公开(公告)号：US20030170914A1

公开(公告)日：2003-09-11

申请号：US10357679

申请日：2003-02-03

Applicant: SurModics, Inc

Inventor： Patrick E. Guire ,  Melvin J. Swanson

IPC: C12Q001/68 ,  G01N033/543

CPC classification number: C12Q1/6837 ,  B01J19/0046 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00722 ,  C40B40/06 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S977/849

Abstract: A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address sequences immobilized in the form of a patterned, and optionally random, array, b) a multi-ligand conjugate having a binding domain complementary to an address sequence, a binding domain complementary to a target sequence, and a third ligand for use in forming (e.g., by binding or polymerization) the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary sequences.

Abstract translation: 用于制备基本相同的特异性结合配体（例如，核酸）探针阵列的系统，例如通过制备和复制原始主阵列和/或通过提供能够再生的可重复使用的分析阵列。 在一个实施方案中，该系统包括a）主阵列表面的制备和使用，该主阵列表面具有以图案化和任选的阵列的形式固定的地址序列，b）具有与地址序列互补的结合结构域的多配体缀合物 ，与靶序列互补的结合结构域，以及用于将缀合物形成（例如通过结合或聚合）到测定阵列表面中或表面上的第三配体，其可以在解除地址及其使用时使用 互补序列。

公开(公告)号：US20030129130A1

公开(公告)日：2003-07-10

申请号：US10261110

申请日：2002-09-30

Applicant: SurModics, Inc.

Inventor： Patrick E. Guire ,  Kristin S. Taton ,  John V. Wall

IPC: A61K051/00 ,  A61K049/00 ,  A61K009/14

CPC classification number: B82Y5/00 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/2081 ,  A61K9/5073 ,  A61K9/5078 ,  A61K47/6927 ,  A61K47/6957 ,  A61K49/0002 ,  A61K49/1821 ,  A61K51/1244 ,  A61L27/54 ,  A61L29/18 ,  A61L31/18 ,  A61L2300/44 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/622

Abstract: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.

Abstract translation: 描述包括固定在基底上的聚合物材料基质中的微粒的表面涂层。 微粒还可以包括可用于各种应用例如医疗应用的试剂。 本发明涉及用于各种应用的表面涂层领域。 更具体地说，本发明涉及可用于通过聚合物基质固定的微粒的药物递送，成像和其它用途的表面涂层。

公开(公告)号：US20030099949A1

公开(公告)日：2003-05-29

申请号：US09972116

申请日：2001-10-05

Applicant: Surmodics, Inc.

Inventor： Patrick E. Guire ,  Kristin S. Taton

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/542 ,  B05D003/00

CPC classification number: B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00648 ,  B01J2219/00659 ,  C40B60/14

Abstract: Arrays including microparticles having probe moieties are used for the detection of a target in a sample. Microparticles are immobilized in clustered arrangements on at least a portion of a substrate. A detection scheme is performed to detect a marker associated with the target which can be bound to a probe of a clustered arrangement.

Abstract translation: 包括具有探针部分的微粒的阵列用于检测样品中的靶。 微粒在基底的至少一部分上以聚集的方式被固定。 执行检测方案以检测与可以绑定到聚类布置的探针的目标相关联的标记。

公开(公告)号：US20030073086A1

公开(公告)日：2003-04-17

申请号：US09972687

申请日：2001-10-05

Applicant: Surmodics, Inc.

Inventor： Patrick E. Guire ,  Kristin S. Taton ,  John V. Wall

IPC: C12Q001/68 ,  G01N033/53 ,  G01N033/542 ,  B05D003/00 ,  C12M001/34

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6837 ,  G01N33/54366 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/815 ,  Y10S530/816 ,  C12Q2563/149

Abstract: Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.

Abstract translation: 包括具有探针和标记物部分的微粒的阵列用于检测样品中的靶。 微粒随机固定在底物的至少一部分上。 执行检测方案以检测与微粒相关的标记和探针的身份以及与探针结合的任何靶标。

公开(公告)号：US20030215419A1

公开(公告)日：2003-11-20

申请号：US10422160

申请日：2003-04-24

Applicant: SurModics, Inc

Inventor： Patrick E. Guire ,  Aron B. Anderson ,  Richard A. Amos ,  Terrence P. Everson

IPC: A61K038/38 ,  A61K031/765 ,  A61M031/00

CPC classification number: A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

公开(公告)号：US20030148360A1

公开(公告)日：2003-08-07

申请号：US10346691

申请日：2003-01-15

Applicant: SurModics, Inc.

Inventor： Patrick E. Guire ,  Melvin J. Swanson

IPC: C12Q001/68 ,  G01N033/53 ,  C12M001/34 ,  G01N033/543

CPC classification number: C12Q1/6837 ,  B01J19/0046 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00722 ,  C40B40/06 ,  C12Q2525/179 ,  C12Q2525/161 ,  C12Q2565/515

Abstract: A system for producing substantially identical specific binding ligand probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address ligands immobilized thereon, b) a multi-ligand conjugate having a binding domain complementary to an address ligand, a binding domain complementary to a target ligand, and a third ligand for use in transferring the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary ligands.

Abstract translation: 用于制备基本相同的特异性结合配体探针阵列的系统，例如通过制备和复制原始主阵列和/或通过提供能够再生的可重复使用的测定阵列。 在一个实施方案中，该系统包括a）具有固定在其上的地址配体的主阵列表面的制备和用途，b）具有与地址配体互补的结合结构域，与靶配体互补的结合结构域的多配体缀合物，以及 用于将缀合物转移到测定阵列表面中或其上的第三配体，其可以与解离地址及其互补配体一起使用或分离。

公开(公告)号：US20030148308A1

公开(公告)日：2003-08-07

申请号：US10192917

申请日：2002-07-09

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Sheau-Ping Hu ,  Dale G. Swan ,  Melvin J. Swanson ,  Patrick E. Guire

IPC: C12Q001/68 ,  C12M001/34 ,  B05D003/00

CPC classification number: B82Y30/00 ,  B01J2219/00317 ,  B01J2219/00531 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00711 ,  B01J2219/00716 ,  B01J2219/00722 ,  C07B2200/11 ,  C07C45/63 ,  C07C235/84 ,  C07C323/42 ,  C07H21/00 ,  C12Q1/6834 ,  C40B40/06 ,  C40B60/14 ,  C07C49/813

Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.