公开(公告)号：US20040137164A1

公开(公告)日：2004-07-15

申请号：US10745080

申请日：2003-12-23

Applicant: SURMODICS, INC.

Inventor： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC: C08G002/00

CPC classification number: C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

Abstract translation: 通过使用涂布剂和可聚合化合物在支撑体表面上形成聚合物层的方法。 涂覆剂提供适于将试剂连接到表面的光反应性基团，以及适于保持不附着于表面的光反应性基团，因此用作活化可聚合化合物的光引发剂，以在其上形成聚合物层。 本发明还提供涂层剂，以及使用这种试剂的方法以及由其制造的所得表面和装置。

公开(公告)号：US20030215419A1

公开(公告)日：2003-11-20

申请号：US10422160

申请日：2003-04-24

Applicant: SurModics, Inc

Inventor： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

IPC: A61K038/38 ,  A61K031/765 ,  A61M031/00

CPC classification number: A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.