公开(公告)号：US11911741B2

公开(公告)日：2024-02-27

申请号：US16648521

申请日：2018-10-09

Applicant: Sartorius Stedim Biotech GMBH

Inventor： Karl Pflanz ,  Florian Hebenstreit ,  Andreas Pickl

IPC: B01J20/14 ,  B01J20/30 ,  B01J20/28 ,  B01D37/02 ,  A61L2/08 ,  C12M1/00 ,  B65D65/40 ,  B65B55/02

CPC classification number: B01J20/14 ,  A61L2/081 ,  B01D37/02 ,  B01J20/28004 ,  B01J20/2805 ,  B01J20/28016 ,  B01J20/3028 ,  B65B55/02 ,  B65D65/40 ,  C12M47/02 ,  C12M47/10 ,  A61L2202/21

Abstract: The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.

公开(公告)号：US20200261883A1

公开(公告)日：2020-08-20

申请号：US16648521

申请日：2018-10-09

Applicant: Sartorius Stedim Biotech GMBH

Inventor： Karl Pflanz ,  Florian Hebenstreit ,  Andreas Pickl

IPC: B01J20/14 ,  B01J20/30 ,  B01J20/28 ,  A61L2/08 ,  C12M1/00 ,  B01D37/02 ,  B65D65/40 ,  B65B55/02

Abstract: The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.

公开(公告)号：US20240261754A1

公开(公告)日：2024-08-08

申请号：US18420145

申请日：2024-01-23

Applicant: Sartorius Stedim Biotech GMBH

Inventor： Karl Pflanz ,  Florian Hebenstreit ,  Andreas Pickl

IPC: B01J20/14 ,  A61L2/08 ,  B01D37/02 ,  B01J20/28 ,  B01J20/30 ,  B65B55/02 ,  B65D65/40 ,  C12M1/00

CPC classification number: B01J20/14 ,  A61L2/081 ,  B01D37/02 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/2805 ,  B01J20/3028 ,  B65B55/02 ,  B65D65/40 ,  C12M47/02 ,  C12M47/10 ,  A61L2202/21

Abstract: The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.

公开(公告)号：US11826720B2

公开(公告)日：2023-11-28

申请号：US17775312

申请日：2020-11-06

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Karl Pflanz ,  Andreas Pickl ,  Florian Hebenstreit

IPC: B01J20/02 ,  B01J20/14 ,  B01D37/02 ,  B01J20/04 ,  B01J20/28 ,  B01J20/30 ,  C12M1/00 ,  C12N1/02 ,  C12N5/00

CPC classification number: B01J20/14 ,  B01D37/02 ,  B01J20/046 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/3078 ,  B01J20/3092 ,  C12M47/10 ,  C12N1/02 ,  C12N5/0081

Abstract: The present invention relates to an improved diatomaceous earth composition containing salt water. The diatomaceous earth composition according to the present invention comprises an agglomerated mixture of calcined diatomaceous earth particles, water and at least one inorganic salt, wherein the mass ratio of the calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the content of the at least one inorganic salt is equal to or more than 0.25 parts by mass based on 100 parts by mass of water. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition according to the present invention. In another aspect, the present invention relates to the use of the diatomaceous earth composition according to the present invention as an agent for precoat filtration or dynamic body feed filtration in biopharmaceutical applications.