公开(公告)号：US20160281118A1

公开(公告)日：2016-09-29

申请号：US15011855

申请日：2016-02-01

Applicant: SYMRISE AG

Inventor： GERHARD KRAMMER ,  JAKOB PETER LEY ,  KATRIN GEIßLER ,  TORSTEN GEIßLER ,  FRAUKE GOMOLL ,  PETER WELTERS ,  GUIDO JACH ,  LUDGER WESSJOHANN

IPC: C12P13/02 ,  C12N9/10 ,  C12P13/00 ,  C12P7/22 ,  C12P7/62

CPC classification number: C12P13/02 ,  A23L27/204 ,  A23L27/24 ,  A23V2002/00 ,  C12N9/1007 ,  C12N9/1085 ,  C12P7/22 ,  C12P7/40 ,  C12P7/42 ,  C12P7/62 ,  C12P13/001 ,  C12Y201/01 ,  C12Y205/01006

Abstract: The invention relates to providing both fermentative and biotechnological methods for producing 3,4-methylized cinnamic acids, 3,4-methylized cinnamic acid esters, 3,4-dimethoxyphenethylamine, and 4-methylized cinnamic acid amides using a 4′-O-methyltransferase, optionally in combination with further enzymes, wherein the enzymes are selected by means of metabolic engineering and operation have been adapted by targeted optimization, and compositions obtained by means of the method.The invention further relates to vector systems, recombinant microorganisms or fungi, and specific nucleic acid segments and polypeptides.

Abstract translation: 本发明还涉及载体系统，重组微生物或真菌，以及特异性核酸区段和多肽。