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公开(公告)号：US20060183215A1
公开(公告)日：2006-08-17
申请号：US11335612
申请日：2006-01-20
申请人： Sachihiro Youoku , Moritoshi Ando , Akio Ito
发明人： Sachihiro Youoku , Moritoshi Ando , Akio Ito
IPC分类号： C12M1/34
CPC分类号： A61K48/0075 , C12M35/00
摘要： A particle fixing unit fixes a particle. A needle is arranged in such a manner that an angle between a surface on a side of the particle fixing unit on which the particle is fixed and a longitudinal center axis of the needle becomes equal to or more than 45 degrees and equal to or less than 135 degrees. An image forming unit forms, when observing at least one of the particle and the needle across the particle fixing unit, at least one of an image of the particle and an image of the needle, based on a light transmitted through the particle fixing unit.
摘要翻译： 颗粒固定单元固定颗粒。 针以这样的方式配置，使得固定有颗粒的颗粒固定单元的一侧表面与针的纵向中心轴之间的角度等于或大于45度并且等于或小于 135度。 当通过颗粒固定单元观察至少一个颗粒和针时，图像形成单元基于透过颗粒固定单元的光来形成颗粒的图像和针的图像中的至少一个。
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公开(公告)号：US20070146483A1
公开(公告)日：2007-06-28
申请号：US11402821
申请日：2006-04-13
申请人： Moritoshi Ando , Sachihiro Youoku , Akio Ito
发明人： Moritoshi Ando , Sachihiro Youoku , Akio Ito
IPC分类号： H04N7/18
摘要： A capturing unit captures an image of a designated position in a culture medium. A first creating unit creates a wide-field image by synthesizing a plurality of images of the designated position and a periphery of the designated position captured by the capturing unit. A second creating unit creates a narrow-field image using the image of the designated position. A displaying unit arranges and displays the wide-field image and the narrow-field image.
摘要翻译： 捕获单元捕获培养基中指定位置的图像。 第一创建单元通过合成指定位置的多个图像和由捕获单元捕获的指定位置的周边来创建广域图像。 第二创建单元使用指定位置的图像创建窄场图像。 显示单元布置并显示宽场图像和窄场图像。
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公开(公告)号：US20070048857A1
公开(公告)日：2007-03-01
申请号：US11288280
申请日：2005-11-29
申请人： Akio Ito , Akihiko Yabuki , Satoru Sakai , Moritoshi Ando , Sachihiro Youoku
发明人： Akio Ito , Akihiko Yabuki , Satoru Sakai , Moritoshi Ando , Sachihiro Youoku
IPC分类号： C12M1/00
CPC分类号： B01L3/50857 , B01L3/5085
摘要： A cell trapping plate traps a cell by applying a negative pressure suction through a trapping hole provided therein. A capillary needle is stuck into the trapped cell to inject an injectant. The cell trapping plate includes trapping holes arranged at irregular intervals in directions of two coordinate axes in a two-dimensional orthogonal coordinate system.
摘要翻译： 细胞捕获板通过施加负压吸引通过设置在其中的捕集孔来捕获细胞。 将毛细针塞在被捕获的细胞中以注入注射剂。 细胞捕获板包括在二维正交坐标系中以两个坐标轴的方向以不规则的间隔布置的捕获孔。
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公开(公告)号：US07936939B2
公开(公告)日：2011-05-03
申请号：US11600815
申请日：2006-11-17
申请人： Moritoshi Ando , Sachihiro Youoku
发明人： Moritoshi Ando , Sachihiro Youoku
CPC分类号： C12M35/00
摘要： A microinjection apparatus, which injects an object into a cell with a needle, acquires a first image that is an image of the cell at a first focal position and a second image that is an image of the cell at a second focal position, and decides a state of the cell based on a difference image obtained from the first image and the second image. Execution of such sequence of processing makes it possible to measure a state of a cell without involving human work and confirm the state of the cell in performing a microinjection, without a necessity of experienced skill, efficiently, and simply.
摘要翻译： 用针注入物体的显微注射装置获取作为第一焦点位置处的细胞的图像的第一图像和作为第二焦点位置处的细胞的图像的第二图像，并且决定 基于从第一图像和第二图像获得的差异图像的单元格的状态。 这种处理顺序的执行使得可以在不涉及人工作的情况下测量细胞的状态，并且无需有经验的技能，有效且简单地确认进行显微注射的细胞的状态。
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公开(公告)号：US20080002868A1
公开(公告)日：2008-01-03
申请号：US11600815
申请日：2006-11-17
申请人： Moritoshi Ando , Sachihiro Youoku
发明人： Moritoshi Ando , Sachihiro Youoku
IPC分类号： G06K9/00
CPC分类号： C12M35/00
摘要： A microinjection apparatus, which injects an object into a cell with a needle, includes an image acquiring unit that acquires a first image that is an image of the cell at a first focal position and a second image that is an image of the cell at a second focal position; and a state deciding unit that decides a state of the cell based on a difference image obtained from the first image and the second image.
