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公开(公告)号：US20130122067A1
公开(公告)日：2013-05-16
申请号：US13812497
申请日：2011-08-04
IPC分类号： A61F2/28
CPC分类号： A61L27/12 , A61F2/28 , A61L27/222 , A61L27/24 , A61L27/32 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/10 , A61L2300/412 , A61L2300/604 , A61L2300/63 , A61L2400/18 , A61L2420/00 , A61L2430/02 , C01B25/32
摘要： The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.
摘要翻译： 本发明涉及用于改善骨愈合的生长抑制型羟基磷灰石。 它与迄今为止使用的磷灰石的不同之处在于，它在生理溶液中释放钙离子和磷酸根离子，与传统的羟基磷灰石不同，它不结合。 从而促进骨再生和骨骼生长。 生长抑制羟基磷灰石含有预结构化胶原模板的附聚物，其上具有低于其临界核半径的微晶生长的羟基磷灰石晶体被外延形成。 它通过以下步骤制备：a）在过饱和的含Ca和磷酸根离子的溶液中预结构化胶原模板的成矿，其中预结构的胶原模板能够扩散和/或迁移，使得HAP微晶在胶原模板上上游生长， 与HAP微晶一起生长的胶原模板由于其扩散和/或迁移的能力而聚集，b）分离附聚物。
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2.发明申请公开(公告)号：US20110237552A1
公开(公告)日：2011-09-29
申请号：US13063469
申请日：2009-09-11
申请人： Sascha Heinemann , Hartmut Worch , Thomas Hanke
发明人： Sascha Heinemann , Hartmut Worch , Thomas Hanke
IPC分类号： A61K47/42 , A61K31/663 , C09D189/00
CPC分类号： A61L27/52 , A61L27/24 , A61L27/34 , A61L27/446 , A61L27/46 , A61L2420/04 , C08L89/06
摘要： The invention relates to novel composite materials based on a collagen matrix mineralised with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an implant material which can be shaped in a plurality of ways, a biological coating or active substance carrier. The claimed composite material comprises a collagen matrix which is mineralised with silicate and a calcium phosphate phase, said collagen being a recombinate collagen, collagen from Eumetazoa, sponge collagen from a sponge of the Demospongia class (horn sponges) or Calcarea (calcareous sponges), a synthetic collage analogue, a collagen derivative or a mixture of said collagens.
摘要翻译： 本发明涉及基于用硅酸盐和磷酸钙相矿化的胶原基质的新型复合材料，其生产方法和其可用作植入材料，其可以以多种方式成型，生物涂层或活性物质 载体 所要求保护的复合材料包括用硅酸盐和磷酸钙相矿化的胶原基质，所述胶原是重组胶原，来自Eumetazoa的胶原，来自Demospongia类海绵的海绵胶原（角海绵）或Calcarea（钙质海绵）， 合成拼贴模拟物，胶原衍生物或所述胶原蛋白的混合物。
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3.发明授权公开(公告)号：US09265861B2
公开(公告)日：2016-02-23
申请号：US13063469
申请日：2009-09-11
申请人： Sascha Heinemann , Hartmut Worch , Thomas Hanke
发明人： Sascha Heinemann , Hartmut Worch , Thomas Hanke
CPC分类号： A61L27/52 , A61L27/24 , A61L27/34 , A61L27/446 , A61L27/46 , A61L2420/04 , C08L89/06
摘要： The invention relates to novel composite materials based on a collagen matrix mineralized with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an implant material which can be shaped in a plurality of ways, a biological coating or active substance carrier. The claimed composite material comprises a collagen matrix which is mineralized with silicate and a calcium phosphate phase, said collagen being a recombinate collagen, collagen from Eumetazoa, sponge collagen from a sponge of the Demospongia class (horn sponges) or Calcarea (calcareous sponges), a synthetic collage analog, a collagen derivative or a mixture of said collagens.
摘要翻译： 本发明涉及基于用硅酸盐和磷酸钙相矿化的胶原基质的新型复合材料，其生产方法和其可用作植入材料，其可以以多种方式成型，生物涂层或活性物质 载体 所要求保护的复合材料包括用硅酸盐和磷酸钙相矿化的胶原基质，所述胶原是重组胶原，来自Eumetazoa的胶原，来自Demospongia类海绵的海绵胶原（角海绵）或Calcarea（钙质海绵）， 合成拼贴模拟物，胶原衍生物或所述胶原蛋白的混合物。
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公开(公告)号：US08916690B2
公开(公告)日：2014-12-23
申请号：US13812497
申请日：2011-08-04
CPC分类号： A61L27/12 , A61F2/28 , A61L27/222 , A61L27/24 , A61L27/32 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/58 , A61L2300/10 , A61L2300/412 , A61L2300/604 , A61L2300/63 , A61L2400/18 , A61L2420/00 , A61L2430/02 , C01B25/32
摘要： The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.
摘要翻译： 本发明涉及用于改善骨愈合的生长抑制型羟基磷灰石。 它与迄今为止使用的磷灰石的不同之处在于，它在生理溶液中释放钙离子和磷酸根离子，与传统的羟基磷灰石不同，它不结合。 从而促进骨再生和骨骼生长。 生长抑制羟基磷灰石含有预结构化胶原模板的附聚物，其上具有低于其临界核半径的微晶生长的羟基磷灰石晶体被外延形成。 它通过以下步骤制备：a）在过饱和的含Ca和磷酸根离子的溶液中预结构化胶原模板的成矿，其中预结构的胶原模板能够扩散和/或迁移，使得HAP微晶在胶原模板上上游生长， 与HAP微晶一起生长的胶原模板由于其扩散和/或迁移的能力而聚集，b）分离附聚物。
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