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    Molding apparatus
    1.
    发明授权
    Molding apparatus 有权
    成型设备

    公开(公告)号：US07901200B2

    公开(公告)日：2011-03-08

    申请号：US11655080

    申请日：2007-01-19

    申请人： Takashi Satoh ,  Sadaki Satoh ,  Ken Kikuchi ,  Masashi Gotoh ,  Takeshi Itoh ,  Takuo Kataho

    发明人： Takashi Satoh ,  Sadaki Satoh ,  Ken Kikuchi ,  Masashi Gotoh ,  Takeshi Itoh ,  Takuo Kataho

    IPC分类号： B29C43/04

    CPC分类号： B30B15/304 ,  B22F3/03 ,  B30B11/04

    摘要： A lower punch is arranged to be inserted into a cavity of a die from a lower side of the die. A upper punch is arranged to be inserted into the cavity from an upper side of the die to compact the powder filled in the cavity, in cooperation with the lower punch. A feeder supplies the powder into the cavity. A first cam driving system has a first cam for vertically moving the die relative to the lower punch. A second cam driving system has a second cam for vertically moving the upper punch. A third cam driving system has a third cam for moving the feeder forward or backward relative to the cavity. A contact member is connected to the first cam driving system. A stopper is located above or below the contact member and regulates relative vertical movement of the die with respect to the lower punch, in cooperation with the contact member. A fourth cam driving system has a fourth cam for vertically moving the stopper. The first cam, the second cam, the third cam, and the fourth cam are rotated in synchronism.

    摘要翻译： 下冲头布置成从模具的下侧插入模具的空腔中。 上冲头布置成从模具的上侧插入空腔中，以与下冲头配合来压实填充在空腔中的粉末。 馈线将粉末供应到空腔中。 第一凸轮驱动系统具有用于相对于下冲头垂直移动模具的第一凸轮。 第二凸轮驱动系统具有用于垂直移动上冲头的第二凸轮。 第三凸轮驱动系统具有用于相对于腔向前或向后移动进给器的第三凸轮。 接触构件连接到第一凸轮驱动系统。 塞子位于接触构件的上方或下方，并且与接触构件协调地调节模具相对于下冲头的相对垂直运动。 第四凸轮驱动系统具有用于垂直移动止动件的第四凸轮。 第一凸轮，第二凸轮，第三凸轮和第四凸轮同步旋转。

    Molding die unit
    2.
    发明申请
    Molding die unit 有权
    成型模具单元

    公开(公告)号：US20070178184A1

    公开(公告)日：2007-08-02

    申请号：US11655068

    申请日：2007-01-19

    申请人： Sadaki Satoh ,  Masashi Gotoh ,  Ken Kikuchi ,  Takeshi Itoh ,  Takuo Kataho

    发明人： Sadaki Satoh ,  Masashi Gotoh ,  Ken Kikuchi ,  Takeshi Itoh ,  Takuo Kataho

    IPC分类号： B29C47/08

    CPC分类号： B22F3/03 ,  B29C43/361 ,  B29C2043/3618 ,  B29K2105/251

    摘要： A molding die unit has a shell and a die. The die is located inside the shell. A die hole is formed in the die. The die has first and second portions. The first and second portions include their respective surfaces defining the die hole and facing each other. A first through hole is formed in the shell and penetrates so as to open in an outside surface and in an inside surface of the shell. A second through hole continuing to the first through hole is formed at a position corresponding to the first through hole and in the first portion. The second through hole includes a first region and a second region. The first region opens in a surface of the first portion facing the inside surface of the shell and has a first sectional area. The second region opens in the surface defining the die hole and has a second sectional area smaller than the first sectional area.

    摘要翻译： 成型模具单元具有壳体和模具。 模具位于壳体内。 在模具中形成模孔。 模具具有第一和第二部分。 第一和第二部分包括它们各自的表面，其界定模具孔并面对彼此。 第一通孔形成在壳体中并穿透以在壳体的外表面和内表面中打开。 在与第一通孔相对应的位置和第一部分中形成有连续到第一通孔的第二通孔。 第二通孔包括第一区域和第二区域。 第一区域在面向壳体的内表面的第一部分的表面中开口并且具有第一截面积。 第二区域在限定模孔的表面中开口，并且具有小于第一截面积的第二截面面积。

    Molding apparatus
    3.
    发明申请
    Molding apparatus 有权
    成型设备

    公开(公告)号：US20070231420A1

    公开(公告)日：2007-10-04

    申请号：US11655080

    申请日：2007-01-19

    申请人： Takashi Satoh ,  Sadaki Satoh ,  Ken Kikuchi ,  Masashi Gotoh ,  Takeshi Itoh ,  Takuo Kataho

