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公开(公告)号:US20190117751A1
公开(公告)日:2019-04-25
申请号:US16065488
申请日:2016-12-27
IPC分类号: A61K39/00 , A61K35/17 , C07K16/30 , A61P35/00 , A61K31/713 , C07K14/705 , C12N15/113 , C12N5/12 , G01N33/574 , A61K39/39
摘要: The object of the present invention is to provide a detecting agent for specifically detecting a tumor cell, a tumor antigen peptide-specifically presented on a tumor cell, a pharmaceutical composition useful for the prevention and/or treatment of cancer, the pharmaceutical composition containing the tumor antigen peptide as an active ingredient, etc. The above object has been achieved by a tumor antigen peptide or its motif-substituted product, the tumor antigen peptide comprising 8 to 14 consecutive amino acids in an amino acid sequence of a protein encoded by a gene selected from the group consisting of PVT1, SUV39H2, ZNF724P, SNRNP40, and DYRK4, the tumor antigen peptide having an HLA binding ability.
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公开(公告)号:US20170360911A1
公开(公告)日:2017-12-21
申请号:US15534315
申请日:2015-12-08
发明人: Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Sho Miyamoto , Vitaly Kochin , Masashi Goto
IPC分类号: A61K39/00 , C07K7/06 , G01N33/574 , C07K16/30 , C12N5/0783 , G01N33/50 , C12Q1/68 , C07K16/28
摘要: The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
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公开(公告)号:US20160310583A1
公开(公告)日:2016-10-27
申请号:US15026412
申请日:2014-10-03
发明人: Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Vitaly Kochin , Akari Takaya , Masashi Goto
IPC分类号: A61K39/00 , C07K16/30 , A61K39/39 , C12N5/0783 , C07K16/28 , C07K14/705 , C12Q1/68 , C07K14/47 , C07K14/74
CPC分类号: A61K39/0011 , A61K31/7088 , A61K38/00 , A61K39/39 , A61K2039/5158 , A61K2039/572 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/70539 , C07K16/2833 , C07K16/30 , C07K16/3046 , C12N5/0638 , C12N15/09 , C12Q1/02 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/574 , A61K2300/00
摘要: The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO—XO—ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs.
摘要翻译: 本发明的目的是提供:用于特异性检测癌症干细胞的检测剂; 癌干细胞特异性表达的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物,其含有作为其有效成分的药物组合物; 以及筛选所述肿瘤抗原肽的方法。 由YO-XO-ZO表示的肽,包括至少一种所述肽作为表位肽并且连接有多个表位肽的多表位肽,编码至少肽或多表面肽的多核苷酸,药物组合物 含有它们作为其有效成分,以及特征在诱导CTL的癌症预防和/或治疗剂。
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公开(公告)号:US10765729B2
公开(公告)日:2020-09-08
申请号:US15534315
申请日:2015-12-08
发明人: Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Sho Miyamoto , Vitaly Kochin , Masashi Goto
IPC分类号: A61K38/00 , A61K39/00 , C07K16/30 , A61K48/00 , C12Q1/68 , G01N33/50 , G01N33/574 , A61P35/00 , C07K14/47 , C07K7/06 , C07K16/28 , C12N5/0783 , C12Q1/6886
摘要: The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
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公开(公告)号:US20180147270A9
公开(公告)日:2018-05-31
申请号:US15534315
申请日:2015-12-08
发明人: Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Sho Miyamoto , Vitaly Kochin , Masashi Goto
IPC分类号: A61K39/00 , C12Q1/68 , C07K7/06 , C07K16/28 , C07K16/30 , C12N5/0783 , G01N33/50 , G01N33/574
摘要: The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
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