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19 条记录 (耗时 0.044 秒)

    System of components for preparing oligonucleotides
    7.
    发明授权
    System of components for preparing oligonucleotides 失效
    制备寡核苷酸的组分体系

    公开(公告)号：US07321828B2

    公开(公告)日：2008-01-22

    申请号：US09067638

    申请日：1998-04-28

    申请人： Lex M. Cowsert ,  Brenda F. Baker ,  John McNeil ,  Susan M. Freier ,  Henri M. Sasmor ,  Douglas G. Brooks ,  Cara Ohashi ,  Jacqueline R. Wyatt ,  Alexander H. Borchers ,  Timothy A. Vickers

    发明人： Lex M. Cowsert ,  Brenda F. Baker ,  John McNeil ,  Susan M. Freier ,  Henri M. Sasmor ,  Douglas G. Brooks ,  Cara Ohashi ,  Jacqueline R. Wyatt ,  Alexander H. Borchers ,  Timothy A. Vickers

    IPC分类号： C12P19/34 ,  G06F19/00 ,  C12Q1/68

    CPC分类号： C12Q1/6811 ,  B01J2219/007 ,  C12N15/1048 ,  C40B50/02 ,  G06F19/18 ,  G06F19/22

    摘要： Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.

    摘要翻译： 提供了用于产生具有期望的物理，化学和/或生物活性的合成化合物（即活性化合物）的相互优选的基于计算机的迭代方法。 在该过程的迭代过程中，提供或选择靶核酸序列，并且根据确定的标准以计算机生成候选核碱基序列的文库。 选择“虚拟”寡核苷酸化学，并产生具有选定的核碱基序列的虚拟寡核苷酸化合物文库。 审查这些虚拟化合物，并选择预测具有特定性质的化合物。 所选择的化合物是机械合成的，并且优选机械地测定所需的物理，化学或生物活性。 因此产生活性化合物，并且同时确定适用于寡核苷酸或基于序列的调节的靶核酸的优选序列和区域。

    Methods of obtaining active antisense compounds
    8.
    发明授权
    Methods of obtaining active antisense compounds 有权
    获得活性反义化合物的方法

    公开(公告)号：US07592440B2

    公开(公告)日：2009-09-22

    申请号：US10686317

    申请日：2003-10-15

    申请人： Susan M. Freier ,  Olga Matveeva ,  Alexander Tsodikov ,  Michael C. Giddings ,  Jacqueline R. Wyatt

    发明人： Susan M. Freier ,  Olga Matveeva ,  Alexander Tsodikov ,  Michael C. Giddings ,  Jacqueline R. Wyatt

    IPC分类号： C07H21/04 ,  C07H21/00 ,  C40B30/02 ,  C40B30/10 ,  C40B40/06

    CPC分类号： C12N15/113 ,  C07H21/00 ,  C12Q1/6811

    摘要： Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.

    摘要翻译： 提供了获得具有针对所需靶标的活性的反义寡核苷酸的方法。 提供了鉴定预测反义寡核苷酸活性的寡核苷酸序列基序的方法，以及根据该方法鉴定的基序。 提供了选择有效的反义寡核苷酸序列和有效的反义靶序列的方法，以及根据这些方法选择的序列。 在本发明的其它方法中，设计寡核苷酸与含有一种或多种活性增强基序的靶序列杂交。 还提供了根据这些方法设计的反义寡核苷酸。

    METHODS OF OBTAINING ACTIVE ANTISENSE COMPOUNDS
    9.
    发明申请
    METHODS OF OBTAINING ACTIVE ANTISENSE COMPOUNDS 有权
    获得活性抗体化合物的方法

    公开(公告)号：US20100113292A1

    公开(公告)日：2010-05-06

    申请号：US12557358

    申请日：2009-09-10

    申请人： Susan M. Freier ,  Olga Matveeva ,  Alexander Tsodikov ,  Michael C. Giddings ,  Jacqueline R. Wyatt

    发明人： Susan M. Freier ,  Olga Matveeva ,  Alexander Tsodikov ,  Michael C. Giddings ,  Jacqueline R. Wyatt

    IPC分类号： C40B30/02 ,  C40B50/02

    CPC分类号： C12N15/113 ,  C07H21/00 ,  C12Q1/6811

    摘要： Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.

    摘要翻译： 提供了获得具有针对所需靶标的活性的反义寡核苷酸的方法。 提供了鉴定预测反义寡核苷酸活性的寡核苷酸序列基序的方法，以及根据该方法鉴定的基序。 提供了选择有效的反义寡核苷酸序列和有效的反义靶序列的方法，以及根据这些方法选择的序列。 在本发明的其它方法中，设计寡核苷酸与含有一种或多种活性增强基序的靶序列杂交。 还提供了根据这些方法设计的反义寡核苷酸。

    Methods of obtaining active antisense compounds
    10.
    发明授权
    Methods of obtaining active antisense compounds 有权
    获得活性反义化合物的方法

    公开(公告)号：US08202982B2

    公开(公告)日：2012-06-19

    申请号：US12557358

    申请日：2009-09-10

    申请人： Susan M. Freier ,  Olga Matveeva ,  Alexander Tsodikov ,  Michael C. Giddings ,  Jacqueline R. Wyatt

    发明人： Susan M. Freier ,  Olga Matveeva ,  Alexander Tsodikov ,  Michael C. Giddings ,  Jacqueline R. Wyatt

    IPC分类号： C07H21/00 ,  C07H21/04 ,  A61K31/70

    CPC分类号： C12N15/113 ,  C07H21/00 ,  C12Q1/6811

    摘要： Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense oligonucleotide activity are provided, as are motifs identified according to this method. Methods of selecting effective antisense oligonucleotide sequences and effective antisense target sequences are provided, as are sequences selected according to these methods. In other methods of the invention, oligonucleotides are designed to hybridize to target sequences containing one or more activity-enhancing motifs. Antisense oligonucleotides designed according to these methods are also provided.

    摘要翻译： 提供了获得具有针对所需靶标的活性的反义寡核苷酸的方法。 提供了鉴定预测反义寡核苷酸活性的寡核苷酸序列基序的方法，以及根据该方法鉴定的基序。 提供了选择有效的反义寡核苷酸序列和有效的反义靶序列的方法，以及根据这些方法选择的序列。 在本发明的其它方法中，设计寡核苷酸与含有一种或多种活性增强基序的靶序列杂交。 还提供了根据这些方法设计的反义寡核苷酸。