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28 条记录 (耗时 0.025 秒)

    Tetrahydro-S-21-Br
    1.
    发明授权
    Tetrahydro-S-21-Br 失效
    四氢-S-21-Br

    公开(公告)号：US5239094A

    公开(公告)日：1993-08-24

    申请号：US683956

    申请日：1991-04-12

    申请人： Sandor Szabo ,  John L. Neumeyer ,  Philip LeQuesne

    发明人： Sandor Szabo ,  John L. Neumeyer ,  Philip LeQuesne

    IPC分类号： C07J7/00

    CPC分类号： C07J7/0085

    摘要： The invention is directed to novel angiotropic (angiogenic and angiostatic) steroids. They are halogenated in the 21 position. The invention is also directed to novel methods of treating gastrointestinal ulcers by the administration of the novel angiotropic (angiogenic) steroids.

    摘要翻译： 本发明涉及新颖的血管发生（血管生成和血管生成）类固醇。 它们在21位置被卤化。 本发明还涉及通过施用新型血管性（血管生成）类固醇治疗胃肠溃疡的新方法。

    Method of treating gastrointestinal ulcers with platelet derived growth factor
    2.
    发明授权
    Method of treating gastrointestinal ulcers with platelet derived growth factor 失效
    用血小板衍生生长因子治疗胃肠溃疡的方法

    公开(公告)号：US5234908A

    公开(公告)日：1993-08-10

    申请号：US866822

    申请日：1992-04-10

    申请人： Sandor Szabo ,  Marc F. Charette

    发明人： Sandor Szabo ,  Marc F. Charette

    IPC分类号： A61K38/18

    CPC分类号： A61K38/1858

    摘要： Disclosed is a method for treating ulcers of the gastrointestinal tract in a mammal which includes administering to the mammal a therapeutically effective amount of Platelet-Derived Growth Factor (PDGF) to the gastrointestinal tract of the mammal.

    摘要翻译： 公开了一种治疗哺乳动物胃肠道溃疡的方法，其包括向哺乳动物施用治疗有效量的血小板衍生生长因子（PDGF）给哺乳动物的胃肠道。

    Pivotable guard for shielding a needle
    4.
    发明授权
    Pivotable guard for shielding a needle 失效

    公开(公告)号：US06120482A

    公开(公告)日：2000-09-19

    申请号：US925974

    申请日：1997-09-09

    申请人： Sandor Szabo

    发明人： Sandor Szabo

    IPC分类号： A61M5/32

    CPC分类号： A61M5/3216 ,  Y10S128/919

    摘要： A needle guard assembly is provided for mounting to the hub of a needle assembly. The needle guard assembly includes a guide that is engageable on the hub. An elongate U-shaped cover is hingedly mounted to the guide and can be rotated from a first position where the needle cannula is substantially surrounded by the U-shaped walls of the cover into a second position where the needle cannula is exposed for use. The needle guard assembly further includes a slide that is slidably engaged in the guide and movable from a first position where the slide cooperatively engages the cover for completely surrounding the needle cannula to a second position where the slide is spaced proximally from the cover, thereby permitting the cover to rotate into its second position.

    Safety needle assembly having telescoping shield
    5.
    发明授权
    Safety needle assembly having telescoping shield 失效
    具有伸缩屏蔽的安全针组件

    公开(公告)号：US5746727A

    公开(公告)日：1998-05-05

    申请号：US772237

    申请日：1996-12-23

    申请人： Arlinda Graves ,  Sandor Szabo

    发明人： Arlinda Graves ,  Sandor Szabo

    IPC分类号： A61M5/32 ,  A61M25/06 ,  A61M25/00

    CPC分类号： A61M25/0631 ,  A61M5/3271

    摘要： A safety needle assembly for an intravenous fitting which protects against inadvertent touch contact with a piercing element after use. The assembly includes a piercing element such as a sharpened needle cannula or a blunt ended cannula that is mounted within a carrier member. A protective shield component is provided which is axially slidable relative to the carrier member and configured to attach to an intravenous fitting. The protective shield and carrier member may feature a guide assembly for guiding the shield between a pre-use, injection position and a post-use, locked position wherein inadvertent touch contact with the distal end of the piercing element is avoided. A releasable locking assembly may also be incorporated to releasably retain the protective shield in its pre-use position so as to facilitate attachment of the safety needle assembly with the intravenous fitting.

