公开(公告)号：US11485700B2

公开(公告)日：2022-11-01

申请号：US17255590

申请日：2018-06-28

Applicant: SYMRISE AG

Inventor： Bernd Fiebich ,  Matthias Winkler ,  Marcus Rudolf Götz ,  Oskar Koch

IPC: C07C67/02 ,  C07C37/50 ,  C07C67/32 ,  C07C67/03 ,  C07C67/30

Abstract: The present invention relates to a method of producing a compound of formula (I) or a salt of a compound of formula (I). The invention also relates to a compound of formula (I) or a salt of a compound of formula (I) for use in a therapeutic method to achieve one or more therapeutic effects as well as for use in the treatment and/or prevention of certain diseases. Furthermore, the invention provides a pharmaceutical composition comprising one or more compound(s) of formula (I) or salt(s) of compound(s) of formula (I).

公开(公告)号：US11964955B2

公开(公告)日：2024-04-23

申请号：US17113248

申请日：2020-12-07

Applicant: SYMRISE AG

Inventor： Oskar Koch ,  Marcus Rudolf Götz

IPC: C07D311/80 ,  A61K31/235 ,  A61K31/352 ,  C07C37/50 ,  C07C39/23 ,  C07C67/03 ,  C07C67/343 ,  C07C69/94

CPC classification number: C07D311/80 ,  A61K31/235 ,  A61K31/352 ,  C07C37/50 ,  C07C39/23 ,  C07C67/03 ,  C07C67/343 ,  C07C69/94 ,  A61K2300/00 ,  C07C2601/14 ,  C07C2601/16 ,  A61K31/235 ,  A61K2300/00 ,  A61K31/352 ,  A61K2300/00 ,  C07C67/343 ,  C07C69/94 ,  C07C67/03 ,  C07C69/94 ,  C07C37/50 ,  C07C39/23

Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production.




Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body.
Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.

公开(公告)号：US11123272B2

公开(公告)日：2021-09-21

申请号：US16465228

申请日：2016-12-02

Applicant: Symrise AG

Inventor： Caroline Baptiste ,  Aurélie Trunet ,  Gabriele Vielhaber ,  Sabine Lange ,  Dominik Stuhlmann ,  Benoit Join ,  Oskar Koch

IPC: A61K8/34 ,  A61Q19/00 ,  A61Q19/10 ,  A61Q15/00 ,  A61Q5/02 ,  A61Q19/08 ,  A61Q17/04 ,  A61Q11/00

Abstract: Suggested is a cosmetic blend, comprising or consisting of (a) at least one TRPV1 and/or TRPV3 modulator and (b1) at least one 1,2-alkandiol having 5 to 12 carbon atoms and/or (b2) at least one polyol having 3 to 12 carbon atoms and 3 to 6 hydroxyl groups.

公开(公告)号：US10913729B2

公开(公告)日：2021-02-09

申请号：US16181503

申请日：2018-11-06

Applicant: SYMRISE AG

Inventor： Oskar Koch ,  Marcus Rudolf Götz

IPC: C07D311/80 ,  A61K31/235 ,  C07C69/94 ,  A61K31/352 ,  C07C67/03 ,  C07C67/343 ,  C07C37/50 ,  C07C39/23

Abstract: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body.
Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.

公开(公告)号：US10442751B2

公开(公告)日：2019-10-15

申请号：US15547435

申请日：2016-01-13

Applicant: SYMRISE AG

Inventor： Atia Hanan ,  Reinhard Eckelt ,  Angela Koeckritz ,  Johannes Panten ,  Peter Esser ,  Oskar Koch

IPC: C07F9/09 ,  C07C45/69 ,  C07C68/00 ,  C07C69/12 ,  C07C69/14 ,  C07C69/96 ,  C07C303/24 ,  C07C49/497 ,  C07C49/503 ,  C07C51/353 ,  C07C67/293

Abstract: The present invention relates to a method for producing a substituted alkyl cycloalkanone, comprising the alkylation of a cycloalkanone with an alkene derivative in the presence of a metal oxide, where n is 2 to 20, m is 0 to 10, and R is a functional group.

公开(公告)号：US10988434B2

公开(公告)日：2021-04-27

申请号：US16471422

申请日：2017-09-27

Applicant: SYMRISE AG

Inventor： Vijayanand Chandrasekaran ,  Johannes Panten ,  Oskar Koch ,  Edison Diaz Gomez

IPC: A61K8/18 ,  A61Q13/00 ,  A61K8/00 ,  C07C69/593 ,  C07C51/56 ,  C07C67/12 ,  C07C67/333 ,  C07D307/36

Abstract: A fragrance mixture and its applications, in particular perfume oils, cosmetic agents, application agents or washing and cleaning agents, containing a sensory effective amount of (i) (E)-2-methyl-but-2-endicarboxylic acid diethyl ester, (ii) (Z)-2-methyl-but-2-endicarboxylic acid diethyl ester or (iii) 2-methylenebutanedicarboxylic acid diethyl ester and mixtures thereof and analogous esters derived from these compounds and mixtures.