    发明人： Takashi Satoh ,  Sadaki Satoh ,  Ken Kikuchi ,  Masashi Gotoh ,  Takeshi Itoh ,  Takuo Kataho

    IPC分类号： B22F3/00

    CPC分类号： B30B15/304 ,  B22F3/03 ,  B30B11/04

    摘要： A lower punch is arranged to be inserted into a cavity of a die from a lower side of the die. A upper punch is arranged to be inserted into the cavity from an upper side of the die to compact the powder filled in the cavity, in cooperation with the lower punch. A feeder supplies the powder into the cavity. A first cam driving system has a first cam for vertically moving the die relative to the lower punch. A second cam driving system has a second cam for vertically moving the upper punch. A third cam driving system has a third cam for moving the feeder forward or backward relative to the cavity. A contact member is connected to the first cam driving system. A stopper is located above or below the contact member and regulates relative vertical movement of the die with respect to the lower punch, in cooperation with the contact member. A fourth cam driving system has a fourth cam for vertically moving the stopper. The first cam, the second cam, the third cam, and the fourth cam are rotated in synchronism.

    摘要翻译： 下冲头布置成从模具的下侧插入模具的空腔中。 上冲头布置成从模具的上侧插入空腔中，以与下冲头配合来压实填充在空腔中的粉末。 馈线将粉末供应到空腔中。 第一凸轮驱动系统具有用于相对于下冲头垂直移动模具的第一凸轮。 第二凸轮驱动系统具有用于垂直移动上冲头的第二凸轮。 第三凸轮驱动系统具有用于相对于腔向前或向后移动进给器的第三凸轮。 接触构件连接到第一凸轮驱动系统。 塞子位于接触构件的上方或下方，并且与接触构件协调地调节模具相对于下冲头的相对垂直运动。 第四凸轮驱动系统具有用于垂直移动止动件的第四凸轮。 第一凸轮，第二凸轮，第三凸轮和第四凸轮同步旋转。

    Molding die unit
    4.
    发明授权
    Molding die unit 有权
    成型模具单元

    公开(公告)号：US07594809B2

    公开(公告)日：2009-09-29

    申请号：US11655068

    申请日：2007-01-19

    申请人： Sadaki Satoh ,  Masashi Gotoh ,  Ken Kikuchi ,  Takeshi Itoh ,  Takuo Kataho

    发明人： Sadaki Satoh ,  Masashi Gotoh ,  Ken Kikuchi ,  Takeshi Itoh ,  Takuo Kataho

    IPC分类号： B29C43/36

    CPC分类号： B22F3/03 ,  B29C43/361 ,  B29C2043/3618 ,  B29K2105/251

    摘要： A molding die unit has a shell and a die. The die is located inside the shell. A die hole is formed in the die. The die has first and second portions. The first and second portions include their respective surfaces defining the die hole and facing each other. A first through hole is formed in the shell and penetrates so as to open in an outside surface and in an inside surface of the shell. A second through hole continuing to the first through hole is formed at a position corresponding to the first through hole and in the first portion. The second through hole includes a first region and a second region. The first region opens in a surface of the first portion facing the inside surface of the shell and has a first sectional area. The second region opens in the surface defining the die hole and has a second sectional area smaller than the first sectional area.

    摘要翻译： 成型模具单元具有壳体和模具。 模具位于壳体内。 在模具中形成模孔。 模具具有第一和第二部分。 第一和第二部分包括它们各自的表面，其界定模具孔并面对彼此。 第一通孔形成在壳体中并穿透以在壳体的外表面和内表面中打开。 在与第一通孔相对应的位置和第一部分中形成有连续到第一通孔的第二通孔。 第二通孔包括第一区域和第二区域。 第一区域在面向壳体的内表面的第一部分的表面中开口并且具有第一截面积。 第二区域在限定模孔的表面中开口，并且具有小于第一截面积的第二截面面积。

    Method for cancer immunotherapy
    5.
    发明授权
    Method for cancer immunotherapy 有权
    癌症免疫治疗方法

    公开(公告)号：US08575308B2

    公开(公告)日：2013-11-05

    申请号：US13053996

    申请日：2011-03-22

    申请人： Toshio Nishihara ,  Masashi Gotoh

    发明人： Toshio Nishihara ,  Masashi Gotoh

    IPC分类号： A61K38/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K14/4748 ,  C07K16/44 ,  C07K2317/10

    摘要： A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group or the like; R3 is a hydrogen atom, alkyl group, amino group or the like; R4 is a hydrogen atom, alkyl group, carboxy group or the like; m is 1 or 2; and n is an integer of 0 to 2, with the proviso that when n is 0, R3 is a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof, and its use in cancer immunotherapy.

