公开(公告)号：US20170251950A1

公开(公告)日：2017-09-07

申请号：US15599817

申请日：2017-05-19

申请人： Synaptive Medical (Barbados) Inc.

发明人： Cameron A. Piron ,  Jeff Stainsby ,  Chad Harris

IPC分类号： A61B5/055 ,  G01R33/563 ,  A61B5/03 ,  A61B5/00

CPC分类号： A61B5/055 ,  A61B5/031 ,  A61B5/032 ,  A61B5/4058 ,  A61B5/4076 ,  A61B5/4809 ,  A61B2576/00 ,  G01R33/56341 ,  G01R33/56366

摘要： Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

公开(公告)号：US20170186180A1

公开(公告)日：2017-06-29

申请号：US15327450

申请日：2014-09-18

申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.

发明人： Cameron A. Piron ,  Jeff Stainsby

IPC分类号： G06T7/33 ,  G06T7/00

CPC分类号： G06T7/33 ,  G06T3/0068 ,  G06T7/0012 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10124 ,  G06T2207/30008 ,  G06T2207/30016

摘要： Systems and methods for co-registering medical images obtained with different imaging modalities are provided. For instance, images obtained with x-ray imaging, such as x-ray computed tomography (“CT”), can be co-registered with images obtained with magnetic resonance imaging (“MRI”). The different imaging modalities generate images that have different visualization characteristics for tissues; thus, in general, co-registration is accomplished by identifying different anatomical features in the different images and then utilizing a known spatial relationship between those anatomical features to co-register the different images.

公开(公告)号：US20180210053A1

公开(公告)日：2018-07-26

申请号：US15745169

申请日：2015-07-16

申请人： Synaptive Medical (Barbados) Inc.

发明人： Cameron A. Piron ,  Jeff Stainsby ,  Chad Harris ,  Phillip Beatty

IPC分类号： G01R33/54 ,  A61B5/055 ,  A61B5/00 ,  G01R33/561

CPC分类号： G01R33/543 ,  A61B5/0037 ,  A61B5/035 ,  A61B5/037 ,  A61B5/055 ,  A61B5/7285 ,  G01R33/561

摘要： Systems and methods for adaptive, multi-resolution magnetic resonance imaging (“MRI”], in which an MRI scan prescription is adaptively changed to acquire high-quality data from select regions-of-interest (“ROI”] in a larger field-of-view (“FOV”), are provided. The higher quality data can include data representing higher spatial resolution, higher signal-to-noise ratio (“SNR”], increased diffusion encoding via repeated acquisition with a larger number of diffusion-encoding directions, and so on. A composite image can be generated that displays the higher quality images of the ROIs overlaid on the larger FOV.

公开(公告)号：US20160367166A1

公开(公告)日：2016-12-22

申请号：US14903029

申请日：2015-02-19

申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.

发明人： Cameron Piron ,  Jeff Stainsby ,  Chad Harris

IPC分类号： A61B5/055 ,  G01R33/563 ,  A61B5/03

CPC分类号： A61B5/055 ,  A61B5/031 ,  A61B5/032 ,  A61B5/4058 ,  A61B5/4076 ,  A61B5/4809 ,  A61B2576/00 ,  G01R33/56341 ,  G01R33/56366

摘要： Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

摘要翻译： 描述了使用磁共振成像（“MRI”）提供脑脊液全球血液流量（“CSF”）的定量测​​量的系统和方法。 一般来说，使用设计为对CSF的血液流动特别敏感的流敏MRI技术从受试者获得图像。 当受试者处于清醒状态时，并且当受试者处于睡眠状态时，可以获得血液流量的测量。 基于这两个测量，可以产生指示神经系统状态或疾病的生物标志物。

公开(公告)号：US10311586B2

公开(公告)日：2019-06-04

申请号：US15327450

申请日：2014-09-18

申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.

发明人： Cameron A. Piron ,  Jeff Stainsby

IPC分类号： G06T3/00 ,  G06T7/00 ,  G06T7/33

摘要： Systems and methods for co-registering medical images obtained with different imaging modalities are provided. For instance, images obtained with x-ray imaging, such as x-ray computed tomography (“CT”), can be co-registered with images obtained with magnetic resonance imaging (“MRI”). The different imaging modalities generate images that have different visualization characteristics for tissues; thus, in general, co-registration is accomplished by identifying different anatomical features in the different images and then utilizing a known spatial relationship between those anatomical features to co-register the different images.

公开(公告)号：US09681821B2

公开(公告)日：2017-06-20

申请号：US14903029

申请日：2015-02-19

申请人： SYNAPTIVE MEDICAL (BARBADOS) INC.

发明人： Cameron Piron ,  Jeff Stainsby ,  Chad Harris

IPC分类号： A61B5/055 ,  A61B5/00 ,  A61B5/03 ,  G01R33/563

CPC分类号： A61B5/055 ,  A61B5/031 ,  A61B5/032 ,  A61B5/4058 ,  A61B5/4076 ,  A61B5/4809 ,  A61B2576/00 ,  G01R33/56341 ,  G01R33/56366

摘要： Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.