公开(公告)号：US11622968B2

公开(公告)日：2023-04-11

申请号：US16838753

申请日：2020-04-02

申请人： Sagimet Biosciences Inc.

发明人： Douglas Buckley ,  Gregory Duke ,  Allan S. Wagman ,  Marc Evanchik ,  Robert S. McDowell

IPC分类号： A61K31/55 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/437 ,  A61K31/4525 ,  C07D491/048 ,  C07D401/14 ,  C07D491/10 ,  C07D413/10 ,  C07D401/06 ,  C07D405/04 ,  C07D487/04 ,  C07D413/14 ,  C07D491/107 ,  C07D401/04 ,  C07D405/14 ,  C07D405/10 ,  C07D405/12 ,  C07D471/04 ,  C07D401/12 ,  C07D491/052 ,  C07D401/10 ,  C07D513/04 ,  A61K31/453 ,  A61K31/451

摘要： Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).