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公开(公告)号：US08017760B2
公开(公告)日：2011-09-13
申请号：US12046421
申请日：2008-03-11
申请人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madeline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madeline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US20090124009A1
公开(公告)日：2009-05-14
申请号：US12046421
申请日：2008-03-11
申请人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
IPC分类号： C12N5/08 , C07H21/04 , A61K31/711
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US08853178B2
公开(公告)日：2014-10-07
申请号：US13177462
申请日：2011-07-06
申请人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US20120077862A1
公开(公告)日：2012-03-29
申请号：US13177462
申请日：2011-07-06
申请人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US07563884B2
公开(公告)日：2009-07-21
申请号：US11008747
申请日：2004-12-09
申请人： Lex M. Cowsert , Jacqueline R. Wyatt , Susan M. Freier , Brett P. Monia , Madeline M. Butler , Robert McKay
发明人： Lex M. Cowsert , Jacqueline R. Wyatt , Susan M. Freier , Brett P. Monia , Madeline M. Butler , Robert McKay
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US06602857B1
公开(公告)日：2003-08-05
申请号：US09629644
申请日：2000-07-31
IPC分类号： A61K3828
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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7.发明授权公开(公告)号：US06210892B1
公开(公告)日：2001-04-03
申请号：US09277020
申请日：1999-03-26
申请人： C. Frank Bennett , Stanley T. Cooke , Muthiah Manoharan , Jacqueline R. Wyatt , Brenda F. Baker , Brett P. Monia , Susan M. Freier , Robert McKay , James G. Karras
发明人： C. Frank Bennett , Stanley T. Cooke , Muthiah Manoharan , Jacqueline R. Wyatt , Brenda F. Baker , Brett P. Monia , Susan M. Freier , Robert McKay , James G. Karras
IPC分类号： C12Q168
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： The present invention provides compositions and methods for controlling the behavior of a cell, tissue or organism through antisense modulation of mRNA processing, using antisense compounds which does not support cleavage of the mRNA target.
摘要翻译： 本发明提供了使用不支持mRNA靶的切割的反义化合物来控制细胞，组织或生物体通过mRNA加工反义调节的行为的组合物和方法。
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公开(公告)号：US20100222412A1
公开(公告)日：2010-09-02
申请号：US12687533
申请日：2010-01-14
申请人： Brett P. Monia , Robert McKay , Susan M. Freier , Sanjay Bhanot , Lynnetta Watts
发明人： Brett P. Monia , Robert McKay , Susan M. Freier , Sanjay Bhanot , Lynnetta Watts
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for treatment of diseases are provided.
摘要翻译： 提供化合物，组合物和方法用于调节糖皮质激素受体的表达。 组合物包含靶向编码糖皮质激素受体的核酸的反义化合物，特别是具有特定体内特性的反义寡核苷酸。 提供了使用这些化合物调节糖皮质激素受体表达和治疗疾病的方法。
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公开(公告)号：US08299041B2
公开(公告)日：2012-10-30
申请号：US11910606
申请日：2006-04-10
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A61K31/202 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3521
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of ACC1 or ACC2 or both in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于在细胞，组织或动物中调节ACC1或ACC2或两者的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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10.发明申请公开(公告)号：US20130109849A1
公开(公告)日：2013-05-02
申请号：US13619362
申请日：2012-09-14
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , A61K31/202 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3521
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of ACC1 or ACC2 or both in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于在细胞，组织或动物中调节ACC1或ACC2或两者的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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