    摘要翻译： 一种用于静脉接头的安全针组件，其在使用后防止与穿刺元件的无意的触摸接触。 组件包括穿刺元件，例如尖锐的针插管或安装在承载构件内的平头端套管。 提供保护屏蔽部件，其可相对于承载部件轴向滑动并且构造成附接到静脉内配件。 保护屏蔽和承载构件可以具有导向组件，用于在预先使用的注射位置和使用后的锁定位置之间引导护罩，其中避免了与穿刺元件的远端的无意的触摸接触。 还可以结合可释放的锁定组件以将保护罩可释放地保持在其预先使用位置，以便于安全针组件与静脉内配件的连接。

    Locking safety needle assembly
    6.
    发明授权
    Locking safety needle assembly 失效
    锁定安全针组件

    公开(公告)号：US5496274A

    公开(公告)日：1996-03-05

    申请号：US297347

    申请日：1994-08-29

    申请人： Arlinda Graves ,  Niall Sweeney ,  Sandor Szabo

    发明人： Arlinda Graves ,  Niall Sweeney ,  Sandor Szabo

    IPC分类号： A61M39/02 ,  A61M39/00 ,  A61M39/10 ,  A61M39/14 ,  A61M37/00 ,  A61M5/00 ,  A61M5/32

    CPC分类号： A61M39/1011 ,  A61M39/14 ,  A61M2039/1027 ,  A61M2039/1044 ,  A61M2039/1066 ,  A61M2039/1072

    摘要： A safety needle assembly for providing secure connection of a needle cannula to a straight-site or Y-site of an intravenous fitting. The assembly includes a base portion and a protective shield disposed about the needle cannula to at least partially envelop the needle cannula within the shield. A latch is pivoted to the shield so as to releasably lock the intravenous fitting within the shield. The latch includes a pivot arm having at least one shield engaging finger member disposed to biasingly engage at least a portion of the shield, and at least one member disposed through a passageway formed in the shield to trap the intravenous fitting within the shield.

    摘要翻译： 一种安全针组件，用于提供针插管与静脉内配件的直线位置或Y位置的牢固连接。 该组件包括基部和围绕针插管设置的至少部分地将护套内的针插管包封的保护屏蔽。 闩锁枢转到屏蔽件，以便将静脉内配件可释放地锁定在屏蔽内。 闩锁包括枢转臂，枢转臂具有设置成偏置地接合屏蔽件的至少一部分的至少一个屏蔽接合指状构件，以及设置成穿过形成在屏蔽件中的通道的至少一个构件，以将静脉插管收纳在屏蔽内。

    Pyrazole and thiozole derivatives for treatment of gastrointestinal ulcer disease
    7.
    发明授权
    Pyrazole and thiozole derivatives for treatment of gastrointestinal ulcer disease 失效
    用于治疗胃肠疾病的吡唑和噻唑衍生物

    公开(公告)号：US5223521A

    公开(公告)日：1993-06-29

    申请号：US666391

    申请日：1991-03-08

    申请人： Sandor Szabo

    发明人： Sandor Szabo

    IPC分类号： A61K31/415 ,  A61K31/425 ,  A61K31/56 ,  A61K31/57

    CPC分类号： A61K31/56 ,  A61K31/415 ,  A61K31/425 ,  A61K31/57 ,  A61K31/60 ,  Y10S514/926 ,  Y10S514/927

    摘要： The invention relates to a method of preventing or treating gastrointestinal ulcer disease and microvascular injury in a mammal comprising administering to said mammal a pyrazole derivative alone or in combination with an ulcerogenic agent. The invention further relates to pharmaceutical compositions comprising a pyrazole derivative in combination with an ulcerogenic therapeutic agent to inhibit or prevent the ulcerogenic effect of that agent.

