公开(公告)号：US11485700B2

公开(公告)日：2022-11-01

申请号：US17255590

申请日：2018-06-28

Applicant: SYMRISE AG

Inventor： Bernd Fiebich ,  Matthias Winkler ,  Marcus Rudolf Götz ,  Oskar Koch

IPC: C07C67/02 ,  C07C37/50 ,  C07C67/32 ,  C07C67/03 ,  C07C67/30

Abstract: The present invention relates to a method of producing a compound of formula (I) or a salt of a compound of formula (I). The invention also relates to a compound of formula (I) or a salt of a compound of formula (I) for use in a therapeutic method to achieve one or more therapeutic effects as well as for use in the treatment and/or prevention of certain diseases. Furthermore, the invention provides a pharmaceutical composition comprising one or more compound(s) of formula (I) or salt(s) of compound(s) of formula (I).

公开(公告)号：US11338001B2

公开(公告)日：2022-05-24

申请号：US16478514

申请日：2018-01-17

Applicant: SYMRISE AG ,  PROBI AB

Inventor： Marcus Rudolf Götz ,  Kerstin Holmgren ,  Niklas Larsson ,  Bernd Fiebich ,  William Wade

IPC: A61K35/747 ,  A61K9/00

Abstract: The present invention relates to certain microorganisms or mixtures thereof for use in the treatment and/or prevention of inflammation in the oral cavity, preferably for the treatment and/or prevention of gingivitis and/or peridontitis.
In particular, the present invention relates to microorganisms or mixtures thereof for use as probiotic agents for forming co-aggregates with microorganisms associated with gingivitis and/or peridontitis.
Furthermore, the present invention provides oral pharmaceutical compositions, oral care products or products for nutrition or pleasure comprising one or more of the probiotic microorganisms as active agents as well as a method of production thereof.

公开(公告)号：US11020441B2

公开(公告)日：2021-06-01

申请号：US16070553

申请日：2017-01-18

Applicant: SYMRISE AG ,  PROBI AB

Inventor： Marcus Rudolf Götz ,  Kerstin Holmgren ,  Niklas Larsson ,  Bernd Fiebich ,  William Wade

IPC: A61K35/747 ,  A61K8/99 ,  A61K45/06 ,  A61K9/20 ,  A61K9/28 ,  A61Q11/00 ,  A61K9/68

Abstract: The present invention relates to certain microorganisms or mixtures thereof for use in the treatment and/or prevention of inflammation in the oral cavity, in particular for use in the treatment and/or prevention of dental caries and/or periodontal disease.
In particular, the present invention relates to microorganisms or mixtures thereof for use as an anti-inflammatory agent in the oral cavity for reducing or inhibiting the release of certain inflammatory factors.
Furthermore, the present invention provides oral pharmaceutical compositions, oral care products or products for nutrition or pleasure comprising one or more of the microorganisms as probiotic agents as well as a method of production thereof.