公开(公告)号：US20200010402A1

公开(公告)日：2020-01-09

申请号：US16471422

申请日：2017-09-27

Applicant: SYMRISE AG

Inventor： Vijayanand Chandrasekaran ,  Johannes Panten ,  Oskar Koch ,  Edison Diaz Gomez

IPC: C07C69/593 ,  C07C67/333 ,  C07C67/12 ,  C07C51/56 ,  C07D307/36

Abstract: A fragrance mixture and its applications, in particular perfume oils, cosmetic agents, application agents or washing and cleaning agents, containing a sensory effective amount of (i) (E)-2-methyl-but-2-endicarboxylic acid diethyl ester, (ii) (Z)-2-methyl-but-2-endicarboxylic acid diethyl ester or (iii) 2-methylenebutanedicarboxylic acid diethyl ester and mixtures thereof and analogous esters derived from these compounds and mixtures.

公开(公告)号：US09670133B2

公开(公告)日：2017-06-06

申请号：US14653044

申请日：2014-06-30

Applicant: SYMRISE AG

Inventor： Oskar Koch ,  Marcus Rudolf Götz ,  Jan Looft ,  Tobias Vössing

IPC: C07C69/94 ,  A61K31/05 ,  C07C67/29 ,  C07C37/50 ,  A61K31/235 ,  A61K31/352

CPC classification number: C07C69/94 ,  A61K31/05 ,  A61K31/235 ,  A61K31/352 ,  C07C37/50 ,  C07C67/29 ,  C07C2601/16 ,  A61K2300/00

Abstract: Specific compositions comprising one or multiple (cannabinoid) compound(s) of formula (A) and/or one or multiple salt(s) thereof are described as well as methods for their manufacture. A compound of formula (A), a salt of formula (A) and a respective composition for use as medicine and for use in a method for the therapeutic treatment of the human or animal body, respectively, are also described.Furthermore, corresponding pharmaceutical formulations, cosmetic preparations and foodstuff and/or gourmet or snack preparations fit for consumption as well as a method for the manufacture of delta-9-tetrahydrocannabinol are described.

公开(公告)号：US20160100574A1

公开(公告)日：2016-04-14

申请号：US14893720

申请日：2014-05-20

Applicant: SYMRISE AG

Inventor： Manuel Pesaro ,  Oskar Koch ,  Gerhard Schmaus ,  Antje Köhler ,  Jessica Grieger

IPC: A01N31/04 ,  A61Q5/00 ,  A61K8/34 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q17/04 ,  A61Q5/06 ,  A61Q11/00 ,  C11D3/48 ,  C11B9/00 ,  A61Q13/00 ,  C11D3/20 ,  A23L3/3463 ,  A61Q15/00

CPC classification number: A01N31/04 ,  A01N31/02 ,  A23L3/34635 ,  A23V2002/00 ,  A61K8/34 ,  A61K8/345 ,  A61K2800/524 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q9/04 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q17/005 ,  A61Q17/04 ,  A61Q19/002 ,  A61Q19/004 ,  A61Q19/005 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10 ,  C11B9/00 ,  C11D3/2068 ,  C11D3/48

Abstract: Suggested is an antimicrobial agent comprising at least one glycerylether of formula (I) in which R1 represents a benzyl, methylbenzyl, phenlethyl, or phenylpropyl radical, or a glycerylether of formula (II) in which R2 stands for a linear or branched alkyl radical having 2 to 12 carbon atoms, on condition that in case of glycerylethers of formula (II) two or three of said species are present.

Abstract translation: 建议包含至少一种式（I）的糖精醚的抗微生物剂，其中R 1表示苄基，甲基苄基，苯乙基或苯基丙基，或式（II）的糖基醚，其中R 2表示直链或支链烷基， 2至12个碳原子，条件是在式（II）的糖衣醚的情况下，存在所述物质的两个或三个。

公开(公告)号：US09820923B2

公开(公告)日：2017-11-21

申请号：US14896824

申请日：2014-06-04

Applicant: Symrise AG

Inventor： Dominik Stuhlmann ,  Imke Meyer ,  Oskar Koch ,  Helko Oertling ,  Martina Herrmann ,  Claudia Gömann

IPC: A61K8/00 ,  A61K8/42 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C07C235/74 ,  A61K8/49 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/04

CPC classification number: A61K8/42 ,  A61K8/4926 ,  A61K2800/48 ,  A61K2800/522 ,  A61K2800/524 ,  A61K2800/591 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  C07C235/74

Abstract: The invention relates generally to new compounds of formula (I), wherein R1, R′1, R2, R′2, R3, R′3, R4 R′4, R5, R′5, R6, R7 are independently of one another and denote hydrogen, hydroxyl, C1 to C6-alkyl group or R6 and R7 form together a C5-C6 ring system, and wherein n=0, 1, 2, 3, or 4. Moreover, the invention relates to the use of one or more compounds of formula (I) in cosmetic or pharmaceutical compositions, which are preferably dermatological compositions and are preferably used topically.