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1.发明授权Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth 失效噻唑烷二酮单独或与其他治疗剂组合用于抑制或减少肿瘤生长公开(公告)号：US07323481B2
公开(公告)日：2008-01-29
申请号：US10474443
申请日：2002-04-04
IPC分类号： A61K31/425
CPC分类号： A61K31/425 , C07D417/12 , C07D417/14
摘要： Use of thiazolidinedione derivatives for the preparation of medicaments for inhibiting or reducing tumour growth or metastases, alone or in combination with an RXR agonist or well-known antitumour agent.
摘要翻译： 噻唑烷二酮衍生物用于制备用于抑制或减少肿瘤生长或转移的药物，单独或与RXR激动剂或众所周知的抗肿瘤剂组合。
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2.发明申请Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth 失效噻唑烷二酮单独或与其他治疗剂组合用于抑制或减少肿瘤生长公开(公告)号：US20050176787A1
公开(公告)日：2005-08-11
申请号：US10474443
申请日：2002-04-04
IPC分类号： A61K31/203 , A61K31/425 , A61K31/427 , A61P35/00 , A61P43/00 , C07D417/12 , C07D417/14
CPC分类号： A61K31/425 , C07D417/12 , C07D417/14
摘要： Use of thiazolidinedione derivatives for the preparation of medicaments for inhibiting or reducing tumour growth or metastases, alone or in combination with an RXR agonist or well-known antitumour agent.
摘要翻译： 噻唑烷二酮衍生物用于制备用于抑制或减少肿瘤生长或转移的药物，单独或与RXR激动剂或众所周知的抗肿瘤剂组合。
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公开(公告)号：US20070266448A1
公开(公告)日：2007-11-15
申请号：US11801614
申请日：2007-05-08
IPC分类号： A01K67/027 , C12P21/04
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及一种从无限非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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公开(公告)号：US20100105073A1
公开(公告)日：2010-04-29
申请号：US12603642
申请日：2009-10-22
IPC分类号： G01N33/53 , C12P21/08 , C12N5/0781
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及从免疫缺陷型非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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公开(公告)号：US20120195903A1
公开(公告)日：2012-08-02
申请号：US13443917
申请日：2012-04-11
IPC分类号： A61K39/395 , C12N5/0781 , C12P21/08 , G01N33/577
CPC分类号： C12P21/00 , C07K16/00 , C07K16/2866 , C07K16/32 , C12N5/0635
摘要： The current invention is related to a method for the production of a human monoclonal antibody from a immundeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
摘要翻译： 本发明涉及一种从无限非人动物制备人单克隆抗体的方法，所述方法包括使新的免疫缺陷型非人动物与人胎肝干细胞（FL细胞）接触以产生 免疫移植的非人动物（重构动物），随后使所述重建的动物与抗原接触，从所述重建的动物收集产生针对所述抗原的人抗体的人细胞，并从所述抗体产生细胞中分离所述抗体。
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