利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

19 条记录 (耗时 0.01 秒)

    Method and test composition for the determination of the substrate for xanthine oxidase
    5.
    发明授权
    Method and test composition for the determination of the substrate for xanthine oxidase 失效
    用于黄嘌呤氧化酶底物测定的方法和试验组合物

    公开(公告)号：US4341868A

    公开(公告)日：1982-07-27

    申请号：US201067

    申请日：1980-04-18

    申请人： Toru Nakanishi ,  Yozo Machida

    发明人： Toru Nakanishi ,  Yozo Machida

    IPC分类号： C12N9/04 ,  C12Q1/26 ,  C12N9/06 ,  C12R1/01

    CPC分类号： C12N9/0006 ,  C12Q1/26 ,  C12Y117/03002

    摘要： The substrate for xanthine oxidase such as xanthine, hypoxanthine, guanine, 2-hydroxypurine, etc. are determined by oxidizing the substrate by the action of xanthine oxidase derived from a microorganism and determining the formed hydrogen peroxide by the system for the determination of hydrogen peroxide comprising peroxidase and coloring reagent.The determination is carried out in one step by using the test composition for the determination of the substrate for xanthine oxidase which comprises xanthine oxidase and a system for the determination of hydrogen peroxide.The determination method can be applied to the determination of the compound which participates in the system wherein the substrate is stoichiometrically formed by the reaction or decomposition. When the system is an enzymatic reaction, the compound is determined in one step.Xanthine oxidase used in the present invention is different from known xanthine oxidase in molecular weight and is prepared by culturing a microorganism belonging to the genus Enterobacter.

    摘要翻译： 黄嘌呤氧化酶如黄嘌呤，次黄嘌呤，鸟嘌呤，2-羟基嘌呤等的底物是通过用衍生自微生物的黄嘌呤氧化酶的作用氧化底物来测定的，并通过用于测定过氧化氢的系统测定形成的过氧化氢 包括过氧化物酶和着色剂。 通过使用包含黄嘌呤氧化酶的黄嘌呤氧化酶底物的测定用试剂和测定过氧化氢的体系，一步进行测定。 该测定方法可以应用于通过反应或分解化学计量地形成底物的参与系统的化合物的测定。 当系统是酶反应时，化合物在一个步骤中测定。 本发明中使用的黄嘌呤氧化酶与已知的黄嘌呤氧化酶的分子量不同，是通过培养属于肠杆菌属的微生物来制备的。

    Antitumor agents
    8.
    发明授权
    Antitumor agents 有权
    抗肿瘤剂

    公开(公告)号：US06716426B1

    公开(公告)日：2004-04-06

    申请号：US09536017

    申请日：2000-03-27

    申请人： Hiroshi Maeda ,  Tomohiro Sawa ,  Takaaki Akaike

    发明人： Hiroshi Maeda ,  Tomohiro Sawa ,  Takaaki Akaike

    IPC分类号： A61K3843

    CPC分类号： C12Y117/03002 ,  A61K31/522 ,  A61K38/44 ,  A61K47/60 ,  C12N11/08 ,  A61K2300/00

    摘要： An antitumor agent, which is a combination of an oxidoreductase, such as xanthine oxidase chemically conjugated to a polymer such as poly ethylene glycol, for initial administration and accumulation in the tumor tissue followed by administration of a substrate for the oxidoreductase which releases reactive oxygen species. Improved tumor selective cytotoxic activity results.

    摘要翻译： 一种抗肿瘤剂，其是氧化还原酶，例如与聚乙二醇等聚合物化学偶联的黄嘌呤氧化酶的组合，用于初始给药并在肿瘤组织中积累，随后施用释放活性氧的氧化还原酶底物 。 改善肿瘤选择性细胞毒活性。

    Lowering Uric Acid to Prevent or Accelerate Recovery of Acute Renal Failure
    10.
    发明申请
    Lowering Uric Acid to Prevent or Accelerate Recovery of Acute Renal Failure 审中-公开
    降低尿酸以预防或加速急性肾衰竭的恢复

    公开(公告)号：US20080317728A1

    公开(公告)日：2008-12-25

    申请号：US11570902

    申请日：2005-06-21

    申请人： Richard J. Johnson

    发明人： Richard J. Johnson

    IPC分类号： A61K38/44 ,  A61P13/12

    CPC分类号： A61K38/50 ,  C12N9/0006 ,  C12Y117/03002

    摘要： Disclosed herein are methods of preventing acute renal failure, ARF, as well as treating and accelerating the recovery of patients experiencing ARF. The inventors believe that an elevated serum uric acid, either occurring at baseline in the patient, or being brought about post-operatively is a major factor leading to ARF. Specifically exemplified are methods that involve administering to a patient at risk of experiencing ARF a composition comprising a uric acid lowering agent.

    摘要翻译： 本文公开了防止急性肾功能衰竭，ARF以及治疗和加速经历ARF的患者的恢复的方法。 本发明人认为，在患者基线时发生或在手术后引起的血清尿酸升高是导致ARF的主要因素。 具体举例说明的方法包括对患有经历ARF的风险的患者施用包含降低尿酸的试剂的组合物。