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公开(公告)号：US20170360911A1
公开(公告)日：2017-12-21
申请号：US15534315
申请日：2015-12-08
发明人： Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Sho Miyamoto , Vitaly Kochin , Masashi Goto
IPC分类号： A61K39/00 , C07K7/06 , G01N33/574 , C07K16/30 , C12N5/0783 , G01N33/50 , C12Q1/68 , C07K16/28
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
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公开(公告)号：US10765729B2
公开(公告)日：2020-09-08
申请号：US15534315
申请日：2015-12-08
发明人： Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Sho Miyamoto , Vitaly Kochin , Masashi Goto
IPC分类号： A61K38/00 , A61K39/00 , C07K16/30 , A61K48/00 , C12Q1/68 , G01N33/50 , G01N33/574 , A61P35/00 , C07K14/47 , C07K7/06 , C07K16/28 , C12N5/0783 , C12Q1/6886
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
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公开(公告)号：US20160367628A1
公开(公告)日：2016-12-22
申请号：US15162833
申请日：2016-05-24
发明人： Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号： A61K38/17 , C12Q1/68 , G01N33/574
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
摘要翻译： 用于检测作为感兴趣的受试者的细胞块中的癌干细胞的分子标记，其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记，但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒，其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。
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公开(公告)号：US20160310583A1
公开(公告)日：2016-10-27
申请号：US15026412
申请日：2014-10-03
发明人： Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Vitaly Kochin , Akari Takaya , Masashi Goto
IPC分类号： A61K39/00 , C07K16/30 , A61K39/39 , C12N5/0783 , C07K16/28 , C07K14/705 , C12Q1/68 , C07K14/47 , C07K14/74
CPC分类号： A61K39/0011 , A61K31/7088 , A61K38/00 , A61K39/39 , A61K2039/5158 , A61K2039/572 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/70539 , C07K16/2833 , C07K16/30 , C07K16/3046 , C12N5/0638 , C12N15/09 , C12Q1/02 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/574 , A61K2300/00
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting cancer stem cells; a tumor antigen peptide specifically exhibited by cancer stem cells; a pharmaceutical composition for the prevention and/or treatment of cancer, containing same as an effective component thereof; and a method for screening said tumor antigen peptide. A peptide indicated by YO—XO—ZO, a polyepitope peptide including at least one said peptide as an epitope peptide and having a plurality of epitope peptides joined therein, a polynucleotide that codes at least either the peptide or the polyepitope peptide, a pharmaceutical composition containing these as an effective component thereof, and a cancer prevention and/or treatment agent characterized by inducing CTLs.
摘要翻译： 本发明的目的是提供：用于特异性检测癌症干细胞的检测剂; 癌干细胞特异性表达的肿瘤抗原肽; 用于预防和/或治疗癌症的药物组合物，其含有作为其有效成分的药物组合物; 以及筛选所述肿瘤抗原肽的方法。 由YO-XO-ZO表示的肽，包括至少一种所述肽作为表位肽并且连接有多个表位肽的多表位肽，编码至少肽或多表面肽的多核苷酸，药物组合物 含有它们作为其有效成分，以及特征在诱导CTL的癌症预防和/或治疗剂。
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公开(公告)号：US20160166666A1
公开(公告)日：2016-06-16
申请号：US14904525
申请日：2014-07-11
发明人： Keiki Masuda , Haruhisa Iguchi , Masashi Goto , Toshihiko Torigoe , Yoshihiko Hirohashi , Rena Morita
IPC分类号： A61K39/00 , C07K16/28 , C07K14/74 , C07K14/705 , A61K38/17
CPC分类号： A61K39/0011 , A61K38/177 , A61K2039/55566 , A61K2039/57 , C07K14/4747 , C07K14/705 , C07K14/70539 , C07K16/2833 , C07K16/30 , C07K2317/32
摘要： Provided is a tumor antigen peptide and the like that is useful in the prevention and/or treatment of cancer. The present invention pertains to: a peptide comprising the amino acid sequence of sequence number 3, sequence number 4, sequence number 5, sequence number 6, or sequence number 11; a polyepitope peptide resulting from joining a plurality of epitope peptides and containing at least one of the aforementioned peptides as one epitope peptide; a polynucleotide coding for at least one of the polyepitope peptides or the peptides; a pharmaceutical composition containing the above as active ingredients; a cancer prevention and/or treatment agent characterized by inducing CTLs; and the like.
摘要翻译： 提供可用于预防和/或治疗癌症的肿瘤抗原肽等。 本发明涉及：包含序列号3，序列号4，序列号5，序列号6或序列号11的氨基酸序列的肽; 通过连接多个表位肽并含有至少一个前述肽作为一个表位肽而产生的多表位肽; 编码至少一种多表位肽或多肽的多核苷酸; 含有上述作为活性成分的药物组合物; 特征在于诱导CTL的癌症预防和/或治疗剂; 等等。
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公开(公告)号：US20190054141A1
公开(公告)日：2019-02-21
申请号：US16110001
申请日：2018-08-23
发明人： Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号： A61K38/17 , C12N15/113 , C12N5/0783 , C07K7/06 , G01N33/574 , G01N33/50 , C12Q1/6886
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号：US10080776B2
公开(公告)日：2018-09-25
申请号：US15162833
申请日：2016-05-24
发明人： Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号： A61K38/17 , C12N15/113 , C12Q1/6886 , G01N33/50 , G01N33/574 , C07K7/06 , C12N5/0783
CPC分类号： A61K38/177 , C07K7/06 , C12N5/0638 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N33/574 , G01N33/57492 , G01N2333/705
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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公开(公告)号：US20180147270A9
公开(公告)日：2018-05-31
申请号：US15534315
申请日：2015-12-08
发明人： Noriyuki Sato , Toshihiko Torigoe , Yoshihiko Hirohashi , Takayuki Kanaseki , Sho Miyamoto , Vitaly Kochin , Masashi Goto
IPC分类号： A61K39/00 , C12Q1/68 , C07K7/06 , C07K16/28 , C07K16/30 , C12N5/0783 , G01N33/50 , G01N33/574
摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.
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公开(公告)号：US20190117751A1
公开(公告)日：2019-04-25
申请号：US16065488
申请日：2016-12-27
IPC分类号： A61K39/00 , A61K35/17 , C07K16/30 , A61P35/00 , A61K31/713 , C07K14/705 , C12N15/113 , C12N5/12 , G01N33/574 , A61K39/39
摘要： The object of the present invention is to provide a detecting agent for specifically detecting a tumor cell, a tumor antigen peptide-specifically presented on a tumor cell, a pharmaceutical composition useful for the prevention and/or treatment of cancer, the pharmaceutical composition containing the tumor antigen peptide as an active ingredient, etc. The above object has been achieved by a tumor antigen peptide or its motif-substituted product, the tumor antigen peptide comprising 8 to 14 consecutive amino acids in an amino acid sequence of a protein encoded by a gene selected from the group consisting of PVT1, SUV39H2, ZNF724P, SNRNP40, and DYRK4, the tumor antigen peptide having an HLA binding ability.
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公开(公告)号：US11382952B2
公开(公告)日：2022-07-12
申请号：US16110001
申请日：2018-08-23
发明人： Toshihiko Torigoe , Yoshihiko Hirohashi , Noriyuki Satoh , Kenjiro Kamiguchi , Rena Morita , Satoshi Nishizawa , Akari Takahashi
IPC分类号： A61K39/00 , A61K38/17 , C12N15/113 , C12Q1/6886 , G01N33/50 , G01N33/574 , C07K7/06 , C12N5/0783
摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.
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