专利检索 ap:("Sapporo Medical University") AND inv:"Kozue Kamiya" 第 1 页

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发明申请
METHOD FOR PRODUCING MESENCHYMAL STEM CELLS, THERAPEUTIC EFFECT MARKER OF MESENCHYMAL STEM CELLS, METHOD FOR DETERMINING THERAPEUTIC EFFECTS OF MESENCHYMAL STEM CELLS, AND CELLULAR PREPARATION CONTAINING MESENCHYMAL STEM CELLS 有权

公开(公告)号：US20220348864A1

公开(公告)日：2022-11-03

申请号：US17836294

申请日：2022-06-09

申请人： Sapporo Medical University

发明人： Takako Chikenji , Mineko Fujimiya , Yuki Saito , Masako Nakano , Miho Otani , Yuka Mizue , Takashi Matsumura , Kozue Kamiya

IPC分类号： C12N5/00 , A61K35/28 , C12N5/0775 , C12Q1/6881 , G01N33/569

摘要： [Problem] To provide a cell preparation including mesenchymal stem cells (MSCs) having a high therapeutic effect. [Solution] A method for producing activated mesenchymal stem cells, including a step of culturing MSCs in a medium containing an activator that includes an extract from a mammalian fetal appendage as an active ingredient, using a cell culture carrier having a three-dimensional structure formed of a fiber is provided. A marker for a therapeutic effect of MSCs selected from the group consisting of p16ink4a, p14ARF, CDK4, CDK6, RB, and CD47, a method for determining a therapeutic effect using the marker, a method for determining suitability of MSCs to be treated with a treatment for enhancing a therapeutic effect of MSCs, a cell preparation including MSCs, and a method for producing the same are also provided.