    摘要翻译： 式（1）的新化合物：其中X是酪氨酸残基或甲硫氨酸残基; Y和Z各自为单键等; R1是氢原子等; R2是羟基等; R3是氢原子，烷基，氨基等; R4是氢原子，烷基，羧基等; m为1或2; n为0〜2的整数，条件是当n为0时，R 3为氢原子或烷基，或其药学上可接受的盐及其在癌症免疫治疗中的用途。

    NOVEL PEPTIDE COMPOUND
    6.
    发明申请
    NOVEL PEPTIDE COMPOUND 有权
    新肽化合物

    公开(公告)号：US20100062010A1

    公开(公告)日：2010-03-11

    申请号：US12095418

    申请日：2006-11-29

    申请人： Toshio Nishihara ,  Masashi Gotoh

    发明人： Toshio Nishihara ,  Masashi Gotoh

    IPC分类号： A61K39/00 ,  C07K7/08 ,  C07K7/06 ,  C07K16/18 ,  C12N5/071 ,  A61K45/00 ,  A61P37/04 ,  A61P35/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K14/4748 ,  C07K16/44 ,  C07K2317/10

    摘要： A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group or the like; R3 is a hydrogen atom, alkyl group, amino group or the like; R4 is a hydrogen atom, alkyl group, carboxy group or the like; m is 1 or 2; and n is an integer of 0 to 2, with the proviso that when n is 0, R3 is a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof, and its use in cancer immunotherapy.

    摘要翻译： 式（1）的新化合物：其中X是酪氨酸残基或甲硫氨酸残基; Y和Z各自为单键等; R1是氢原子等; R2是羟基等; R3是氢原子，烷基，氨基等; R4是氢原子，烷基，羧基等; m为1或2; n为0〜2的整数，条件是当n为0时，R 3为氢原子或烷基，或其药学上可接受的盐及其在癌症免疫治疗中的用途。

    Lesion portion determining method of infrared observing system
    8.
    发明授权
    Lesion portion determining method of infrared observing system 有权
    红外观测系统病变部位确定方法

    公开(公告)号：US07530947B2

    公开(公告)日：2009-05-12

    申请号：US10856021

    申请日：2004-05-28

    申请人： Hiroyasu Yokomise ,  Yasumichi Yamamoto ,  Cheng-Long Huang ,  Eiichi Hayashi ,  Kotaro Kameyama ,  Dage Liu ,  Taku Okamoto ,  Masashi Gotoh

    发明人： Hiroyasu Yokomise ,  Yasumichi Yamamoto ,  Cheng-Long Huang ,  Eiichi Hayashi ,  Kotaro Kameyama ,  Dage Liu ,  Taku Okamoto ,  Masashi Gotoh

    IPC分类号： A61B1/06 ,  A61B6/00

    CPC分类号： A61B1/05 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/3132 ,  A61B90/50

    摘要： A lesion portion determining method of an infrared observing system includes at least an observing apparatus. The observing apparatus includes a light source device which radiates light of a first wavelength band including a wavelength of 805 nm and light of a second wavelength band including a wavelength longer than 805 nm, an image pick-up device which picks up an image of the first wavelength band and an image of the second wavelength band of an object irradiated by the light radiated from the light source device, display means which displays, as any color component of red, green, and blue, the image of the first wavelength band and the image of the second wavelength band that are picked-up by the image pick-up device. The lesion portion determining method includes a step of administering an infrared absorbing pigment to a patient, and a step of observing a visible range of the infrared absorbing pigment by the observing apparatus.

    摘要翻译： 一种红外观测系统的病变部分确定方法至少包括观察装置。 观察装置包括：辐射包括805nm波长的第一波长带的光和包括长于805nm的波长的第二波长带的光的光源装置;拾取图像的图像拾取装置， 第一波长带和由从光源装置照射的光照射的物体的第二波长带的图像，显​​示装置，其显示红色，绿色和蓝色的任何颜色分量，第一波长带的图像和 由图像拾取装置拾取的第二波长带的图像。 病变部分确定方法包括向患者施用红外线吸收颜料的步骤，以及通过观察装置观察红外线吸收颜料的可见范围的步骤。