    摘要翻译： 本发明涉及一种预防或治疗哺乳动物的胃肠溃疡疾病和微血管损伤的方法，包括向所述哺乳动物施用单独的或与溃疡发生剂组合的吡唑衍生物。 本发明还涉及药物组合物，其包含与溃疡性治疗剂组合的吡唑衍生物，以抑制或预防该药物的溃疡形成作用。

    Method for producing an animal model for inflammatory bowel disease including ulcerative colitis
    8.
    发明授权
    Method for producing an animal model for inflammatory bowel disease including ulcerative colitis 失效
    用于产生包括溃疡性结肠炎的炎症性肠病动物模型的方法

    公开(公告)号：US5214066A

    公开(公告)日：1993-05-25

    申请号：US510229

    申请日：1990-04-18

    申请人： Sandor Szabo

    发明人： Sandor Szabo

    IPC分类号： A61K31/16 ,  A61K31/19 ,  A61K31/40

    CPC分类号： A61K31/16 ,  A61K31/19 ,  A61K31/40

    摘要： A new animal model for Inflammatory Bowel Disease, including idiopathic ulcerative colitis and Chron's disease, as well as methods for problems such as an animal, is provided. Chronic ulcerative condition is induced by topical administration of a sulfhydryl blocker, such as N-ethylmaleimide or iodoacetamide, to the colon. The new animal model is useful for studying the pathogenesis of chronic ulcerative disease, and prevention and treatment thereof, and for evaluating drugs suspected of being useful in the treatment of same.

    摘要翻译： 提供了一种新型的炎性肠病动物模型，包括特发性溃疡性结肠炎和Chron氏病，以及诸如动物等问题的方法。 通过向结肠局部施用巯基封闭剂如N-乙基马来酰亚胺或碘乙酰胺诱导慢性溃疡性病症。 新型动物模型可用于研究慢性溃疡性疾病及其预防和治疗的发病机制，并用于评估疑似在治疗中有用的药物。

    Stereophonic microphone system
    10.
    发明授权
    Stereophonic microphone system 失效
    立体声麦克风系统

    公开(公告)号：US5073936A

    公开(公告)日：1991-12-17

    申请号：US449298

    申请日：1989-12-05

    申请人： Rudolf Gorike ,  Fritz Sippl ,  Sandor Szabo

    发明人： Rudolf Gorike ,  Fritz Sippl ,  Sandor Szabo

    IPC分类号： H04R1/08 ,  H04R5/027 ,  H04S1/00

    CPC分类号： H04R5/027 ,  H04R1/08 ,  H04S1/00

    摘要： A stereophonic microphone system for improving stereophonic hearing utilizes intensity stereophonic and/or time difference stereophonic pickup methods with the use of replicas of the human head. The microphones are mounted in the replicas of the outer auditory meatus. The replica of the human head is limited to replicas of the pinna with outer auditory meatus. In addition to the known stereophonic recording device used as a position association stage, two replicas of human pinnas are used, with pressure microphones in each opening of the auditory meatus as a shape association stage. The pinna replicas are arranged spaced apart and oriented on the human head or closely next to each other with the same orientation. The pinna replicas are arranged preferably immediately adjacent the arrangement of known directional microphones for the interaural sound recording in the horizontal and median planes. As a result, in addition to the proven technology of intensity and/or delay stereophonics in the frequency range below approximately 1500 Hz, interaural resonances become effective in the horizontal and vertical plane through the pinna replicas in the frequency range above approximately 1500 HZ. It is significant that here signals are created which are as incoherent as possible in order to avoid, particularly in head set reproduction, a localization in the head or the proximity effect at the ears.

    摘要翻译： 用于改善立体声听觉的立体声麦克风系统利用使用人头复制品的强度立体声和/或时差立体声拾取方法。 麦克风安装在外耳道的副本中。 人头部的复制品仅限于具有外耳道的针刺复制品。 除了用作位置关联阶段的已知立体声记录装置之外，还使用两个人类针尖复制品，其中在听觉口的每个开口中的压力麦克风作为形状关联阶段。 针刺复制品间隔开并定向在人的头部上或者以相同的方向彼此靠近。 耳针复制品优选地被布置成紧邻已知的定向麦克风的布置，用于水平和中间平面中的耳间声音记录。 结果，除了在低于大约1500Hz的频率范围内的经过验证的强度和/或延迟立体声技术的技术之外，在大约1500HZ以上的频率范围内，经由pinna复制品的水平和垂直平面中的ural共振变得有效。 重要的是，这些信号被创建为尽可能不相干，以避免，特别是在头戴式再现中头部的定位或耳朵的接近效应。