公开(公告)号：US20130089542A1

公开(公告)日：2013-04-11

申请号：US13646589

申请日：2012-10-05

Applicant: Samsung Electronics Co. Ltd.

Inventor： Seung Hyun LEE ,  Kwang Ho CHEONG ,  Kyung Ah KIM ,  Ho Yeong SONG ,  Geun Woong KIM ,  Hye Won PARK ,  Young Mi OH ,  Saet Byoul LEE ,  Ji Min LEE ,  Yun Ju JEONG ,  Mi Young CHO ,  Jae Hyun CHOI ,  Yoon Aa CHOI

IPC: C07K16/40 ,  C07K7/08 ,  A61P35/02 ,  C12N15/63 ,  C12N5/10 ,  A61P35/00 ,  A61K39/395 ,  C12N15/13

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

Abstract: An anti c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject.

Abstract translation: 抗c-Met抗体或抗体片段及包含其的药物组合物，以及通过向受试者施用抗体来预防和治疗癌症的方法。

公开(公告)号：US20210269533A1

公开(公告)日：2021-09-02

申请号：US17193804

申请日：2021-03-05

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong KIM ,  Kyung Ah KIM ,  Hye Won PARK ,  Ho Yeong SONG ,  Young Mi OH ,  Saet Byoul LEE ,  Ji Min LEE ,  Kwang Ho CHEONG ,  Yun Ju JEONG ,  Mi Young CHO ,  Jae Hyun CHOI ,  Yun Jeong SONG ,  Yoon Aa CHOI

IPC: C07K16/28

Abstract: An anti-c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject are provided.

公开(公告)号：US20140212414A1

公开(公告)日：2014-07-31

申请号：US14167711

申请日：2014-01-29

Applicant: Samsung Electronics Co., Ltd.

Inventor： Young Mi OH ,  Kyung Ah Kim

IPC: A61K39/395 ,  A61K31/496 ,  C07K16/32

CPC classification number: A61K31/496 ,  A61K31/122 ,  A61K31/497 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2863 ,  A61K2300/00

Abstract: A method of preventing and/or treating a cancer comprising co-administering a p53 activator and a c-Met inhibitor to a patient in need thereof.

Abstract translation: 一种预防和/或治疗癌症的方法，包括将p53激活剂和c-Met抑制剂共同给予有需要的患者。

公开(公告)号：US20150017170A1

公开(公告)日：2015-01-15

申请号：US14327172

申请日：2014-07-09

Applicant: Samsung Electronics Co., Ltd.

Inventor： Young Mi OH ,  Kyung Ah Kim

IPC: C12Q1/37 ,  A61K45/06 ,  A61K39/395

CPC classification number: C12Q1/37 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/573 ,  G01N33/57446 ,  G01N2333/95 ,  G01N2500/04

Abstract: A method of selecting a subject for administration of an anti-c-Met antibody, comprising (i) determining the presence or the amount of a ubiquitin peptidase, (ii) determining the presence or expression level of a ubiquitin peptidase coding gene, or (iii) measuring the activity of a ubiquitin peptidase, in a biological sample; as well as related methods.

Abstract translation: 选择用于施用抗c-Met抗体的受试者的方法，包括（i）确定泛素肽酶的存在或量，（ii）确定泛素肽酶编码基因的存在或表达水平，或（ iii）测量生物样品中泛素肽酶的活性; 以及相关方法。

公开(公告)号：US20140105901A1

公开(公告)日：2014-04-17

申请号：US13949012

申请日：2013-07-23

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Ji Min LEE ,  Kyung Ah KIM ,  Bo Gyou KIM ,  Young Mi OH ,  Saet Byoul LEE ,  Yun Ju JEONG

IPC: G01N33/574 ,  C07K16/30 ,  C12Q1/68

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of identifying a cell sample or a subject suitable for treatment with an anti-c-Met antibody or antigen binding fragment thereof that specifically binds to an epitope within a SEMA domain of a c-Met protein by determining a Cbl concentration, a Cbl mutation, and/or a mutation of a site of c-Met for interaction with Cbl in a cell sample from a subject, as well as related compositions and methods.

Abstract translation: 一种鉴定细胞样本或适合于用抗c-Met抗体或其抗原结合片段治疗的受试者的方法，所述抗c-Met抗体或其抗原结合片段通过测定Cbl浓度特异性地结合c-Met蛋白质的SEMA结构域中的表位，Cbl 突变和/或与受试者的细胞样品中与Cbl相互作用的c-Met位点的突变，以及相关的组合物和方法。