摘要翻译： 一种用针将物体注射到细胞中的显微注射装置包括图像获取单元，其获取作为第一焦点位置处的细胞的图像的第一图像和作为细胞的图像的第二图像， 第二焦点; 以及状态判定单元，其基于从所述第一图像和所述第二图像获得的差分图像来决定所述单元的状态。
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公开(公告)号：US20080126051A1
公开(公告)日：2008-05-29
申请号：US11601626
申请日：2006-11-20
申请人： Moritoshi Ando , Sachihiro Youoku
发明人： Moritoshi Ando , Sachihiro Youoku
CPC分类号： G01N35/1009 , C12M35/00
摘要： A microinjection apparatus of the present invention includes a needle-position polarity detecting unit that detects a position of the needle in the vertical direction at which a value of a differential aggregate distribution becomes the maximum in the situation in which a shape of the leading edge of the needle at a focal position narrows at the right. Moreover, a differential-average determining unit, based on a differential average of an image near the position detected by the needle-position polarity detecting unit, determines the lowest allowable position of the needle, which is a position at which a differential average exceeds a predetermined threshold.
摘要翻译： 本发明的显微注射装置包括：针位置极性检测单元，其检测在所述针头的前缘的形状的情况下的所述针在所述上下方向上的位置的位置， 焦点处的针在右侧变窄。 此外，差分平均确定单元基于由针位置极性检测单元检测到的位置附近的图像的差分平均值，确定针的最低允许位置，该位置是差分平均值超过 预定阈值。
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公开(公告)号：US20060166351A1
公开(公告)日：2006-07-27
申请号：US11213948
申请日：2005-08-30
IPC分类号： C12M1/34
摘要： A path defines an opening smaller than a cell in a cell capturing apparatus. A negative pressure generating device is connected to the path so as to generate negative pressure within the path. A negative pressure controlling device is connected to the path so as to adjust the negative pressure within the path. A cell is caught at the opening of the path based on the negative pressure. The negative pressure controlling device serves to maintain the negative pressure constant within the path. Even if the negative pressure changes within the path based on drop or rise in the temperature within the path, for example, the negative pressure can be adjusted at a level suitable for the caught cell with the assistance of the negative pressure controlling device. The cell can reliably be kept immobilized at the opening of the path.
摘要翻译： 路径定义小于细胞捕获装置中的细胞的开口。 负压生成装置与路径连接，从而在路径内产生负压。 负压控制装置连接到路径上，以便调节路径内的负压。 基于负压，电池被捕获在路径的开口处。 负压控制装置用于将负压维持在通路内。 即使基于路径内的温度下降或上升，负压在路径内变化，例如也可以在负压控制装置的帮助下将负压调整到适合被捕获的电池的水平。 细胞可以可靠地固定在路径的开口处。
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公开(公告)号：US07881533B2
公开(公告)日：2011-02-01
申请号：US11601626
申请日：2006-11-20
申请人： Moritoshi Ando , Sachihiro Youoku
发明人： Moritoshi Ando , Sachihiro Youoku
IPC分类号： G06K9/34
CPC分类号： G01N35/1009 , C12M35/00
摘要： A microinjection apparatus of the present invention includes a needle-position polarity detecting unit that detects a position of the needle in the vertical direction at which a value of a differential aggregate distribution becomes the maximum in the situation in which a shape of the leading edge of the needle at a focal position narrows at the right. Moreover, a differential-average determining unit, based on a differential average of an image near the position detected by the needle-position polarity detecting unit, determines the lowest allowable position of the needle, which is a position at which a differential average exceeds a predetermined threshold.
摘要翻译： 本发明的显微注射装置包括：针位置极性检测单元，其检测在所述针头的前缘的形状的情况下的所述针在所述上下方向上的位置的位置， 焦点处的针在右侧变窄。 此外，差分平均确定单元基于由针位置极性检测单元检测到的位置附近的图像的差分平均值，确定针的最低可允许位置，其是差分平均值超过 预定阈值。
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公开(公告)号：US07534598B2
公开(公告)日：2009-05-19
申请号：US11067351
申请日：2005-02-28
申请人： Moritoshi Ando , Satoru Sakai
发明人： Moritoshi Ando , Satoru Sakai
CPC分类号： C12M35/02
摘要： A surface of a cell is irradiated with laser beam to make an opening in the cell membrane, and a drug fluid is inserted in the cell through the opening.
摘要翻译： 用激光束照射细胞的表面以在细胞膜中形成开口，并且药物流体通过开口插入细胞中。
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公开(公告)号：US20050247895A1
公开(公告)日：2005-11-10
申请号：US11116175
申请日：2005-04-28
申请人： Moritoshi Ando , Satoru Sakai
发明人： Moritoshi Ando , Satoru Sakai
CPC分类号： G01N21/896 , G01N2021/9513 , G01N2201/1085
摘要： A surface inspecting apparatus that inspects a surface of a material based on an intensity of a reflected light from the surface includes an illuminating unit that illuminates a light on the surface; and a detecting unit that detects the intensity of the reflected light from the surface. The light has an intensity distribution in which an intensity of the light is higher approaching the surface.
摘要翻译： 基于来自表面的反射光的强度检查材料的表面的表面检查装置包括：照射表面上的光的照明单元; 以及检测单元，其检测来自表面的反射光的强度。 光具有强度分布，其中光的强度较高地接近表面。
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