公开(公告)号：US20130089542A1

公开(公告)日：2013-04-11

申请号：US13646589

申请日：2012-10-05

Applicant: Samsung Electronics Co. Ltd.

Inventor： Seung Hyun LEE ,  Kwang Ho CHEONG ,  Kyung Ah KIM ,  Ho Yeong SONG ,  Geun Woong KIM ,  Hye Won PARK ,  Young Mi OH ,  Saet Byoul LEE ,  Ji Min LEE ,  Yun Ju JEONG ,  Mi Young CHO ,  Jae Hyun CHOI ,  Yoon Aa CHOI

IPC: C07K16/40 ,  C07K7/08 ,  A61P35/02 ,  C12N15/63 ,  C12N5/10 ,  A61P35/00 ,  A61K39/395 ,  C12N15/13

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

Abstract: An anti c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject.

Abstract translation: 抗c-Met抗体或抗体片段及包含其的药物组合物，以及通过向受试者施用抗体来预防和治疗癌症的方法。

公开(公告)号：US20210269533A1

公开(公告)日：2021-09-02

申请号：US17193804

申请日：2021-03-05

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong KIM ,  Kyung Ah KIM ,  Hye Won PARK ,  Ho Yeong SONG ,  Young Mi OH ,  Saet Byoul LEE ,  Ji Min LEE ,  Kwang Ho CHEONG ,  Yun Ju JEONG ,  Mi Young CHO ,  Jae Hyun CHOI ,  Yun Jeong SONG ,  Yoon Aa CHOI

IPC: C07K16/28

Abstract: An anti-c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject are provided.

公开(公告)号：US20140086926A1

公开(公告)日：2014-03-27

申请号：US14025403

申请日：2013-09-12

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Ju JEONG ,  Kyung Ah KIM ,  Yun Jeong SONG ,  Ji Min LEE ,  Hyo Seon LEE ,  Jae Hyun CHOI ,  Saet Byoul LEE

IPC: A61K39/395 ,  A61K45/06

CPC classification number: A61K39/3955 ,  A61K45/06 ,  C07K16/2863 ,  C07K2317/24

Abstract: Provided is a method of combination therapy for prevention or treatment of c-Met-induced or angiogenesis factor-induced diseases including co-administering an angiogenesis inhibitor and an anti-c-Met antibody or an antigen-binding fragment thereof to a patient.

Abstract translation: 提供了用于预防或治疗c-Met诱导或血管生成因子诱导的疾病的组合疗法的方法，包括向患者共同给予血管生成抑制剂和抗c-Met抗体或其抗原结合片段。

公开(公告)号：US20140105901A1

公开(公告)日：2014-04-17

申请号：US13949012

申请日：2013-07-23

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Ji Min LEE ,  Kyung Ah KIM ,  Bo Gyou KIM ,  Young Mi OH ,  Saet Byoul LEE ,  Yun Ju JEONG

IPC: G01N33/574 ,  C07K16/30 ,  C12Q1/68

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of identifying a cell sample or a subject suitable for treatment with an anti-c-Met antibody or antigen binding fragment thereof that specifically binds to an epitope within a SEMA domain of a c-Met protein by determining a Cbl concentration, a Cbl mutation, and/or a mutation of a site of c-Met for interaction with Cbl in a cell sample from a subject, as well as related compositions and methods.

Abstract translation: 一种鉴定细胞样本或适合于用抗c-Met抗体或其抗原结合片段治疗的受试者的方法，所述抗c-Met抗体或其抗原结合片段通过测定Cbl浓度特异性地结合c-Met蛋白质的SEMA结构域中的表位，Cbl 突变和/或与受试者的细胞样品中与Cbl相互作用的c-Met位点的突变，以及相关的组合物和方法。

公开(公告)号：US20140302039A1

公开(公告)日：2014-10-09

申请号：US14244709

申请日：2014-04-03

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Ju JEONG ,  Kyung Ah Kim ,  Kyung Eun Kim ,  Chungho Kim

IPC: A61K39/395

CPC classification number: C07K16/2863 ,  A61K2039/507 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: A method for inhibiting angiogenesis and treating angiogenesis related diseases comprising administering an anti-c-Met antibody or an antigen-binding fragment thereof, and an anti-Ang-2 antibody or an antigen-binding fragment thereof, in combination simultaneously or sequentially; as well as related compositions and methods.

Abstract translation: 一种抑制血管生成和治疗血管发生相关疾病的方法，包括同时或依次给予抗c-Met抗体或其抗原结合片段，以及抗Ang-2抗体或其抗原结合片段; 以及相关的组合物和方法。

公开(公告)号：US20140294837A1

公开(公告)日：2014-10-02

申请号：US14228521

申请日：2014-03-28

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Yun Jeong SONG ,  Ho Yeong SONG ,  Seung Hyun LEE ,  Kyung Ah KIM ,  Yun Ju JEONG

IPC: C07K16/32 ,  C07K16/22

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K14/71 ,  C07K2317/10 ,  C07K2317/24 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: There are provided a fusion protein formed by coupling of anti-c-Met antibody and VEGF-binding fragment, a bispecific antibody comprising the fusion protein, a polynucleotide encoding the fusion protein, a transformant comprising the polynucleotide, a pharmaceutical composition comprising the bispecific antibody as an active ingredient, and a method for preparing the bispecific antibody which is targeted at c-Met and VEGF at the same time, with improved anticancer and anti-angiogenesis effects, comprising coupling an anti-c-Met antibody with a VEGF-binding fragment.

Abstract translation: 提供了通过偶联抗c-Met抗体和VEGF结合片段，包含融合蛋白的双特异性抗体，编码融合蛋白的多核苷酸，包含多核苷酸的转化体，包含双特异性抗体的药物组合物形成的融合蛋白 作为活性成分，以及同时制备靶向c-Met和VEGF的双特异性抗体的方法，具有改善的抗癌和抗血管生成作用，包括将抗c-Met抗体与VEGF结合偶联 分段。