming SHAO , Fengjiang WANG , Scott Christopher MALCOLM , Michael Charles HEWITT , Larry R. BUSH , Jianguo MA , Mark A. VARNEY , Una CAMPBELL , Sharon Rae ENGEL , Larry Wendell HARDY , Patrick KOCH , John E. CAMPBELL
IPC分类号： C07D333/20 , C07D211/16 , C07D277/28 , C07C211/17 , C07D307/52
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要翻译： 本发明涉及新的环己胺衍生物及其在治疗和/或预防中枢神经系统（CNS）障碍如抑郁，焦虑，精神分裂症和睡眠障碍中的用途及其合成方法。 本发明还涉及含有本发明化合物的药物组合物，以及抑制内源性单胺如从突触间隙中再摄取多巴胺，5-羟色胺和去甲肾上腺素以及调节一种或多种单胺转运蛋白的方法。
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公开(公告)号：US20220387382A1
公开(公告)日：2022-12-08
申请号：US17574702
申请日：2022-01-13
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20210267938A1
公开(公告)日：2021-09-02
申请号：US16952401
申请日：2020-11-19
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20200323819A1
公开(公告)日：2020-10-15
申请号：US16791118
申请日：2020-02-14
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： A61K31/381 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20 , A61K31/435 , A61K31/55 , A61K45/06
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20190125722A1
公开(公告)日：2019-05-02
申请号：US16117450
申请日：2018-08-30
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： A61K31/381 , C07D495/20 , C07D495/04 , C07D333/78 , C07D333/76 , A61K31/435 , C07D277/60 , A61K45/06 , A61K31/55 , C07D333/54
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20160083399A1
公开(公告)日：2016-03-24
申请号：US14950834
申请日：2015-11-24
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： C07D495/04
CPC分类号： A61K31/381 , A61K31/435 , A61K31/55 , A61K45/06 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
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公开(公告)号：US20140256712A1
公开(公告)日：2014-09-11
申请号：US14205859
申请日：2014-03-12
发明人： Liming SHAO , John Emmerson CAMPBELL , Michael Charles HEWITT , Una CAMPBELL , Taleen G. HANANIA
IPC分类号： C07D495/20 , C07D495/04
CPC分类号： A61K31/381 , A61K31/435 , A61K31/55 , A61K45/06 , C07D277/60 , C07D333/54 , C07D333/76 , C07D333/78 , C07D495/04 , C07D495/20
摘要： Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
摘要翻译： 本文提供多环化合物，其合成方法，包含该化合物的药物组合物及其使用方法。 本文提供的化合物可用于治疗，预防和/或治疗各种神经障碍，包括但不限于精神病和精神分裂症。
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