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    PROTEIN PURIFICATION DEVICE
    1.
    发明申请
    PROTEIN PURIFICATION DEVICE 审中-公开

    公开(公告)号：US20190054397A1

    公开(公告)日：2019-02-21

    申请号：US16102989

    申请日：2018-08-14

    Applicant: Sartorius Stedim Biotech GmbH

    Inventor： Karl Pflanz ,  Andreas Pickl ,  Holger Linne ,  Vanessa Ransiek ,  Kathrin Schroeder-Tittmann

    IPC: B01D15/34 ,  B01D15/12 ,  B01D15/18

    Abstract: A device for purifying protein from a protein-containing fluid includes a prefilter unit, which has at least one size exclusion filter, a membrane adsorber unit, which has at least one porous membrane with functional constituents which adsorb the protein to be purified, and a collecting container. The collecting container, the membrane adsorber unit and the prefilter unit are configured such that the collecting container is suitable for receiving the membrane adsorber unit; and the membrane adsorber unit is suitable for receiving the prefilter unit. An associated method for purifying protein from a protein-containing fluid using the device is also disclosed.

    Liquid filtering system
    5.
    发明授权
    Liquid filtering system 有权

    公开(公告)号：US11666840B2

    公开(公告)日：2023-06-06

    申请号：US17145058

    申请日：2021-01-08

    Applicant: Sartorius Stedim Biotech GmbH

    Inventor： Karl Pflanz ,  Sebastian Pruehl ,  Andreas Pickl ,  Roland Leetsch ,  Adam Gilbert ,  Martin Purshouse

    IPC: B01D35/30 ,  B01D29/085 ,  B01D35/14

    CPC classification number: B01D35/306 ,  B01D29/085 ,  B01D35/14 ,  B01D2201/16 ,  B01D2201/204 ,  B01D2201/305

    Abstract: A filtering system (10) includes a filtering apparatus having a filter unit for receiving liquid to be filtered, a receptacle for receiving filtered liquid, and an adapter (14) for coupling the filter unit to the receptacle, and also includes a base (12) having a cradle (26) for receiving the filtering apparatus and a base vacuum delivery port (28). The adapter includes an adapter vacuum receiving port (22) coupled to the vacuum delivery port for driving the liquid through the filter and—as filtered liquid—into the receptacle. The cradle and the adapter have an interlocking mechanism (52, 54) that locks the filtering apparatus to the cradle in a locking position in which the vacuum receiving port is sealingly coupled to the base vacuum delivery port. The base vacuum delivery port has a vacuum valve (30) constituted as a normally-closed valve automatically forced open when the filtering apparatus locks to the cradle.

    DIATOMACEOUS EARTH COMPOSITION WITH A LOW ENDOTOXIN CONTENT
    6.
    发明申请
    DIATOMACEOUS EARTH COMPOSITION WITH A LOW ENDOTOXIN CONTENT 审中-公开

    公开(公告)号：US20200261883A1

    公开(公告)日：2020-08-20

    申请号：US16648521

    申请日：2018-10-09

    Applicant: Sartorius Stedim Biotech GMBH

    Inventor： Karl Pflanz ,  Florian Hebenstreit ,  Andreas Pickl

    IPC: B01J20/14 ,  B01J20/30 ,  B01J20/28 ,  A61L2/08 ,  C12M1/00 ,  B01D37/02 ,  B65D65/40 ,  B65B55/02

    Abstract: The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.

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